scholarly journals A summary of further experimental researches on the etiology of endemic goitre. (Second series.)

The object of the research was to test by further experimentation on man the accuracy of the results communicated to the Royal Society on November 26, 1908. These results afforded evidence that goitre was due to a living organism of disease present in the water of goitrous localities, that the causal factor of the disease was destroyed by boiling, and that it inhabited, in all probability, the intestinal tract of man. I. Twenty-three individuals, of the average age of 22, consumed the suspended matter of goitre-producing water for periods of from 30 to 55 days. Of these, six showed an increase in size of the thyroid gland which persisted in a more or less well-marked manner up to the end of the experiments. Three others showed a thyroid hypertrophy of a transitory character.

The object of the research was to determine by experiment on man whether goitre was caused by matter held in suspension in goitre-producing waters; and to ascertain, as far as possible, the nature of the suspended ingredient which had been surmised to be responsible for the production of the disease. Thirteen individuals, including myself, were given suspended matter, which had been removed by filtration from goitre-producing water, every morning before the first meal of the day. I and three others developed enlargements of the thyroid gland. The experiment was repeated in the case of eight individuals who were given the same suspended matter, which had previously been boiled for 10 minutes; in no case did any enlargement of the thyroid gland occur.


1964 ◽  
Vol 45 (3) ◽  
pp. 381-401 ◽  
Author(s):  
G. Hintze ◽  
P. Fortelius ◽  
J. Railo

ABSTRACT A type of subacute thyroiditis occurring epidemically in a factory in Helsinki was observed in 44 cases. In every case the thyroiditis followed an acute infection of the upper respiratory tract. The variation in incidence during one and a half years was in good agreement with that of the acute infection. Since Helsinki is in an endemic goitre region, the fact that the disease was of the migrating type was of great diagnostic importance. In all cases but one, the nodules have persisted. One case of asymptomatic thyroiditis was seen. In the majority of the patients the thyroid gland had been carefully palpated before the thyroiditis occurred, and in all cases the condition was followed up by the same investigator. Special attention was paid to changes in the iodine metabolism, the serum cholesterol, the electrophoretic distribution pattern of the serum proteins, and the circulating thyroid auto-antibodies. In many cases needle biopsy of the thyroid gland was performed. Thyroid function invariably returned to normal with time, although one patient remained in a hypothyroid state for about a year. In no cases were thyroid auto-antibodies found. For the beta-globulin fraction, the electrophoretic distribution pattern of the serum proteins gave values which were still not normalized in any case, and only in two cases was the alpha2-fraction normalized. The needle biopsy, when thyroid tissue was obtained, showed almost the same picture as in endemic goitre, but in some specimens nonspecific inflammatory changes were seen. Prednisolone relieved the symptoms, but did not affect the course of the disease. According to the present observation this type of epidemic thyroiditis would seem to represent a form of nonspecific subacute thyroiditis.


Author(s):  
Wilmar M. Wiersinga

Goitres can be classified according to thyroid function into toxic goitres, hypothyroid goitres, and euthyroid or nontoxic goitres (see Chapter 3.5.1). The most prevalent causes of nontoxic goitre are endemic (iodine-deficient) goitre and sporadic nontoxic goitre (diffuse or nodular). The disease entity of sporadic nontoxic goitre is defined as a benign enlargement of the thyroid gland of unknown cause, in euthyroid patients (normal serum free thyroxine (T4) and free triiodothyronine (T3) concentrations) living in an area without endemic goitre. The diagnosis is by exclusion. The prevalence of sporadic nontoxic goitre (also called simple goitre) in the adult population is high, 3.2% in the UK (see Chapter 3.1.7), and it is more common in women (5.3%) than in men (0.8%). This chapter deals predominantly with sporadic nontoxic multinodular goitre.


1883 ◽  
Vol 35 (224-226) ◽  
pp. 19-20

In the year 1879 I communicated to the Royal Society a paper “On an Induction Currents Balance and Experimental Researches made therewith.” I continued my researches into the molecular construction of metallic bodies, and communicated the results then obtained in three separate papers bearing upon molecular magnetism. To investigate the molecular construction of magnets required again special forms of apparatus, and I have since been engaged upon these, and the researches which they have enabled me to follow.


Author(s):  
Makoto Kato ◽  
Gyo Itani

Ecological, behavioural and anatomical observations of a commensal bivalve, Peregrinamor ohshimai (Mollusca: Galeommatoidea), were carried out in a tidal mudflat in the Seto Inland Sea, Japan. The bivalve attached specifically to the longitudinal groove of the ventral side of the cephalothorax of thalassinidean burrowing shrimps, Upogebia major and Lf. narutensis (Crustacea: Decapoda), singly, dorso-ventrally and longitudinally, using its byssus, with its anterior part towards the head of the host. The mantle of the commensal bivalve has wide anterior (branchio-pedal) and narrow posterior (exhalant) apertures. In the living organism, the extended anterior edges of the mantle protrude from the shell and are inserted into the host's filtering basket, which is formed by the setal rows of the first two pairs of pereiopods and utilized for intercepting suspended matter. By beating its pleopods in a U-shaped burrow, the filter-feeding Upogebia shrimp creates water currents, which are also utilized by the commensal bivalve for filter-feeding. The shell length of the commensal bivalve was in proportion to the host's carapace length. This suggests that the veliger larva attaches to a young host and grows, thus maintaining the host-commensal morphological matching. The bivalve is a hermaphrodite and individuals of >8–5 mm in shell length were already producing eggs. Anatomical observations suggest that P. ohshimai is most closely related to the Montacutidae in Galeommatoidea.


