scholarly journals Novelty-induced frontal-STN networks in Parkinson's disease

2021 ◽  
Author(s):  
Rachel C Cole ◽  
Arturo I Espinoza ◽  
Arun Singh ◽  
Joel I Berger ◽  
James F Cavanagh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Control ◽  
Low Frequency ◽  
Control Mechanisms ◽  
Cortical Circuits ◽  
New Information ◽  
Novelty Response ◽  
Insight Into ◽  
Deep Brain

Evaluating and responding to new information requires cognitive control. Here, we studied novelty-response mechanisms in Parkinson's disease (PD). In PD patient-volunteers, we recorded from cortical circuits with scalp-based electroencephalography (EEG) and from subcortical circuits using intraoperative neurophysiology during surgeries for implantation of deep-brain stimulation (DBS) electrodes. We report three major results. First, novel auditory stimuli triggered midfrontal ~4-Hz rhythms, which were attenuated in PD patients but were not linked with cognitive function or novelty-associated slowing. Second, 32% of subthalamic nucleus (STN) neurons were response-modulated; nearly all (94%) of these were also modulated by novel stimuli. Finally, response-modulated STN neurons were coherent with midfrontal low-frequency activity. These findings link scalp-based measurements of neural activity with neuronal activity in the STN. Our results provide insight into midfrontal cognitive control mechanisms and how hyperdirect circuits evaluate new information.

scholarly journals The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease

Neurosignals ◽  
2013 ◽  
Vol 21 (1-2) ◽  
pp. 89-98 ◽  
Author(s):  
Gaia Giannicola ◽  
Manuela Rosa ◽  
Sara Marceglia ◽  
Emma Scelzo ◽  
Lorenzo Rossi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Local Field ◽  
Brain Stimulation ◽  
Low Frequency ◽  
Low Frequency Oscillations ◽  
Deep Brain

scholarly journals The Effect of Parkinson's Disease on the Dynamics of On-line and Proactive Cognitive Control during Action Selection

2010 ◽  
Vol 22 (9) ◽  
pp. 2058-2073 ◽  
Author(s):  
Scott A. Wylie ◽  
K. Richard Ridderinkhof ◽  
Theodore R. Bashore ◽  
Wery P. M. van den Wildenberg
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Cognitive Control ◽  
Incorrect Response ◽  
Motor Symptom ◽  
Control Mechanisms ◽  
Proactive Control ◽  
On Line ◽  
Response Activation

Processing irrelevant visual information sometimes activates incorrect response impulses. The engagement of cognitive control mechanisms to suppress these impulses and make proactive adjustments to reduce the future impact of incorrect impulses may rely on the integrity of frontal–basal ganglia circuitry. Using a Simon task, we investigated the effects of basal ganglia dysfunction produced by Parkinson's disease (PD) on both on-line (within-trial) and proactive (between-trial) control efforts to reduce interference produced by the activation of an incorrect response. As a novel feature, we applied distributional analyses, guided by the activation–suppression model, to differentiate the strength of incorrect response activation and the proficiency of suppression engaged to counter this activation. For situations requiring on-line control, PD (n = 52) and healthy control (n = 30) groups showed similar mean interference effects (i.e., Simon effects) on reaction time (RT) and accuracy. Distributional analyses showed that although the strength of incorrect response impulses was similar between the groups PD patients were less proficient at suppressing these impulses. Both groups demonstrated equivalent and effective proactive control of response interference on mean RT and accuracy rates. However, PD patients were less effective at reducing the strength of incorrect response activation proactively. Among PD patients, motor symptom severity was associated with difficulties in on-line, but not in proactive, control of response impulses. These results suggest that basal ganglia dysfunction produced by PD has selective effects on cognitive control mechanisms engaged to resolve response conflict, with primary deficits in the on-line suppression of incorrect responses occurring in the context of a relatively spared ability to adjust control proactively to minimize future conflict.

