dbGSRV: a manually curated database of genetic susceptibility to respiratory virus

Human genetics has been proposed to play an essential role in inter-individual differences in respiratory virus infection occurrence and outcomes. To systematically understand human genetic contributions to respiratory virus infection, we developed the database dbGSRV, a manually curated database that integrated the host genetic susceptibility and severity studies of respiratory viruses scattered over literatures in PubMed. At present, dbGSRV contains 1932 records of genetic association studies relating 1010 unique variants and seven respiratory viruses, manually curated from 168 published articles. Users can access the records by quick searching, batch searching, advanced searching and browsing. Reference information, infection status, population information, mutation information and disease relationship are provided for each record, as well as hyper links to public databases in convenient of users accessing more information. In addition, a visual overview of the topological network relationship between respiratory viruses and associated genes is provided. Therefore, dbGSRV offers a promising avenue to facilitate researchers to dissect human factors in respiratory virus infection, define novel drug targets, conduct risk stratification of population and develop personalized medicine approaches. Database URL: http://www.ehbio.com/dbGSRV/front/

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Detection of Respiratory Viruses Among Pilgrims in Saudi Arabia During the Time of a Declared Influenza A(H1N1) Pandemic

Journal of Travel Medicine ◽

10.1111/j.1708-8305.2011.00575.x ◽

2011 ◽

Vol 19 (1) ◽

pp. 15-21 ◽

Cited By ~ 50

Author(s):

Ziad A. Memish ◽

Abdullah M. Assiri ◽

Raheela Hussain ◽

Ibrahim Alomar ◽

Gwen Stephens

Keyword(s):

Virus Infection ◽

Pandemic Influenza ◽

Influenza A ◽

Respiratory Virus ◽

Preventive Measures ◽

Respiratory Viruses ◽

H1n1 Vaccine ◽

Increased Risk ◽

Influenza A H1n1 ◽

Respiratory Virus Infection

Abstract Background The objectives of this study were to determine whether pilgrim attendance at the Hajj was associated with an increased risk of acquiring influenza, and other respiratory viruses, and to evaluate the compliance of pilgrims with influenza vaccination and other recommended preventive measures. Methods A cross-sectional survey was conducted among pilgrims as they arrived at the King Abdulaziz International Airport in Jeddah for the 2009 Hajj and as they departed from the same airport during the week after the Hajj. Nasopharyngeal and throat swabs were tested for 18 respiratory virus types and subtypes using the xTAG Respiratory Viral Panel FAST assay. Results A total of 519 arriving pilgrims and 2,699 departing pilgrims were examined. Their mean age was 49 years and 58% were male. In all, 30% of pilgrims stated that they had received pandemic influenza A(H1N1) vaccine before leaving for the Hajj and 35% of arriving pilgrims reported wearing a face mask. Only 50% of arriving pilgrims were aware of preventive measures such as hand hygiene and wearing a mask. The prevalence of any respiratory-virus infection was 14.5% (12.5% among arriving pilgrims and 14.8% among departing pilgrims). The main viruses detected (both groups combined) were rhinovirus-enterovirus (N = 414, 12.9%), coronaviruses (N = 27, 0.8%), respiratory syncytial virus (N = 8, 0.2%), and influenza A virus (N = 8, 0.2%) including pandemic influenza A(H1N1) (N = 3, 0.1%). The prevalence of pandemic influenza A(H1N1) was 0.2% (N = 1) among arriving pilgrims and 0.1% (N = 2) among departing pilgrims. The prevalence of any respiratory virus infection was lower among those who said they received H1N1 vaccine compared to those who said they did not receive it (11.8% vs 15.6%, respectively, p = 0.009). Conclusion We found very low pandemic influenza A(H1N1) prevalence among arriving pilgrims and no evidence that amplification of transmission had occurred among departing pilgrims.

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Rates of asymptomatic respiratory virus infection across age groups

Epidemiology and Infection ◽

10.1017/s0950268819000505 ◽

2019 ◽

Vol 147 ◽

Cited By ~ 9

Author(s):

M. Galanti ◽

R. Birger ◽

M. Ud-Dean ◽

I. Filip ◽

H. Morita ◽

...

Keyword(s):

New York ◽

Virus Infection ◽

Large Scale ◽

Respiratory Virus ◽

Viral Infections ◽

Age Groups ◽

Respiratory Viruses ◽

Surveillance Systems ◽

Infection Frequency ◽

Respiratory Virus Infection

AbstractRespiratory viral infections are a leading cause of disease worldwide. A variety of respiratory viruses produce infections in humans with effects ranging from asymptomatic to life-treathening. Standard surveillance systems typically only target severe infections (ED outpatients, hospitalisations, deaths) and fail to track asymptomatic or mild infections. Here we performed a large-scale community study across multiple age groups to assess the pathogenicity of 18 respiratory viruses. We enrolled 214 individuals at multiple New York City locations and tested weekly for respiratory viral pathogens, irrespective of symptom status, from fall 2016 to spring 2018. We combined these test results with participant-provided daily records of cold and flu symptoms and used this information to characterise symptom severity by virus and age category. Asymptomatic infection rates exceeded 70% for most viruses, excepting influenza and human metapneumovirus, which produced significantly more severe outcomes. Symptoms were negatively associated with infection frequency, with children displaying the lowest score among age groups. Upper respiratory manifestations were most common for all viruses, whereas systemic effects were less typical. These findings indicate a high burden of asymptomatic respiratory virus infection exists in the general population.

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Respiratory Viruses and Asthma

Seminars in Respiratory and Critical Care Medicine ◽

10.1055/s-0037-1617412 ◽

2018 ◽

Vol 39 (01) ◽

pp. 045-055 ◽

Cited By ~ 5

Author(s):

James Ramsahai ◽

Prabuddha Pathinayake ◽

Bilal Malik ◽

Nathan Bartlett ◽

Peter Wark

Keyword(s):

Virus Infection ◽

Immune Responses ◽

Respiratory Virus ◽

Respiratory Viruses ◽

Complex Interaction ◽

Respiratory Disorder ◽

Key Issues ◽

Respiratory Virus Infection ◽

The Impact ◽

The Relationship

AbstractAsthma remains the most prevalent chronic respiratory disorder, affecting people of all ages. The relationship between respiratory virus infection and asthma has long been recognized, though remains incompletely understood. In this article, we will address key issues around this relationship. These will include the crucial role virus infection plays in early life, as a potential risk factor for the development of asthma and lung disease. We will assess the impact that virus infection has on those with established asthma as a trigger for acute disease and how this may influence asthma throughout life. Finally, we will explore the complex interaction that occurs between the airway and the immune responses that make those with asthma so susceptible to the effects of virus infection.

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