Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid Cancers

In a phase 1 trial involving patients with refractory lymphoid cancer, an antibody-drug complex directed against ROR1 had no unexpected toxicities. About half of the patients with mantle cell lymphoma and diffuse large B-cell lymphoma had clinically meaningful responses.

Synthesis and Antibacterial Property of An Encapsulated Sulfonamide Nanoparticle in a Multidisciplinary Approach

Multigram quantity of a novel Sulfa Drug complex -poly(amido)amine-sulfonamide or PAMAM-Sulfa- was synthesized, from commercially available materials. It was characterized with spectroscopic methods such as nuclear magnetic resonance (NMR). The Kirby-Bauer test was used to test it against gram positive and/or gram negative bacteria using different concentrations of an ethanol solution of the PAMAM-Sulfa complex. The goal of this experiment was to synthesize and study the effect of water soluble encapsulated sulfonamides on common bacteria by undergraduate students engaging in research involving more than one STEM discipline. Students synthesized a dendrimer-sulfonamide complex before evaluating its antibiotic properties. In doing so, students employed research methods that are common to chemistry, biology and nanoscience while also learning about mechanism of infectious diseases, drugs and drug resistance. This project allowed students to combine aspects of scientific research that are usually done separately, and an opportunity to observe the seamlessness of multidisciplinary science.

Adsorption Behavior of an Adamantane Derivative on Metal Clusters – DFT Simulation Studies

Investigation of the adsorption properties of 3-(adamantan-1-yl)-4-phenyl-1-[(4-phenylpiperazin-yl)methyl]-1H-1,2,4-triazole-5(4H)-thione (APT) with metal clusters (mC: Ag, Au and Cu) are reported using DFT method. APT is found to form stable cluster with transition metal clusters of copper, silver and gold. The drug-cluster complexation energy is slightly more for the gold nanocluster-drug complex. Dipole moment of the drug-gold cluster is found to be higher than that of the other systems. SERS studies demonstrate improved Raman signals for multiple wavenumbers of all APT-metal cluster complexes. Different spectroscopic, chemical and electronic properties are also investigated.

Computational investigation of interaction between titanocene dichloride and nanoclusters (B12N12, B12P12, Al12N12 and Al12P12)

This study investigated the interactions between B12N12, B12P12, Al12N12 and Al12P12 nanoclusters and titanocene dichloride anticancer drug complex using B3P86 functional. The bonding interaction between the nano-clusters and anticancer drug were examined through energy decomposition analysis (EDA). A good quadratic equation between interaction energy and molar volume (Vm) were provided. Charge transfer between fragments were illustrated with electrophilicity-based charge transfer (ECT). According to calculations, the values of heat of formation of the studied systems were negative (exothermic), which shows that these molecules are thermodynamically stable. The relationship between molar refractivity (MR) and Vm presented linear correlation.

Description of medication adherence in hypertensive respondents at Mandalika Mataram elderly social centre

Introduction: Elderly people are at high risk of non-adherence to hypertensive therapy due to changes in body function and ageing processes. Objectives: The purpose of this study is to explore medication adherence among hypertensive respondents at the Mandalika Mataram NTB Elderly Social Centre. Methods: This study is descriptive observational with a purposive sampling technic. The sample consisted of 30 respondents who met the inclusion criteria. Data were collected using the Modified Morisky Adherence Scale (MMAS-8). Results: The results showed that adherence among participants was high (23.3%), moderate (56.1%), and low (20.0%). Respondent adherence was associated with the role of health workers in monitoring drug therapy. Non-adherence was several factors, including side effects of the drug, complex drug regimens, and ageing.

