scholarly journals Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice

2020 ◽  
Author(s):  
Hisashi Sawada ◽  
Michael K. Franklin ◽  
Jessica J. Moorleghen ◽  
Deborah A. Howatt ◽  
Masayoshi Kukida ◽  
...  
Keyword(s):  
High Frequency ◽  
Aortic Aneurysms ◽  
Aortic Diseases ◽  
Dorsal Approach ◽  
In Vivo Monitoring ◽  
Ultrasound Monitoring ◽  
Magnetic Resonance Imaging Mri ◽  
High Frequency Ultrasonography ◽  
Ct And Mri

Several modalities, such as computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound, are available to visualize mouse aortas.1-3 CT and MRI enable us to obtain reliable images of the aorta and its branches. However, CT requires vascular contrast and MRI is procedurally complex. Thus, these modalities are used only occasionally for in vivo monitoring of mouse studies. High frequency ultrasonography is a common approach for aortic monitoring in mice.4 The standard ultrasound approach using a para-sternal view can visualize the aortic root, ascending aorta, and aortic arch, while this approach cannot visualize the descending region due to the presence of lungs and ribs. Therefore, the ability to perform in vivo monitoring of descending aortic diseases in mice has been an impediment. This study reports a para-spinal dorsal approach for ultrasound imaging of mouse descending aortas.

Validation of in vivo noninvasive high-frequency ultrasonography of the arterial wall layers

2001 ◽  
Vol 27 (6) ◽  
pp. 751-756 ◽  
Author(s):  
Kenny A Rodriguez-Macias ◽  
Tord Naessen ◽  
David Bergqvist
Keyword(s):  
High Frequency ◽  
Arterial Wall ◽  
High Frequency Ultrasonography

Fluid-Solid Interaction Simulation of Flow and Stress Pattern in Thoracoabdominal Aneurysms: A Patient Specific Study

2006 ◽  
Author(s):  
Alessandro Borghi ◽  
Nigel B. Wood ◽  
Raad H. Mohiaddin ◽  
X. Yun Xu
Keyword(s):  
Wall Stress ◽  
Aortic Aneurysms ◽  
Maximum Diameter ◽  
Patient Specific ◽  
Specific Flow ◽  
Hyperelastic Materials ◽  
Abdominal Aortic ◽  
Magnetic Resonance Imaging Mri ◽  
Fluid Solid Interaction

Thoracoabdominal aneurysm (TA) is a pathology that involves the enlargement of the aortic diameter in the inferior descending thoracic aorta and has risk factors including aortic dissection, aortitis or connective tissue disorders (Webb, T. H. and Williams, G. M. 1999). Abnormal flow patterns and stress on the diseased aortic wall are thought to play an important role in the development of this pathology and the internal wall stress has proved to be more reliable as a predictor of rupture than the maximum diameter for abdominal aortic aneurysms (Fillinger, M. F., et al. 2003). In the present study, two patients with TAs of different maximum diameters were scanned using magnetic resonance imaging (MRI) techniques. Realistic models of the aneurysms were reconstructed from the in vivo MRI data acquired from the patients, and subject-specific flow conditions were applied as boundary conditions. The wall and thrombus were modeled as hyperelastic materials and their properties were derived from the literature. Fully coupled fluid-solid interaction simulations were performed for both cases using ADINA 8.2. Results were obtained for both the flow and wall stress patterns within the aneurysms. The results show that the wall stress distribution and its magnitude are strongly dependent on the 3-D shape of the aneurysm and the distribution of thrombus.

scholarly journals Diagnosis of cervical plexus tumours by high-frequency ultrasonography

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenqing Gong ◽  
Jing Wang ◽  
Liwei Huang ◽  
Xu Yang ◽  
Dingzhang Chen ◽  
...  
Keyword(s):  
High Frequency ◽  
Imaging Data ◽  
High Frequency Ultrasound ◽  
Cervical Plexus ◽  
Atypical Symptoms ◽  
Magnetic Resonance Imaging Mri ◽  
High Frequency Ultrasonography ◽  
The Right ◽  
Normal Controls ◽  
Frequency Ultrasound

