scholarly journals Coupling of tactile LFP signals between mouse cortex and olfactory bulb

2017 ◽  
Author(s):  
Ana Parabucki ◽  
Ilan Lampl
Keyword(s):  
Olfactory Bulb ◽  
Local Field ◽  
Orbitofrontal Cortex ◽  
Barrel Cortex ◽  
Brain Activity ◽  
Field Potential ◽  
Field Potentials ◽  
Mouse Cortex ◽  
Highly Correlated ◽  
Potential Signal

SummaryLocal field potentials are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker evoked local field potential signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conductance signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few millimeters away. Thus, we suggest that special care should be taken when acquiring and interpreting LFP data.

scholarly journals Novel Porous Brain Electrodes for Augmented Local Field Potential Signal Detection

Materials ◽  
2019 ◽  
Vol 12 (3) ◽  
pp. 542 ◽  
Author(s):  
Sung Lee ◽  
Kyeong-Seok Lee ◽  
Saurav Sorcar ◽  
Abdul Razzaq ◽  
Maan-Gee Lee ◽  
...  
Keyword(s):  
Local Field ◽  
Local Field Potential ◽  
Brain Activity ◽  
Field Potential ◽  
Porous Electrodes ◽  
Surface Topology ◽  
Neural Electrode ◽  
Flow Of Information ◽  
Potential Signal ◽  
Local Field Potential Lfp

Intracerebral local field potential (LFP) measurements are commonly used to monitor brain activity, providing insight into the flow of information across neural networks. Herein we describe synthesis and application of a neural electrode possessing a nano/micro-scale porous surface topology for improved LFP measurement. Compared with conventional brain electrodes, the porous electrodes demonstrate higher measured amplitudes with lower noise levels.

scholarly journals Chronic, Multi-Site Recordings Supported by Two Low-Cost, Stationary Probe Designs Optimized to Capture Either Single Unit or Local Field Potential Activity in Behaving Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Miranda J. Francoeur ◽  
Tianzhi Tang ◽  
Leila Fakhraei ◽  
Xuanyu Wu ◽  
Sidharth Hulyalkar ◽  
...  
Keyword(s):  
Local Field ◽  
Single Unit ◽  
Large Scale ◽  
Brain Activity ◽  
Low Cost ◽  
Local Field Potentials ◽  
Field Potential ◽  
Brain Regions ◽  
Field Potentials ◽  
Brain Target

Rodent models of cognitive behavior have greatly contributed to our understanding of human neuropsychiatric disorders. However, to elucidate the neurobiological underpinnings of such disorders or impairments, animal models are more useful when paired with methods for measuring brain function in awake, behaving animals. Standard tools used for systems-neuroscience level investigations are not optimized for large-scale and high-throughput behavioral battery testing due to various factors including cost, time, poor longevity, and selective targeting limited to measuring only a few brain regions at a time. Here we describe two different “user-friendly” methods for building extracellular electrophysiological probes that can be used to measure either single units or local field potentials in rats performing cognitive tasks. Both probe designs leverage several readily available, yet affordable, commercial products to facilitate ease of production and offer maximum flexibility in terms of brain-target locations that can be scalable (32–64 channels) based on experimental needs. Our approach allows neural activity to be recorded simultaneously with behavior and compared between micro (single unit) and more macro (local field potentials) levels of brain activity in order to gain a better understanding of how local brain regions and their connected networks support cognitive functions in rats. We believe our novel probe designs make collecting electrophysiology data easier and will begin to fill the gap in knowledge between basic and clinical research.

scholarly journals Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jakob Jessberger ◽  
Weiwei Zhong ◽  
Jurij Brankačk ◽  
Andreas Draguhn
Keyword(s):  
Olfactory Bulb ◽  
Local Field ◽  
Respiratory Rhythm ◽  
Local Field Potentials ◽  
Nrem Sleep ◽  
Network Activity ◽  
Whole Body ◽  
Field Potentials ◽  
Biophysical Parameters ◽  
Similar Frequency

It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. It is therefore important to measure RR and to delineate it from endogenous electrical rhythms like theta which cover similar frequency bands in small rodents. In order to validate such measurements in freely behaving mice, we compared rhythmic LFP in the OB with two respiration-related biophysical parameters: whole-body plethysmography (PG) and nasal temperature (thermocouple; TC). During waking, all three signals reflected respiration with similar reliability. Peak power of RR in OB decreased with increasing respiration rate whereas power of PG increased. During NREM sleep, respiration-related TC signals disappeared and large amplitude slow waves frequently concealed RR in OB. In this situation, PG provided a reliable signal while breathing-related rhythms in TC and OB returned only during microarousals. In summary, local field potentials in the olfactory bulb do reliably reflect respiratory rhythm during wakefulness and REM sleep but not during NREM sleep.