Morphological and functional criteria for the effectiveness of recreational activities in children

Objective. The study aimed to perform a comprehensive morphofunctional assessment of the effectiveness of recreational activities in children aged 9–12 years in the summer of 2019.Materials and methods. The study was conducted by the “Problem scientific laboratory of physical methods of diagnosis and treatment” of RostGMU in the children’s health and recreation camp “Mir” (Krasnyi Desant village, Gulf of Taganrog). Procedures and time of the study: somatometry, bioimpedance analysis, сardiointervalography, stabilometrics on the 2nd day of stay and 2.5 weeks after. Two groups were formed: Group I included overweight children (OW), n = 15 (boys, n = 9; girls, n = 6); Group II included children with normal physical development (NPD), n = 37 (boys, n = 17; girls, n = 20). The children received a non-drug complex of camp resource provision for 3 weeks.Results. Health measures did not lead to significant changes in the somatometric parameters. According to the results of the сardiointerval recording, an authentic increase in the variational range and vegetative rhythm index was found in children with NPD, which indicates an increase in the parasympathetic activity of regulation. The stress index decreased by 30% in the case of NPD, and by 6% in the case of OW. Data from the stabilometric “Balls” simulator showed that after the recovery, the regulation of postural control was optimized, and decision-making processes were accelerated, especially in children with NPD.Conclusion. The study showed that in order to assess the effectiveness of recreational activities, along with “mandatory” methods, it is advisable to use functional methods such as cardiointervalography and stabilometrics, which can be recommended for use in health and rehabilitation institutions to assess the adaptive capabilities of the organism.

The cocaine-e-cigarette – A theoretical concept of a harm reduction device for current users of smokable cocaine forms

Although there are great regional differences, smokable forms of cocaine (crack, free-base, paco, etc.) are a drug complex associated with often harmful and problematic drug use patterns. While strategies based on drug prohibition did not eradicate the consumption of smokable cocaine forms, prohibition itself led to many harmful effects, such as criminalisation, stigmatisation, unpredictable smokable cocaine forms quality and hardly any safer-use education. While there are many positive insights from heroin-assisted treatment programs with regard to heroin users, there are no comparable programs for problematic users of smokable cocaine forms. Smokable cocaine forms are challenging due to their different pharmacology and particularly their short duration leading to often many administrations per day. In this manuscript a device for a heroin-assisted treatment-like program for problematic users of smokable cocaine forms is suggested. This device is a cocaine-e-cigarette which could be prescribed to problematic users of smokable cocaine forms to reduce the risk of lung damage, exclude potentially harmful adulterants, limit intake (by formulation and/or technical settings) and also to bring users of smokable cocaine forms into the medical system to address comorbidities and risk factors, for example cardiovascular conditions, insomnia, depression, etc. This manuscript describes basic functionality and general specifications of a cocaine-e-cigarette as a medical device treating people with respective cocaine use disorder when cessation and substitution are not considered an option.

Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery

Background: The development of modern nanomedicine greatly depends on the involvement of novel materials as drug delivery system. In order to maximize the therapeutic effects of drugs and minimize their side effects, a number of natural or synthetic materials have been widely investigated for drug delivery. Among these materials, biomimetic self-assembling peptides (SAPs) have received more attention in recent years. Considering the rapidly growing number of SAPs designed for drug delivery, a summary of how SAPs-based drug delivery systems were designed, would be beneficial. Method: We outlined research works on different SAPs that have been investigated as carriers for different drugs, focusing on the design of SAPs nanomaterials and how they were used for drug delivery in different strategies. Results: Based on the principle rules of chemical complementarity and structural compatibility, SAPs such as ionic self-complementary peptide, peptide amphiphile and surfactant-like peptide could be designed. Determined by the features of peptide materials and the drugs to be delivered, different strategies such as hydrogel embedding, hydrophobic interaction, electrostatic interaction, covalent conjugation or the combination of them could be employed to fabricate SAPs-drug complex, which could achieve slow release, targeted or environment-responsive delivery of drugs. Furthermore, some SAPs could also be combined with other types of materials for drug delivery, or even act as drug by themselves. Conclusion: Various types of SAPs have been designed and used for drug delivery following various strategies, suggesting that SAPs as a category of versatile nanomaterials have promising potential in the field of nanomedicine.