Abstract Background Cervical plexus (CP) tumours are difficult to diagnose because of atypical symptoms. This study aimed to summarize the features of a normal CP and CP tumours observed on high-frequency ultrasonography. Methods The ultrasound data of 11 CP tumour patients and 22 normal volunteers were collected. All 11 patients underwent magnetic resonance imaging (MRI), and 4 patients also underwent computed tomography (CT). The imaging data were compared with surgery and pathology data. Results The C7 vertebra and bifurcation of the carotid common artery (CCA) were useful anatomic markers for identifying the CP. In contrast to the C1 nerve (22.7%), the C2-4 nerves were well displayed and thinner than the brachial plexus (P < 0.05). CP tumours were more common in females (72.7%) and generally located at C4 (72.7%) on the right side (81.8%). Additionally, the nerve trunk in tumour patients was obviously wider than that in normal controls (7.49 ± 1.03 mm vs 2.67 ± 0.36 mm, P < 0.01). Compared with pathology, the diagnostic rates of CP tumours by MRI, CT and high-frequency ultrasound were 72.7% (8/11), 25% (1/4) and 90.9% (10/11), respectively. Conclusions The diagnosis of CP neuropathy is accurate and reliable by high-frequency ultrasound, and the C7 vertebra and bifurcation of the CCA are useful anatomic markers in CP ultrasonography.

Ultra-High Frequency Ultrasound, A Promising Diagnostic Technique: Review of the Literature and Single-Center Experience

2020 ◽  
pp. 084653712094068
Author(s):  
Rossana Izzetti ◽  
Saverio Vitali ◽  
Giacomo Aringhieri ◽  
Marco Nisi ◽  
Teresa Oranges ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
High Frequency ◽  
High Spatial Resolution ◽  
Human Subjects ◽  
Diagnostic Technique ◽  
High Frequency Ultrasound ◽  
Ultra High Frequency ◽  
Musculoskeletal Anatomy ◽  
High Frequency Ultrasonography

Objectives: Ultra-high frequency ultrasonography (UHFUS) is a recently introduced diagnostic technique which finds several applications in diverse clinical fields. The range of frequencies between 30 and 100 MHz allows for high spatial resolution imaging of superficial structures, making this technique suitable for the imaging of skin, blood vessels, musculoskeletal anatomy, oral mucosa, and small parts. However, the current clinical applications of UHFUS have never been analyzed in a consistent multidisciplinary manner. The aim of this study is to revise and discuss the current applications of UHFUS in different aspects of research and clinical practice, as well as to provide some examples of the current work-in-progress carried out in our center. Materials and Methods: A literature search was performed in order to retrieve articles reporting the applications of UHFUS both in research and in clinical settings. Inclusion criteria were the use of frequencies above 30 MHz and study design conducted in vivo on human subjects. Results: In total 66 articles were retrieved. The majority of the articles focused on dermatological and vascular applications, although musculoskeletal and intraoral applications are emerging fields of use. We also describe our experience in the use of UHFUS as a valuable diagnostic support in the fields of dermatology, rheumatology, oral medicine, and musculoskeletal anatomy. Conclusion: Ultra-high frequency ultrasonography application involves an increasing number of medical fields. The high spatial resolution and the superb image quality achievable allow to foresee a wider use of this novel technique, which has the potential to bring innovation in diagnostic imaging.

In Vivo Monitoring of Human Platelets in a Humanised Rag2−/− γ-chain−/− Mouse Model

2015 ◽  
Vol 63 (S 01) ◽  
Author(s):  
C. Heim ◽  
S. Müller ◽  
B. Weigmann ◽  
M. Ramsperger-Gleixner ◽  
N. Koch ◽  
...  
Keyword(s):  
Mouse Model ◽  
Human Platelets ◽  
In Vivo Monitoring
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