Insights into molecular evolution recombination of pandemic SARS-CoV-2 using Saudi Arabian sequences

ABSTRACTThe recently emerged SARS-CoV-2 (Coronaviridae; Betacoronavirus) is the underlying cause of COVID-19 disease. Here we assessed SARS-CoV2 from the Kingdom of Saudi Arabia alongside sequences of SARS-CoV, bat SARS-like CoVs and MERS-CoV, the latter currently detected in this region. Phylogenetic analysis, natural selection investigation and genome recombination analysis were performed. Our analysis showed that all Saudi SARS-CoV-2 sequences are of the same origin and closer proximity to bat SARS-like CoVs, followed by SARS-CoVs, however quite distant to MERS-CoV. Moreover, genome recombination analysis revealed two recombination events between SARS-CoV-2 and bat SARS-like CoVs. This was further assessed by S gene recombination analysis. These recombination events may be relevant to the emergence of this novel virus. Moreover, positive selection pressure was detected between SARS-CoV-2, bat SL-CoV isolates and human SARS-CoV isolates. However, the highest positive selection occurred between SARS-CoV-2 isolates and 2 bat-SL-CoV isolates (Bat-SL-RsSHC014 and Bat-SL-CoVZC45). This further indicates that SARS-CoV-2 isolates were adaptively evolved from bat SARS-like isolates, and that a virus with originating from bats triggered this pandemic. This study thuds sheds further light on the origin of this virus.AUTHOR SUMMARYThe emergence and subsequent pandemic of SARS-CoV-2 is a unique challenge to countries all over the world, including Saudi Arabia where cases of the related MERS are still being reported. Saudi SARS-CoV-2 sequences were found to be likely of the same or similar origin. In our analysis, SARS-CoV-2 were more closely related to bat SARS-like CoVs rather than to MERS-CoV (which originated in Saudi Arabia) or SARS-CoV, confirming other phylogenetic efforts on this pathogen. Recombination and positive selection analysis further suggest that bat coronaviruses may be at the origin of SARS-CoV-2 sequences. The data shown here give hints on the origin of this virus and may inform efforts on transmissibility, host adaptation and other biological aspects of this virus.

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Type 1 Diabetes Mellitus in Saudi Arabia: A Soaring Epidemic

International Journal of Pediatrics ◽

10.1155/2018/9408370 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 15

Author(s):

Asirvatham Alwin Robert ◽

Abdulrahman Al-Dawish ◽

Muhammad Mujammami ◽

Mohamed Abdulaziz Al Dawish

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Saudi Arabia ◽

Type 1 Diabetes Mellitus ◽

Developed Countries ◽

Kingdom Of Saudi Arabia ◽

Unique Challenge ◽

The World ◽

The Developed Countries

Type 1 diabetes mellitus (T1DM) is quite prevalent in the world, with a proportion of 1 in every 300 persons and steadily rising frequency of incidence of about 3% every year. More alarmingly, the incidence of T1DM among infants is also increasing, with children as young as 6 months succumbing to it, instead of that at a rather established vulnerable age of around seven and near puberty, when the hormones antagonize the action of insulin. These reports pose a unique challenge of developing efficient T1DM management system for the young children. The Kingdom of Saudi Arabia (KSA) is the largest country in the Middle East that occupies approximately four-fifths of the Arabian Peninsula supporting a population of more than 33.3 million people, of whom 26% are under the age of 14 years. As per the Diabetes Atlas (8th edition), 35,000 children and adolescents in Saudi Arabia suffer from T1DM, which makes Saudi Arabia rank the 8th in terms of numbers of TIDM patients and 4th country in the world in terms of the incidence rate (33.5 per 100,000 individuals) of TIDM. However, in comparison with that in the developed countries, the number of research interventions on the prevalence, incidence, and the sociodemographic aspects of T1DM is woefully inadequate. In this review we discuss different aspects of T1DM in Saudi Arabia drawing on the published literature currently available.

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Pediatrics’ Total Parenteral Nutrition: Initiative and implementation of standardized formulation in Saudi Arabia

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2018.v04i03.16 ◽

2018 ◽

Vol 4 (3) ◽

pp. 492-496

Author(s):

Yousef Ahmed Alomi ◽

Hussam Saad Almalki ◽

Aisha Omar Fallatah ◽

Awatif Faraj Alshammari ◽

Nesreen Al-Shubbar

Keyword(s):

Saudi Arabia ◽

Clinical Outcome ◽

Parenteral Nutrition ◽

Drug Related Problems ◽

Kingdom Of Saudi Arabia ◽

Parental Nutrition ◽

Management Project ◽

Improve Patient ◽

New System

The national total parental nutrition program with an emphasis on pediatrics started before several ago at Ministry of health hospitals In Kingdom of Saudi Arabia. The program covered several regions and consisted from the foundation of Intravenous Admixture and preparation of pediatric parenteral nutrition to administration and follow up of patients outcomes. In addition to the prior system, the new initiative project with the standardized formulation of pediatric’s parenteral nutrition is the complementary project of the parental nutrition for pediatrics. The project initiated to prevent drug-related problems of parental nutrition, improve patient clinical outcome and reduce the unnecessary economic burden on the healthcare system. It is the new system in the Middle East and Gulf counties in additional to Saudi Arabia. The initiatives are the systemic implementation of standardized pediatrics formulation using management project tools of starting new idea until finding in the ground.