Stuttering in Parkinson’s disease after deep brain stimulation: A note on dystonia and low-frequency stimulation

2018 ◽  
Vol 50 ◽  
pp. 150-151
Author(s):  
Marcelo D. Mendonça ◽  
Raquel Barbosa ◽  
Alexandra Seromenho-Santos ◽  
Carla Reizinho ◽  
Paulo Bugalho
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Low Frequency ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Deep Brain

scholarly journals Effect of deep brain stimulation on vocal motor control mechanisms in Parkinson's disease

2019 ◽  
Vol 63 ◽  
pp. 46-53 ◽  
Author(s):  
Roozbeh Behroozmand ◽  
Karim Johari ◽  
Ryan M. Kelley ◽  
Efthymia C. Kapnoula ◽  
Nandakumar S. Narayanan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Control ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Control Mechanisms ◽  
Deep Brain

Low-frequency subthalamic nucleus deep brain stimulation for axial symptoms in advanced Parkinson’s disease

2013 ◽  
Vol 260 (9) ◽  
pp. 2306-2311 ◽  
Author(s):  
Christos Sidiropoulos ◽  
Richard Walsh ◽  
Christopher Meaney ◽  
Y. Y. Poon ◽  
Melanie Fallis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Low Frequency ◽  
Advanced Parkinson’S Disease ◽  
Axial Symptoms ◽  
Deep Brain

scholarly journals Deep Brain Stimulation Frequency of the Subthalamic Nucleus Affects Phonemic and Action Fluency in Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Valéria de Carvalho Fagundes ◽  
Carlos R. M. Rieder ◽  
Aline Nunes da Cruz ◽  
Bárbara Costa Beber ◽  
Mirna Wetters Portuguez
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
High Frequency ◽  
Verbal Fluency ◽  
Low Frequency ◽  
Stn Dbs ◽  
Deep Brain

Introduction.Deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson’s disease (PD) has been linked to a decline in verbal fluency. The decline can be attributed to surgical effects, but the relative contributions of the stimulation parameters are not well understood. This study aimed to investigate the impact of the frequency of STN-DBS on the performance of verbal fluency tasks in patients with PD.Methods.Twenty individuals with PD who received bilateral STN-DBS were evaluated. Their performances of verbal fluency tasks (semantic, phonemic, action, and unconstrained fluencies) upon receiving low-frequency (60 Hz) and high-frequency (130 Hz) STN-DBS were assessed.Results.The performances of phonemic and action fluencies were significantly different between low- and high-frequency STN-DBS. Patients showed a decrease in these verbal fluencies for high-frequency STN-DBS.Conclusion.Low-frequency STN-DBS may be less harmful to the verbal fluency of PD patients.

scholarly journals Theta Oscillations at Subthalamic Region Predicts Hypomania State After Deep Brain Stimulation in Parkinson's Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Yi-Chieh Chen ◽  
Hau-Tieng Wu ◽  
Po-Hsun Tu ◽  
Chih-Hua Yeh ◽  
Tzu-Chi Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Emotional Processing ◽  
Motor Impairment ◽  
Field Potential ◽  
Low Frequency ◽  
Patient Specific ◽  
Deep Brain

Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for the motor impairments of patients with advanced Parkinson's disease. However, mood or behavioral changes, such as mania, hypomania, and impulsive disorders, can occur postoperatively. It has been suggested that these symptoms are associated with the stimulation of the limbic subregion of the STN. Electrophysiological studies demonstrate that the low-frequency activities in ventral STN are modulated during emotional processing. In this study, we report 22 patients with Parkinson's disease who underwent STN DBS for treatment of motor impairment and presented stimulation-induced mood elevation during initial postoperative programming. The contact at which a euphoric state was elicited by stimulation was termed as the hypomania-inducing contact (HIC) and was further correlated with intraoperative local field potential recorded during the descending of DBS electrodes. The power of four frequency bands, namely, θ (4–7 Hz), α (7–10 Hz), β (13–35 Hz), and γ (40–60 Hz), were determined by a non-linear variation of the spectrogram using the concentration of frequency of time (conceFT). The depth of maximum θ power is located approximately 2 mm below HIC on average and has significant correlation with the location of contacts (r = 0.676, p < 0.001), even after partializing the effect of α and β, respectively (r = 0.474, p = 0.022; r = 0.461, p = 0.027). The occurrence of HIC was not associated with patient-specific characteristics such as age, gender, disease duration, motor or non-motor symptoms before the operation, or improvement after stimulation. Taken together, these data suggest that the location of maximum θ power is associated with the stimulation-induced hypomania and the prediction of θ power is frequency specific. Our results provide further information to refine targeting intraoperatively and select stimulation contacts in programming.

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