scholarly journals Feeding Activated Bifidobacterium infantis EVC001 to Very Low Birth Weight Infants is Associated with Significant Reduction in Rates of Necrotizing Enterocolitis

2021 ◽  
Author(s):  
Joseph Tobias ◽  
Amy Olyaei ◽  
Brian Laraway ◽  
Brian K. Jordan ◽  
Stephanie Dickinson ◽  
...  
Keyword(s):  
Risk Reduction ◽  
Necrotizing Enterocolitis ◽  
Very Low Birth Weight ◽  
Number Needed To Treat ◽  
Low Birth Weight Infants ◽  
Bifidobacterium Infantis ◽  
Exact Test ◽  
Vlbw Infants ◽  
Adjusted Risk ◽  
Related Mortality

Objectives: To assess the effects of Bifidobacterium infantis EVC001 administration on the rate of necrotizing enterocolitis (NEC) in preterm infants in a single Level IV NICU. Study Design: This was a retrospective observational analysis of 2 cohorts of VLBW infants (+/- B. infantis EVC001 probiotic) at OHSU from 2014 to 2020. Outcomes included NEC rates and NEC-associated mortality, including subgroup analysis of ELBW infants. Fishers exact test and log binomial models were used to determine differences between cohorts and risk reduction of NEC. Adjusted number needed to treat was calculated from the cohort coefficient of the model. Results: In this analysis of 483 infants, the difference in rates of NEC between cohorts was statistically significant (11.0% vs. 2.7%, P = 0.0008). The EVC001-fed cohort had a 73% risk reduction of NEC compared to the No EVC001 cohort (adjusted risk ratio 0.270, 95% CI 0.094, 0.614, P = 0.0054) resulting in an adjusted number needed to treat of 12.4 (95% CI 10.0, 23.5) for B. infantis EVC001. There was no NEC-related mortality in the EVC001-fed cohort, yielding statistically significant differences from the No EVC001 cohort overall (0% vs. 2.7%, P = 0.0274) and the ELBW subgroup (0% vs. 5.6%, P = 0.0468). Conclusion(s): B. infantis EVC001 feeding was associated with a significant reduction in the rate of NEC and NEC-related mortality in an observational study of 483 VLBW infants. B. infantis EVC001 supplementation may be considered safe and effective for reducing morbidity and mortality in the NICU.

scholarly journals Efficacy of Bifidobacterium Species in Prevention of Necrotizing Enterocolitis in Very-Low Birth Weight Infants. A Systematic Review

2019 ◽  
Vol 24 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Paige C. Hagen ◽  
Jessica W. Skelley
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Vlbw Infants ◽  
Bifidobacterium Species ◽  
Central Registry

Necrotizing enterocolitis (NEC) is one of the most common and serious gastrointestinal diseases in preterm infants. The aim of this systematic review examines the effects of probiotics on preventing NEC in very-low birth weight (VLBW) infants with a focus on the Bifidobacterium species and its strains. A systematic review of randomized trials and retrospective studies analyzing the use of probiotics to prevent NEC in VLBW infants was conducted using PubMed, Cochrane Central Registry of Controlled Trials, and Google Scholar (1996–2016). Trials reporting NEC involving preterm infants who were given Bifidobacterium alone in the first month of life were included in the systematic review. Nine studies were suitable for inclusion. Nine studies involving VLBW infants were analyzed for strain specific effects of Bifidobacterium for the prevention of NEC ≥ Stage II. B breve showed some benefit in infants < 34 weeks GA with relative risk (RR) of 0.43 (95% confidence interval [CI]: 0.21–0.87) p = 0.019, but not in neonates < 28 weeks. B lactis greatly reduced the incidence of NEC with a RR 0.11 (95% CI: 0.03–0.47), p = < 0.001. B bifidum was not widely studied but resulted in no cases of NEC. Bifidobacterium proved to be statistically significant in reducing the incidence of NEC in preterm infants.

