scholarly journals First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064nm using superconducting nanowire single photon detectors

Author(s):  
Chien-Sing Poon ◽  
Dharminder S. Langri ◽  
Benjamin Rinehart ◽  
Timothy M. Rambo ◽  
Aaron J. Miller ◽  
...  

Recently proposed time-gated DCS (TG-DCS) has significant advantages compared to conventional CW-DCS, but it is still in an early stage and clinical capability has yet to be established. The main challenge for TG-DCS is the lower SNR when gating for the deeper travelling late photons. Longer wavelengths, such as 1064nm have a smaller effective attenuation coefficient and a higher power threshold in humans, which significantly increases the SNR. Here, we demonstrate the clinical utility of TG-DCS at 1064 nm in a case study on a patient with severe traumatic brain injury admitted to the neuroscience intensive care unit (NSICU). We showed a significant correlation between TG-DCS early (ρ = 0.67) and late (ρ = 0.76) gated against invasive thermal diffusion flowmetry. We also analyzed TG-DCS at high temporal resolution (50 Hz) to elucidate pulsatile flow data. Overall, this study demonstrates the first clinical translation capability of the TG-DCS system at 1064nm using superconducting nanowire single photon detector.

2014 ◽  
Vol 22 (23) ◽  
pp. 28783 ◽  
Author(s):  
Taro Yamashita ◽  
Dengkuan Liu ◽  
Shigehito Miki ◽  
Johtaro Yamamoto ◽  
Tokuko Haraguchi ◽  
...  

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 1096
Author(s):  
Jean-Michel Gérard ◽  
Anna Mukhtarova ◽  
Luca Redaelli ◽  
Houssaine Machhadani ◽  
Eva Monroy ◽  
...  

In the field of quantum technologies, the superconducting nanowire single photon detector [...]


2020 ◽  
Vol 237 ◽  
pp. 07010
Author(s):  
Mingjia Shangguan ◽  
Haiyun Xia ◽  
Xiankang Dou ◽  
Jiawei Qiu ◽  
Chao Yu

Taking advantage of the 1.5 μm lidar, a series of 1.5 μm micro-pulse lidars have been developed at the University of Science and Technology of China, in Hefei, China. According to the different characteristics of three kinds of single-photon detectors at 1.5 μm, namely superconducting nanowire single-photon detector, up-conversion SPDs and InGaAs/InP single-photon avalanche diodes, different kinds of lidar systems have been constructed to realize the detection of atmospheric visibility, cloud, depolarization, wind field at the atmospheric boundary layer.


2018 ◽  
Vol 190 ◽  
pp. 02004
Author(s):  
Gregory Goltsman

We show the design, a history of development as well as the most successful and promising approaches for QPICs realization based on hybrid nanophotonic-superconducting devices, where one of the key elements of such a circuit is a waveguide integrated superconducting single-photon detector (WSSPD). The potential of integration with fluorescent molecules is discussed also.


Nanophotonics ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2673-2692
Author(s):  
Lixing You

AbstractThe superconducting nanowire single-photon detector (SNSPD) is a quantum-limit superconducting optical detector based on the Cooper-pair breaking effect by a single photon, which exhibits a higher detection efficiency, lower dark count rate, higher counting rate, and lower timing jitter when compared with those exhibited by its counterparts. SNSPDs have been extensively applied in quantum information processing, including quantum key distribution and optical quantum computation. In this review, we present the requirements of single-photon detectors from quantum information, as well as the principle, key metrics, latest performance issues, and other issues associated with SNSPD. The representative applications of SNSPDs with respect to quantum information will also be covered.


2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Taro Yamashita ◽  
Kentaro Waki ◽  
Shigehito Miki ◽  
Robert A. Kirkwood ◽  
Robert H. Hadfield ◽  
...  

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