Address of the President Professor A. L. Hodgkin at the Anniversary Meeting, 30 November 1971
Award of Medals 1971 The Copley Medal is awarded to Mr N. W. Pirie, F.R.S. for his outstanding work on the nature of viruses. Pirie discovered the chemical composition of viruses and his work transformed ideas about their morphology and method of multiplication. He was the first to show that nucleic acid is a necessary component of a virus and, at a time when tobacco mosaic virus was thought to be a crystalline globulin, he made liquid crystalline preparations of several strains which he correctly identified as nucleoproteins containing 5 % ribose nucleic acid. He then generalized his discovery by isolating several other viruses, with widely different stabilities and other properties, in crystalline or liquid crystalline forms, and by showing th at all contained nucleic acid, but in amounts and held in ways that differed characteristically in different viruses. His work was the first to show that different viruses differed greatly in shape and that those with anisometric particles could change their length in vitro . X-ray crystallography applied to his preparations provided the first accurate information about the sizes of virus particles and first showed them to be composed of uniform subunits regularly arranged. Pirie also showed that nucleic acids could be much larger than generally thought, and the methods he used to prepare them were among those used by later workers who showed that nucleic acid alone could be infective.