Reduced Formula Intake with Donor Milk (DM) Impacts Necrotizing Enterocolitis (NEC) in Very Low Birth Weight (VLBW) Infants:

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 443A-443A
Author(s):  
Jennifer S. Wicks ◽  
Anita L. Esquerra-Zwiers ◽  
Laura M. Rogers ◽  
Celina M. Scala ◽  
Shirley Chen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Very Low Birth Weight ◽  
Donor Milk ◽  
Vlbw Infants

scholarly journals A Clinical Analysis of Physical and Neurological Development in very Low Birth Weight Infants with MEIR (Massage, Exercises, Intelligence training, and Rehabilitation training)

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Yonghong Deng ◽  
Shulian Wang ◽  
Zhaohui Liu ◽  
Qi Liao ◽  
Yan Zeng
Keyword(s):  
Growth And Development ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Clinical Analysis ◽  
Psychomotor Development ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Vlbw Infants ◽  
Development Index ◽  
Rehabilitation Training

Objective: This study aimed to investigate the application of MEIR (Massage, Exercises, Intelligence training, and Rehabilitation training) in Chinese VLBW infants and to observe its effects on infants’ growth and development. Methods: Clinical data of 92 VLBW infants who were treated at the neonatal intensive care unit (NICU) of Loudi Central Hospital were retrospectively analyzed. The patients were grouped as the MEIR group (n=47) and controls (n=45). Physical and neurodevelopment development were compared between the two groups. Results: There were differences in height and weight and head circumference between the two groups at all corrected ages (all P<0.05). Abnormal motions, reflexes, muscular tension, audio-visual reactions, and posture, and the total numbers of abnormalities of 3-, 6-, 9- and 12-corrected month-old infants in the MEIR group were lower than in the control group (all P<0.05). The mental development index and psychomotor development index of 6- and 12- corrected month infants in the MEIR group were higher than in the control group (all P<0.05). Conclusion: MEIR could improve the physical and neurological developments of VLBW infants, reduce the incidence of adverse events, and improve their growth and development.

scholarly journals Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Zheng ◽  
Hua Wang
Keyword(s):  
Necrotizing Enterocolitis ◽  
Very Low Birth Weight ◽  
University Hospital ◽  
Preterm Neonates ◽  
Control Group ◽  
Platelet To Lymphocyte Ratio ◽  
Retrospective Case ◽  
Low Birth Weight Infants ◽  
Intestinal Necrosis ◽  
Lymphocyte Ratio

Introduction: Necrotizing enterocolitis (NEC) is a fatal condition for very-low-birth-weight infants. Necrotizing enterocolitis is a multi-factor phenomenon that results in intestinal mucosal damage and leads to intestinal necrosis. However, sensitive laboratory indicators for NEC are lacking, making early diagnosis difficult. This study aimed to explore the relationship between the platelet-to-lymphocyte ratio (PLR) and NEC in preterm neonates to enable an earlier diagnosis of the condition.Methods: This was a retrospective case–control study of preterm neonates diagnosed with NEC between January 2018 and December 2019 in the West China Second University Hospital. Controls were selected from preterm neonatal intensive care unit (NICU) graduates, and they were matched for gestation and year of birth to the preterms diagnosed without NEC. In total, 93 and 107 infants were included in the NEC and control groups, respectively. Empowerstats analysis was used to identify the association between PLR and preterm NEC.Results: The NEC group had significantly higher PLR levels than the control group. PLR &gt; 100 within 1 week before NEC diagnosis was a risk factor for NEC. There was a positive connection between PLR and preterm NEC. A PLR of &gt;100 was determined as the optimal cutoff for predicting preterm NEC, with patients with PLR &gt;100 having a higher risk of NEC [odds ratio (OR): 18.82 (95% confidence interval (CI): 2.93–120.98), p = 0.002].Conclusions: A PLR of &gt;100 within 1 week after clinical abnormalities is associated with a high risk of NEC in preterm neonates.

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