1850 ◽  
Vol 140 ◽  
pp. 171-188 ◽  

Four years ago I suggested that all the phenomena presented by diamagnetic bodies, when subjected to the forces in the magnetic field, might be accounted for by assuming that they then possessed a polarity the same in kind as, but the reverse in direction of, that acquired by iron, nickel and ordinary magnetic bodies under the same circumstances (2429. 2430.). This view was received so favourably by Plücker, Reich and others, and above all by W. Weber, that I had great hopes it would be confirmed; and though certain experiments of my own (2497.) did not increase that hope, still my desire and expectation were in that direction. Whether bismuth, copper, phosphorus, &c., when in the magnetic field, are polar or not, is however an exceedingly important question; and very essential and great differences, in the mode of action of these bodies under the one view or the other, must be conceived to exist. I found that in every endeavour to proceed by induction of experiment from that which is known in this department of science to the unknown, so much uncertainty, hesitation and discomfort arose from the unsettled state of my mind on this point, that I determined, if possible, to arrive at some experimental proof either one way or the other. This was the more needful, because of the conclusion in the affirmative to which Weber had come in his very philosophical paper; and so important do I think it for the progress of science, that, in those imperfectly developed regions of knowledge, which form its boundaries, our conclusions and deductions should not go far beyond, or at all events not aside from the results of experiment (except as suppositions), that I do not hesitate to lay my present labours, though they arrive at a negative result, before the Royal Society.


1834 ◽  
Vol 12 (2) ◽  
pp. 429-461 ◽  
Author(s):  
James D. Forbes

1. On the 17th January 1831, Mr Arthur Trevelyan communicated to the Royal Society of Edinburgh a paper, entitled “Notice regarding some phenomena observed during the Cooling of certain Metals placed in contact with Lead.” This was the first account published of the remarkable discovery made by that gentleman, of a most curious class of phenomena, which till then was unknown to the scientific world. This paper was afterwards published, with some additions, in the 12th volume of the Transactions of that body, under the title of “Notice regarding some Observations on the Vibrations of Heated Metals.”2. Mr Trevelyan had, in February 1829, first observed the phenomena just alluded to, which consist in certain tremulous motions accompanied by sounds, often highly musical, excited in many metals while hot, placed in contact with lead or tin, at a lower temperature.


1843 ◽  
Vol 133 ◽  
pp. 17-32 ◽  

2075. Two years ago an experiment was described by Mr. Armstrong and others, in which the issue of a stream of high pressure steam into the air produced abundance of electricity. The source of the electricity was not ascertained, but was supposed to be the evaporation or change of state of the water, and to have a direct relation to atmospheric electricity. I have at various times since May of last year been working upon the subject, and though I perceive Mr. Armstrong has, in recent communi­cations, anticipated by publication some of the facts which I also have obtained, the Royal Society may still perhaps think a compressed account of my results and con­clusions, which include many other important points, worthy its attention. 2076. The apparatus I· have used was not competent to furnish me with much steam or a high pressure, but I found it sufficient for my purpose, which was the in­vestigation of the effect and its cause, and not necessarily an increase of the electric development. Mr. Armstrong, as is shown by a recent paper, has well effected the latter. The boiler I used, belonging to the London Institution, would hold about ten gallons of water, and allow the evaporation of five gallons. A pipe 4½ feet long was attached to it, at the end of which was a large stop-cock and a metal globe, of the capacity of thirty-two cubic inches, which I will call the steam-globe , and to this globe, by its mouth-piece, could be attached various forms of apparatus, serving as vents for the issuing steam. Thus a cock could be connected with the steam-globe, and this cock be used as the experimental steam-passage; or a wooden tube could be screwed in; or a small metal or glass tube put through a good cork, and the cork screwed in; and in these cases the steam way of the globe and tube leading to the boiler was so large, that they might be considered as part of the boiler, and these terminal passages as the obstacles which, restraining the issue of steam, produced any important degree of friction.


1832 ◽  
Vol 122 ◽  
pp. 279-298 ◽  

The splendid discoveries which have lately been made in magnetism and electro-magnetism have so much engaged the attention of philosophers, that the theory and laws of action of voltaic electricity, no longer possessing the charms of novelty, have been entirely neglected. The subject appearing to me full of interest, and lying at the very foundation of a large portion of physical science, induced me to undertake an experimental investigation of some of the most important points connected with it, the result of which I have the honour of laying before the Royal Society.


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