scholarly journals GB virus B infection of the common marmoset (Callithrix jacchus) and associated liver pathology

2004 ◽  
Vol 85 (9) ◽  
pp. 2525-2533 ◽  
Author(s):  
James R. Jacob ◽  
Kuei-Chin Lin ◽  
Bud C. Tennant ◽  
Keith G. Mansfield
Keyword(s):  
Acute Hepatitis ◽  
New World ◽  
Antiviral Drug ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Primate Species ◽  
New World Primates ◽  
Common Marmosets ◽  
The Common ◽  
Human Primate

GB virus B (GBV-B) is a flavivirus that is related closely to hepatitis C virus (HCV) and induces an acute hepatitis when inoculated into several species of New World primates. Common marmosets (Callithrix jacchus) are a widely available, non-endangered primate species that is susceptible to GBV-B infection and develops a characteristic acute hepatitis. Here, animals were found to be susceptible to serially passaged serum and GBV-B transcripts. Hepatic pathology and peripheral viraemia could be quantified biochemically, immunophenotypically and morphologically, and persisted for periods of up to 6 months in some animals. Hepatitis was characterized by a marked influx of CD3+ CD8+ T lymphocytes and CD20+ B cells within the first 2 months of primary infection. The results of this study document the marmoset as another small, non-human primate species in which the pathogenesis of GBV-B can be studied and used as a surrogate model of HCV infection for investigation of pathogenesis and antiviral drug development.

scholarly journals Expression of taste signal transduction molecules in the caecum of common marmosets

2013 ◽  
Vol 9 (4) ◽  
pp. 20130409 ◽  
Author(s):  
Sae Gonda ◽  
Shuichi Matsumura ◽  
Shoichiro Saito ◽  
Yasuhiro Go ◽  
Hiroo Imai
Keyword(s):  
Signal Transduction ◽  
Immunohistochemical Analysis ◽  
Common Marmoset ◽  
Rt Pcr ◽  
Common Marmosets ◽  
Plant Exudates ◽  
The Common ◽  
Signal Transduction Proteins ◽  
First Time ◽  
Human Primate

The extraoral presence of taste signal transduction proteins has recently been reported in rodents and humans. Here, we report for the first time the presence of these signal transduction proteins in the caecum of a non-human primate, the common marmoset. Quantitative RT-PCR data on the gene expression of taste signal transduction molecules (gustducin and TRPM5) in common marmosets suggested high expression in the caecum, which was not observed in other non-human primates. Immunohistochemical analysis confirmed the specific presence of gustducin and taste receptors in marmoset caecal cells. These results may relate to the specific feeding behaviour of marmosets, which consume plant exudates, primarily gums.

scholarly journals A Novel Marmoset (Callithrix jacchus) Model of Human Inhalational Q Fever

2021 ◽  
Vol 10 ◽  
Author(s):  
Michelle Nelson ◽  
Francisco J. Salguero ◽  
Laura Hunter ◽  
Timothy P. Atkins
Keyword(s):  
Q Fever ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Suitable Model ◽  
Dependent Manner ◽  
Cellular Activation ◽  
Common Marmosets ◽  
Counter Measures ◽  
The Common ◽  
Dose Dependent

Common marmosets (Callithrix jacchus) were shown to be susceptible to inhalational infection with Coxiella burnetii, in a dose-dependent manner, producing a disease similar to human Q fever, characterized by a resolving febrile response. Illness was also associated with weight loss, liver enzyme dysfunction, characteristic cellular activation, circulating INF-γ and bacteraemia. Viable C. burnetii was recovered from various tissues during disease and from 75% of the animal’s lungs on 28 days post challenge, when there were no overt clinical features of disease but there was histological evidence of macrophage and lymphocyte infiltration into the lung resulting in granulomatous alveolitis. Taken together, these features of disease progression, physiology and bacterial spread appear to be consistent with human disease and therefore the common marmoset can be considered as a suitable model for studies on the pathogenesis or the development of medical counter measures of inhalational Q fever.

