scholarly journals Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade

2021 ◽  
Author(s):  
Muhammad Ummear Raza ◽  
Digavalli V. Sivarao
Keyword(s):  
Gamma Oscillations ◽  
Female Rats ◽  
Network Activity ◽  
Multiple Time ◽  
Evoked Responses ◽  
Retest Reliability ◽  
Sensory Evoked ◽  
Test Retest Reliability ◽  
40 Hz

Rationale: Schizophrenia patients consistently show deficits in sensory-evoked broadband gamma oscillations and click-evoked entrainment at 40 Hz, called the 40 Hz auditory steady-state response (ASSR). Since such evoked oscillations depend on cortical N-methyl D-aspartic acid (NMDA)-mediated network activity, they can serve as pharmacodynamic biomarkers in the preclinical development of drug candidates engaging these circuits. However, there is little test-retest reliability data in preclinical species, a prerequisite for within-subject testing paradigms. Objectives: We investigated the long-term stability of these measures in a rodent model. Methods: Female rats with chronic epidural implants were used to record tone- and 40 Hz click-evoked responses at multiple time points and across six sessions, spread over 3 weeks. We assessed reliability using intraclass correlation coefficients (ICC). Separately, we used mixed-effects ANOVA to examine time and session effects. Individual subject variability was determined using the coefficient of variation (CV). Lastly, to illustrate the importance of long-term measure stability for within-subject testing design, we used low to moderate doses of an NMDA antagonist MK801 (0.025-0.15 mg/kg) to disrupt the evoked responses. Results: We found that 40 Hz ASSR showed good reliability (ICC=0.60-0.75) while the reliability of tone-evoked gamma ranged from poor to good (0.33-0.67). We noted time but no session effects. Subjects showed a lower variance for ASSR over tone-evoked gamma. Both measures were dose-dependently attenuated by NMDA antagonism. Conclusion: Overall, while both measures use NMDA transmission, 40 Hz ASSR showed superior psychometric properties of higher ICC and lower CV, relative to tone-evoked gamma.

The TAPS Project. 9: The Reliability of the Patient Attitude Questionnaire

1993 ◽  
Vol 162 (S19) ◽  
pp. 25-29 ◽  
Author(s):  
Graham Thornicroft ◽  
Christopher Gooch ◽  
Catherine O'Driscoll ◽  
Sawsan Reda
Keyword(s):  
Living Arrangements ◽  
Psychiatric Patients ◽  
Kappa Coefficient ◽  
Attitudinal Change ◽  
Attitude Questionnaire ◽  
Retest Reliability ◽  
Patient Attitude ◽  
The Mean ◽  
Test Retest Reliability

The development of the hospital and community versions of the Patient Attitude Questionnaire is described. The instrument rates the attitudes of psychiatric patients towards their treatment settings and staff, and is framed specifically to assess attitudinal change during the transfer of patients from hospital. For the items rated using the kappa coefficient of agreement, the mean test-retest reliability value was 0.51, and the average inter-rater value was 0.82. This study shows that long-term psychiatric patients are able to give clear and consistent views about their living arrangements - views that should be sought and respected by staff.

scholarly journals Long-Term Test–Retest Reliability of Striatal and Extrastriatal Dopamine D2/3 Receptor Binding: Study with [11C]Raclopride and High-Resolution PET

2015 ◽  
Vol 35 (7) ◽  
pp. 1199-1205 ◽  
Author(s):  
Kati Alakurtti ◽  
Jarkko J Johansson ◽  
Juho Joutsa ◽  
Matti Laine ◽  
Lars Bäckman ◽  
...  
Keyword(s):  
High Resolution ◽  
Intraclass Correlation ◽  
Binding Potential ◽  
Reference Tissue ◽  
Retest Reliability ◽  
Positron Emission ◽  
Simplified Reference Tissue Model ◽  
Test Retest Reliability