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Adult’s Total Parenteral Nutrition: Initiative and Implementation of Standardized Formulation in Saudi Arabia

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2018.v04i03.14 ◽

2018 ◽

Vol 4 (3) ◽

pp. 483-487

Author(s):

Yousef Ahmed Alomi ◽

Hussam Saad Almalki ◽

Aisha Omar Fallatah ◽

Awatif Faraj Alshammari ◽

Nahedh Rashed Alotaibi

Keyword(s):

Saudi Arabia ◽

Parenteral Nutrition ◽

Pharmacy Practice ◽

International Standards ◽

Kingdom Of Saudi Arabia ◽

Parental Nutrition ◽

International Regulations ◽

One Year ◽

New Formulation ◽

New System

The general administration of pharmaceutical care started potential pharmacy practice program. The program is part of accreditation professional’s process of national and international regulations. The adult’s parenteral nutrition was one of the critical programs. The most healthcare professionals are not familiar with the new system. The new initiatives system adult’s standardized concentration formulation of total parental nutrition as complementary to the previous one. The new formulation consisted of all parental nutrition requirements based on national and international standards. The new system can be converted as computerized physician orders. The new initiatives may implement as project management model over one year or less than that’s. The new system prevents nutrition-related problems, and medication errors, and improve clinical outcomes of the adults’ population in the Kingdom of Saudi Arabia.

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Filipino Guest Workers, Gender Segregation, and the Changing Social/Labor-Scape in the Kingdom of Saudi Arabia

MIGRATION LETTERS ◽

10.33182/ml.v16i4.796 ◽

2019 ◽

Vol 16 (4) ◽

pp. 503-512

Author(s):

Simeon S. Magliveras

Keyword(s):

Saudi Arabia ◽

Migrant Workers ◽

Major Part ◽

Gender Segregation ◽

Guest Workers ◽

Kingdom Of Saudi Arabia ◽

Gcc Countries ◽

Overseas Filipino Workers ◽

Dress Codes ◽

Social Labor

Filipinos are a major part of the workforce in the Kingdom of Saudi Arabia with a population of almost one million. This article investigates the effects of gender segregation on Filipino workers and how they navigate their lives through systems imposed on them. In particular, it examines the Kafala system (administrative sponsoring system) used for recruiting migrant workers for GCC countries. This article suggests that contrary beliefs about gender segregation and dress codes, Filipinas found it empowering. However, this article also concludes that gender segregation and dress codes also lead to isolation and loneliness. In addition, it is concluded that the fate and contentment of the overseas Filipino workers are directly dependent on who sponsors them.

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Critical Analysis of Patient and Family Rights in JCI Accreditation and Cbahi Standards for Hospitals

International Journal of Emerging Research in Management and Technology ◽

10.23956/ijermt.v6i7.234 ◽

2018 ◽

Vol 6 (7) ◽

pp. 324

Author(s):

Zuber Mujeeb Shaikh

Keyword(s):

Health Care ◽

Saudi Arabia ◽

Critical Analysis ◽

Secondary Data ◽

Joint Commission ◽

Primary Data ◽

Kingdom Of Saudi Arabia ◽

Accreditation Standards ◽

Joint Commission International ◽

Central Board

Patient and Family Rights (PFR) is a common chapter available in the Joint Commission International (JCI) Accreditation[i] (fifth edition) and Central Board for Accreditation of Healthcare Institutions (CBAHI) Standards for hospitals (second edition)[ii]. JCI Accreditation is a USA based international healthcare accrediting organization, whereas CBAHI is the Kingdom of Saudi Arabia based national health care accrediting organization. However, both these standards are accredited by Ireland based International Society for Quality in Health Care (ISQua), which is the only accrediting organization who “accredit the accreditors' in the world. In Patient and Family Rights (PFR) chapter of JCI Accreditation for hospitals, there are nineteen (19) standards and seventy-seven (77) measurable elements (ME) whereas in CBAHI Accreditation there are thirty one (31) standards, ninety nine (99) sub-standards and fifty (50) evidence(s) of compliance (EC). The scoring mechanism is totally different in both these accrediting organizations. The researcher has identified thirty two (32) common parameters from JCI Accreditation and CBAHI standards, intent statement, measurable elements, sub-standard and evidence of compliance. On the basis of these identified common parameters, the researcher has compared the Patient and Family Rights chapter in JCI Accreditation and CBAHI Standards. Methods: This is a comparison study (normative comparison) in which the researcher has critically analyzed and compared the Patient and Family Rights (PFR) standards of JCI (Joint Commission International) Accreditation of USA (United States of America) and CBAHI (Central Board for Accreditation of Healthcare Institutions) of the Kingdom of Saudi Arabia. Data Collection: Primary data are collected from the JCI Accreditation Standards for hospitals, fifth edition, 2013 and CBAHI Standards for hospitals of Kingdom of Saudi Arabia, second edition, 2011. Secondary data are collected from relevant published journals, articles, research papers, academic literature and web portals. Objectives of the Study: The aim of this study is to analyze critically Patient and Family Rights (PFR) Standards in JCI Accreditation and CBAHI Standards to point out the best in among both these standards. Conclusion: This critical analysis of Patient and Family Rights (PFR) Standards in JCI Accreditation and CBAHI Standards for hospitals clearly show that the PFR Standards in CBAHI Standards are very comprehensive than the JCI Accreditation standards.

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