Odor vapor pressure and quality modulate local field potential oscillatory patterns in the olfactory bulb of the anesthetized rat

2008 ◽  
Vol 27 (6) ◽  
pp. 1432-1440 ◽  
Author(s):  
Tristan Cenier ◽  
Corine Amat ◽  
Philippe Litaudon ◽  
Samuel Garcia ◽  
Pierre Lafaye de Micheaux ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Vapor Pressure ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential

Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb

2014 ◽  
Vol 580 ◽  
pp. 1-6 ◽  
Author(s):  
Ling Gong ◽  
Bo Li ◽  
Ruiqi Wu ◽  
Anan Li ◽  
Fuqiang Xu
Keyword(s):  
Olfactory Bulb ◽  
Local Field ◽  
Local Field Potentials ◽  
Brain State ◽  
Field Potentials ◽  
State Dependent

Reconstruction of intracortical whisker-evoked local field potential from electrocorticogram using a model trained for spontaneous activity in the rat barrel cortex

2014 ◽  
Vol 87 ◽  
pp. 40-48 ◽  
Author(s):  
Hidenori Watanabe ◽  
Tomoya Sakatani ◽  
Takafumi Suzuki ◽  
Masa-aki Sato ◽  
Yukio Nishimura ◽  
...  
Keyword(s):  
Spontaneous Activity ◽  
Local Field ◽  
Local Field Potential ◽  
Barrel Cortex ◽  
Field Potential

Imaging local field potentials in the rat barrel cortex

2015 ◽  
Author(s):  
Claudia Cecchetto ◽  
Sven Schroder ◽  
Stefan Keil ◽  
Mufti Mahmud ◽  
Evelin Brose ◽  
...  
Keyword(s):  
Local Field ◽  
Barrel Cortex ◽  
Local Field Potentials ◽  
Field Potentials

scholarly journals Sensing Local Field Potentials with a Directional and Scalable Depth Array: DISC

2021 ◽  
Author(s):  
Amada Abrego Mancilla ◽  
Wasif Khan ◽  
Christopher E Wright ◽  
Neela Prajapati ◽  
M Rabiul Islam ◽  
...  
Keyword(s):  
Local Field ◽  
Barrel Cortex ◽  
Current Source ◽  
Local Field Potentials ◽  
Brain Targeting ◽  
Directional Sensitivity ◽  
Cortical Region ◽  
Field Potentials ◽  
Electromagnetic Modeling ◽  
Functional Therapy

A variety of electrophysiology tools are available to the neurosurgeon for diagnosis, functional therapy, and neural prosthetics. However, no tool can currently address these three critical recording needs: (i) a surgical method that can reach any cortical region in a minimally invasive manner; (ii) record microscale, mesoscale, and macroscale resolutions simultaneously; and (iii) enable recording from multiple brain regions. This work presents a novel device for recording local field potentials (LFPs) whose form is based on state-of-the-art stereo-electroencephalogram (sEEG). Using quasi-static electromagnetic modeling, the lead body is shown to shield LFP sources and this enables directional sensitivity and scalability when microelectrodes are positioned radially, which we refer to as a DISC array. As predicted, DISC demonstrated significantly improved signal-to-noise, directional sensitivity, and decoding accuracy in the rat barrel cortex during whisker stimulation. Critically, DISC also demonstrated equivalent fidelity at the macroscale and, uniquely, performs current source density in stereo. Directional sensitivity of LFPs may significantly improve brain-computer interfaces and many diagnostic procedures, including epilepsy foci detection and deep brain targeting.

scholarly journals Simultaneous Two-Photon Voltage or Calcium Imaging and Multi-Channel Local Field Potential Recordings in Barrel Cortex of Awake and Anesthetized Mice

2021 ◽  
Vol 15 ◽  
Author(s):  
Claudia Cecchetto ◽  
Stefano Vassanelli ◽  
Bernd Kuhn
Keyword(s):  
Local Field ◽  
Calcium Imaging ◽  
Local Field Potential ◽  
Barrel Cortex ◽  
Field Potential ◽  
Imaging Data ◽  
Spatiotemporal Resolution ◽  
Two Photon ◽  
Cranial Window ◽  
Sensory Evoked

Neuronal population activity, both spontaneous and sensory-evoked, generates propagating waves in cortex. However, high spatiotemporal-resolution mapping of these waves is difficult as calcium imaging, the work horse of current imaging, does not reveal subthreshold activity. Here, we present a platform combining voltage or calcium two-photon imaging with multi-channel local field potential (LFP) recordings in different layers of the barrel cortex from anesthetized and awake head-restrained mice. A chronic cranial window with access port allows injecting a viral vector expressing GCaMP6f or the voltage-sensitive dye (VSD) ANNINE-6plus, as well as entering the brain with a multi-channel neural probe. We present both average spontaneous activity and average evoked signals in response to multi-whisker air-puff stimulations. Time domain analysis shows the dependence of the evoked responses on the cortical layer and on the state of the animal, here separated into anesthetized, awake but resting, and running. The simultaneous data acquisition allows to compare the average membrane depolarization measured with ANNINE-6plus with the amplitude and shape of the LFP recordings. The calcium imaging data connects these data sets to the large existing database of this important second messenger. Interestingly, in the calcium imaging data, we found a few cells which showed a decrease in calcium concentration in response to vibrissa stimulation in awake mice. This system offers a multimodal technique to study the spatiotemporal dynamics of neuronal signals through a 3D architecture in vivo. It will provide novel insights on sensory coding, closing the gap between electrical and optical recordings.

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