scholarly journals Immunoglobulins, MHC and T Cell receptors genes in Cetaceans

2020 ◽  
Author(s):  
Francisco Gambón-Deza
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
Marine Environment ◽  
T Lymphocyte ◽  
T Cell Receptors ◽  
Immunoglobulin M ◽  
Class I ◽  
Cell Receptors ◽  
Vh Genes ◽  
Lymphocyte Receptors

AbstractCetaceans correspond to mammals that have returned to the marine environment. Adaptive changes are very significant with the conversion of the limbs into flippers. It is studied the changes that have occurred in immunoglobulins, MHC class I and II and T cell receptors genes. Constant regions of immunoglobulins are similar to those of the rest of mammals. An exception is the IgD gene, which is composed of three CH domains but CH1 similar to CH1 of immunoglobulin M. In the IGHV locus, it exist a decrease in the number of VH genes with the absence of genes within Clan I. The number of Vλ genes is greater than that of Vκ. In the genes for T lymphocyte receptors, it exists a decrease in the number of Vα genes with loss of significant clades and subclades. In Vβ and Vγ, there is also the loss of clades. These declines of Vα, Vβ and Vγ are not present Artiodactyla, and they are specific to Cetaceans. In MHC present tree evolutive lines of class I genes. These species have DQ, DR, DO and DM genes, but they are no present DP genes.

scholarly journals MHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell Receptors

2010 ◽  
Vol 6 (10) ◽  
pp. e1001149 ◽  
Author(s):  
Isabel K. Macdonald ◽  
Maria Harkiolaki ◽  
Lawrence Hunt ◽  
Timothy Connelley ◽  
A. Victoria Carroll ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
T Cell Receptors ◽  
Class I ◽  
Theileria Parva ◽  
Cell Receptors

scholarly journals Peptide–MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs)

2020 ◽  
Vol 432 (24) ◽  
pp. 166697 ◽  
Author(s):  
Yanan He ◽  
Pragati Agnihotri ◽  
Sneha Rangarajan ◽  
Yihong Chen ◽  
Melissa C. Kerzic ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
T Cell Receptors ◽  
Class Ii ◽  
Class I ◽  
Cell Receptors ◽  
Allosteric Sites

Turning Tregs into class I suppressors

Blood ◽  
2012 ◽  
Vol 119 (15) ◽  
pp. 3373-3374 ◽  
Author(s):  
Terrence L. Geiger
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Mhc Class I ◽  
T Cell Receptors ◽  
Class I ◽  
Cell Receptors ◽  
Tcr Affinity

In this issue of Blood, Plesa et al demonstrate that human Foxp3+ regulatory T cells can be redirected using MHC class I–restricted T-cell receptors (TCRs), showing a surprising lack of correlation of TCR affinity and their suppressive potency.1

scholarly journals Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.

1975 ◽  
Vol 142 (1) ◽  
pp. 197-211 ◽  
Author(s):  
H Binz ◽  
H Wigzell
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
T Cell Receptors ◽  
Parental Strain ◽  
The Other ◽  
Antigenic Determinants ◽  
Antigen Binding ◽  
F1 Hybrid ◽  
Cell Receptors

Antigen-binding receptors on T lymphocytes and IgG antibodies with the same antigen-binding specificity as the T-cell receptors display shared or identical idiotypes. This was shown using a system where adult F1 hybrid rats between two inbred strains were inoculated with T lymphocytes from one parental strain. Such F1 hybrid rats produce antibodies directed against idiotypic determinants present on IgG alloantibodies, produced in the T donor genotype strain and with specificity for the alloantigens of the other parental strain. The idiotypic nature of the F1 antialloantibody serum against the parental alloantibodies was demonstrated both by indirect hemagglutination tests or by gel diffusion using alloantisera with different specificity as targets. Furthermore, the F1 anti-T-lymphocyte sera could be shown to contain antibodies against idiotypic parental T lymphocytes as well. This was shown by the capacity of the antisera, in the presence of complement, to wipe out the relevant parental T-cell reactivity against the other parental strain (as measured in MLC or GVH) whilst leaving the T-lymphocyte reactivity against a third, unrelated allogeneic strain intact. These findings demonstrate that F1 hybrid rats inoculated with parental T lymphocytes make anti-idiotypic antibodies directed against both the T cell receptors and IgG alloantibodies of that parental strain with specificity for alloantigens of the other parental strain. In order to prove identity between the anti-idiotypic antibodies against the B and T-cell antigen-binding molecules the following experiments were carried out; highly purified IgG from relevant alloantibody-containing serum in immunosorbent from could be shown to selectively remove both anti-idiotypic activities from the F1 antiserum. Further more, parental normal T lymphocytes could be shown capable of removing from the anti-idiotypic antisera all those antibodies that would cause agglutination of the relevant alloantibody-coated erythrocytes in the indirect agglutination assay. We would thus conclude that T and B lymphocytes reactive against a given antigenic determinant use receptors with antigen-binding areas coded for by the same variable gene subset(s).

Diversity of T cell receptors specific for the VSV antigenic peptide (N52-59) Bound by the H-2Kb class I molecule

1995 ◽  
Vol 160 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Monica Imarai ◽  
Earl C. Goyarts ◽  
Grada M. Van Bleek ◽  
Stanley G. Nathenson
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Class I ◽  
Antigenic Peptide ◽  
Cell Receptors
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