scholarly journals Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling

2021 ◽  
Author(s):  
Yan Xiao ◽  
Laura J Hoodless ◽  
Luigi Petrucco ◽  
Ruben Portugues ◽  
Tim Czopka
Keyword(s):  
Neural Circuit ◽  
Precursor Cells ◽  
Retinal Ganglion ◽  
Oligodendrocyte Precursor Cells ◽  
Precise Control ◽  
Oligodendrocyte Precursor ◽  
Zebrafish Optic Tectum ◽  
And Function ◽  
Fine Tune ◽  
Ganglion Cell Axon

Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity, and in consequence impaired visual acuity. Therefore, OPCs fine-tune neural circuit structure and function independently of their canonical role to make myelin.

Control of axonophilic migration of oligodendrocyte precursor cells by Eph–ephrin interaction

2004 ◽  
Vol 1 (1) ◽  
pp. 73-83 ◽  
Author(s):  
LAETITIA PRESTOZ ◽  
ELLI CHATZOPOULOU ◽  
GREGORY LEMKINE ◽  
NATHALIE SPASSKY ◽  
BARBARA LEBRAS ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cells ◽  
Precursor Cells ◽  
Eph Receptors ◽  
Retinal Ganglion ◽  
Oligodendrocyte Precursor Cells ◽  
Matrix Cell ◽  
Ephb Receptors ◽  
Ephrin Ligands ◽  
Oligodendrocyte Precursor

The migration of oligodendrocyte precursor cells (OPCs) is modulated by secreted molecules in their environment and by cell–cell and matrix–cell interactions. Here, we ask whether membrane-anchored guidance cues, such as the ephrin ligands and their Eph receptors, participate in the control of OPC migration in the optic nerve. We postulate that EphA and EphB receptors, which are expressed on axons of retinal ganglion cells, interact with ephrins on the surface of OPCs. We show the expression of ephrinA5, ephrinB 2 and ephrinB3 in the migrating OPCs of the optic nerve as well as in the diencephalic sites from where they originate. In addition, we demonstrate that coated EphB2-Fc receptors, which are specific for ephrinB2/B3 ligands, induce dramatic changes in the contact and migratory properties of OPCs, indicating that axonal EphB receptors activate ephrinB signaling in OPCs. Based on these findings, we propose that OPCs are characterized by an ephrin code, and that Eph–ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts, and the progress and arrest of their migration.

scholarly journals The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137311 ◽  
Author(s):  
Frank Maus ◽  
Dominik Sakry ◽  
Fabien Binamé ◽  
Khalad Karram ◽  
Krishnaraj Rajalingam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor ◽  
Ng2 Proteoglycan

Nuclear receptors and differentiation of oligodendrocyte precursor cells

2021 ◽  
pp. 389-407
Author(s):  
Vito Antonio Baldassarro ◽  
Alessandra Flagelli ◽  
Michele Sannia ◽  
Laura Calzà
Keyword(s):  
Nuclear Receptors ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells

Glia ◽  
2018 ◽  
Vol 67 (4) ◽  
pp. 688-702 ◽  
Author(s):  
Tingting Zhang ◽  
Peipei Chen ◽  
Wei Li ◽  
Sha Sha ◽  
Ya Wang ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

Intracellular ion signaling influences myelin basic protein synthesis in oligodendrocyte precursor cells

Cell Calcium ◽  
2016 ◽  
Vol 60 (5) ◽  
pp. 322-330 ◽  
Author(s):  
Maike Friess ◽  
Jens Hammann ◽  
Petr Unichenko ◽  
Heiko J. Luhmann ◽  
Robin White ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor
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