Discrete retinal input to the parabrachial complex of a new-world primate, the common marmoset (Callithrix jacchus)

2008 ◽  
Vol 443 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Rovena Clara Galvão Januário Engelberth ◽  
André Luíz Bezerra de Pontes ◽  
Rayane Bartira Silva do Nascimento ◽  
Ruthnaldo Rodrigues Melo de Lima ◽  
Raissa Rodrigues de Lima ◽  
...  
Keyword(s):  
New World ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
World Primate ◽  
Retinal Input ◽  
The Common

scholarly journals The common marmoset: A new world primate species with limited Mhc class II variability

1998 ◽  
Vol 95 (20) ◽  
pp. 11745-11750 ◽  
Author(s):  
S. G. Antunes ◽  
N. G. de Groot ◽  
H. Brok ◽  
G. Doxiadis ◽  
A. A. L. Menezes ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
New World ◽  
Common Marmoset ◽  
Class Ii ◽  
Primate Species ◽  
World Primate ◽  
The Common

scholarly journals DNA methylation age analysis of rapamycin in common marmosets

2020 ◽  
Author(s):  
Steve Horvath ◽  
Joseph A. Zoller ◽  
Amin Haghani ◽  
Ake T. Lu ◽  
Ken Raj ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Rhesus Macaques ◽  
Common Marmoset ◽  
Primate Species ◽  
Vervet Monkeys ◽  
Methylation Data ◽  
Common Marmosets ◽  
Biomarkers Of Aging ◽  
Epigenetic Age ◽  
The Common

AbstractHuman DNA methylation data have previously been used to develop highly accurate biomarkers of aging (“epigenetic clocks”). Subsequent studies demonstrate that similar epigenetic clocks can also be developed for mice and many other mammals. Here, we describe epigenetic clocks for common marmosets (Callithrix jacchus) based on novel DNA methylation data generated from highly conserved mammalian CpGs that were profiled using a custom Infinium array (HorvathMammalMethylChip40). From these, we developed and present here, two epigenetic clocks for marmosets that are applicable to whole blood samples. We find that the human-marmoset clock for relative age exhibits moderately high age correlations in two other non-human primate species: vervet monkeys and rhesus macaques. In a separate cohort of marmosets, we tested whether intervention with rapamycin, a drug shown to extend lifespan in mice, would alter the epigenetic age of marmosets, as measured by the marmoset epigenetic clocks. These clocks did not detect significant effects of rapamycin on the epigenetic age of marmoset blood. The common marmoset stands out from other mammals in that it is not possible to build accurate estimators of sex based on DNA methylation data: the accuracy of a random forest predictor of sex (66%) was substantially lower than that observed for other mammals (which is close to 100%). Overall, the epigenetic clocks developed here for the common marmoset are expected to be useful for age estimation of wild-born animals and for anti-aging studies in this species.

scholarly journals The effects of cage size and complexity on the behaviour of captive common marmosets, Callithrix jacchus jacchus

1996 ◽  
Vol 30 (4) ◽  
pp. 317-326 ◽  
Author(s):  
Ann M. Kitchen ◽  
Angus A. Martin
Keyword(s):  
Common Marmoset ◽  
Callithrix Jacchus ◽  
General Level ◽  
Housing Conditions ◽  
Common Marmosets ◽  
Level Of Activity ◽  
Cage Size ◽  
The Common ◽  
Stereotyped Behaviours ◽  
Callithrix Jacchus Jacchus

Conditions of captivity of primates used in biomedical research may have deleterious effects on the welfare of the animals and consequently on the reliability of the research. We investigated the effects of cage size and cage complexity, two fundamental characteristics of captive conditions, on the behaviour of the common marmoset ( Callithrix jacchus jacchus). We found an increase in the general level of activity and significant variation in the frequencies of specific behaviours with an increase in cage size and also with cage complexity. Stereotyped behaviours, which occurred in the small cages, were never exhibited in the large cages. The effect of the novelty of the changed conditions was also assessed and found to be significant for some behaviours. We also measured the time taken to capture an animal, a task frequently performed by the animal technician, under the various cage conditions. Capture time increased significantly in the larger cages, but the overall effect of the changes to the marmosets' housing conditions on the animal technician's work was not regarded as substantial. We conclude that the welfare of captive marmosets is enhanced by the provision of larger and more complex cages, and that such cages do not significantly affect the efficiency of the research laboratory.

The common marmoset (Callithrix jacchus) consultation

2019 ◽  
Vol 24 (6) ◽  
pp. 329-337
Author(s):  
Sarah Pellett ◽  
Livia Benato
Keyword(s):  
General Practice ◽  
Common Marmoset ◽  
Psychological Needs ◽  
Callithrix Jacchus ◽  
Common Marmosets ◽  
Social Species ◽  
Basic Care ◽  
The Common

Common marmosets (Callithrix jacchus) can sometimes be seen in general practice and it is essential to be aware of their nutritional, environmental and medical requirements. The keeping of common marmosets as pets is not recommended; they can be aggressive and unpredictable, and many are subjected to suboptimal husbandry. They are social species with psychological needs and good welfare is often difficult to achieve. This article summarises the basic care of common marmosets, discusses the approach to veterinary care, and highlights some important diseases that the clinician may see.

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