We measured the long-term test–retest reliability of [11C]raclopride binding in striatal subregions, the thalamus and the cortex using the bolus-plus-infusion method and a high-resolution positron emission scanner. Seven healthy male volunteers underwent two positron emission tomography (PET) [11C]raclopride assessments, with a 5-week retest interval. D2/3 receptor availability was quantified as binding potential using the simplified reference tissue model. Absolute variability (VAR) and intraclass correlation coefficient (ICC) values indicated very good reproducibility for the striatum and were 4.5%/0.82, 3.9%/0.83, and 3.9%/0.82, for the caudate nucleus, putamen, and ventral striatum, respectively. Thalamic reliability was also very good, with VAR of 3.7% and ICC of 0.92. Test-retest data for cortical areas showed good to moderate reproducibility (6.1% to 13.1%). Our results are in line with previous test–retest studies of [11C]raclopride binding in the striatum. A novel finding is the relatively low variability of [11C]raclopride binding, providing suggestive evidence that extrastriatal D2/3 binding can be studied in vivo with [11C]raclopride PET to be verified in future studies.

Long-term test-retest reliability of the P3 NoGo wave and two independent components decomposed from the P3 NoGo wave in a visual Go/NoGo task

2013 ◽  
Vol 89 (1) ◽  
pp. 106-114 ◽  
Author(s):  
Jan Ferenc Brunner ◽  
Tor Ivar Hansen ◽  
Alexander Olsen ◽  
Toril Skandsen ◽  
Asta Håberg ◽  
...  
Keyword(s):  
Retest Reliability ◽  
Independent Components ◽  
Test Retest Reliability

scholarly journals Long-term test–retest reliability of delayed reward discounting in adolescents

2015 ◽  
Vol 111 ◽  
pp. 55-59 ◽  
Author(s):  
Andrey P. Anokhin ◽  
Simon Golosheykin ◽  
Richard C. Mulligan
Keyword(s):  
Retest Reliability ◽  
Delayed Reward ◽  
Delayed Reward Discounting ◽  
Test Retest Reliability

Test-Retest Reliability of the Vestibular Sensory-Evoked Potential (VsEP) in C57BL/6J Mice

2015 ◽  
Vol 26 (01) ◽  
pp. 059-067 ◽  
Author(s):  
Julie A. Honaker ◽  
Choongheon Lee ◽  
Robin E. Criter ◽  
Timothy A. Jones
Keyword(s):  
Response Latency ◽  
Evoked Potential ◽  
Optimal Placement ◽  
Electrode Placement ◽  
Absolute Difference ◽  
Retest Reliability ◽  
Sensory Evoked Potential ◽  
Skin Electrodes ◽  
Sensory Evoked ◽  
Test Retest Reliability

Background: The vestibular sensory-evoked potential (VsEP) is an electrical potential that provides a direct test of vestibular function in animals. VsEP recordings are carried out using subcutaneous stainless steel electrodes placed over the nuchal crest (noninverting), behind either the left or right pinna (inverting), and at the hip (ground). A noninvasive head clip is used to secure the head to a mechanical shaker for delivery of a linear vestibular stimulus measured in units of jerk (g/msec). Frequent repositioning of the noninvasive head clip and skin electrodes may be necessary during recording for particular protocols; however, the test-retest reliability of the VsEP response (latency, amplitude, and threshold) has not been determined. Purpose: The purpose of this study was to determine the possible effects of frequent repositioning of the noninvasive head clip and skin electrodes on VsEP response parameters (latencies, amplitudes, and thresholds). We hypothesize that the VsEP response will remain stable and reliable with such repeated measurements in a given animal across time. Research Design: Linear VsEP responses were recorded from ten C57 mice (ages: 2.45 mo ±0.20; weights: 17.94 g ±1.51). Two standard threshold protocols and four repeated VsEP measurements at +6 dB re: 1.0 g/msec were performed, with four selected time points of head clip repositioning. In addition, three novice investigators performed measurements of noninverting electrode placement and head clip positioning. Results: VsEP response latency, amplitude, and threshold means did not significantly change with frequent repositioning of the head clip and skin electrodes; however, increased variability was observed. Conclusions: The findings demonstrate that repositioning does not introduce significant changes in mean parameter values of the recorded VsEP response waveform; however, mean absolute difference calculations demonstrated that frequent repositioning increased response variance. For VsEP protocols requiring frequent repositioning, standardized electrode montage, optimal placement of the noninverting electrode at the nuchal crest, and increased sample size are suggested.

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