scholarly journals Temporal trends of hepatitis C virus transmission in internally displaced people who inject drugs in Odessa, Ukraine

2021 ◽  
Author(s):  
Anna Yakovleva ◽  
Ganna Kovalenko ◽  
Matthew Redlinger ◽  
Pavlo Smyrnov ◽  
Olga Tymets ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
People Who Inject Drugs ◽  
Temporal Trends ◽  
Infection Prevalence ◽  
Internally Displaced ◽  
Low Resource ◽  
Internally Displaced People ◽  
Displaced People

AbstractBackgroundDue to practical challenges associated with genetic sequencing in low resource environments, the burden of hepatitis C virus (HCV) in forcibly displaced people is understudied. We examined the use of field-applicable HCV sequencing methods and phylogenetic analysis to determine HCV transmission dynamics in internally displaced people who inject drugs (IDPWID) due to war in eastern Ukraine.MethodsIn this cross-sectional study, we used modified respondent-driven sampling to recruit IDPWID who have settled in Odessa, Ukraine. We generated partial and near full length genome (NFLG) HCV sequences using Oxford Nanopore MinION in a simulated field environment. Maximum likelihood and Bayesian methods were used to establish phylodynamic relationships.FindingsBetween June and September 2020, we collected epidemiological data and whole blood samples from 164 IDPWID. Rapid testing identified an HIV, anti-HCV, and HIV/HCV co-infection prevalence of 39%, 67.7%, and 31.1%, respectively. We generated 57 partial or NFLG HCV sequences and identified eight transmission clusters, of which at least two originated within a year and a half post-migration. Unstable housing post-migration was associated with more reports of injection drug use in the past 30 days (p=0.048).InterpretationLocal generation of viral sequencing data and phylogenetic analysis in rapidly changing low-resource environments, such as those faced by forcibly displaced people, can inform timely adaptation of prevention and treatment.FundingOxford University John Fell Fund, ISS Wellcome Trust, Branco Weiss Fellowship.

Hepatitis C virus DAA treatment adherence patterns and SVR among people who inject drugs treated in opioid agonist therapy programs

2021 ◽  
Author(s):  
Moonseong Heo ◽  
Irene Pericot-Valverde ◽  
Lior Rennert ◽  
Matthew J Akiyama ◽  
Brianna L Norton ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Adherence ◽  
People Who Inject Drugs ◽  
Alcohol Intoxication ◽  
Sustained Viral Response ◽  
Time Frame ◽  
Agonist Therapy ◽  
Opioid Agonist ◽  
Direct Acting Antiviral

Abstract Background Adequate medication adherence is critical for achieving sustained viral response (SVR) of hepatitis C virus (HCV) among people who inject drugs (PWID). However, it is less known which patterns of direct-acting antiviral (DAA) treatment adherence are associated with SVR in this population or what factors are associated with each pattern. Methods The randomized three-arm PREVAIL study utilized electronic blister packs to obtain daily time frame adherence data in opiate agonist therapy program settings. Exact logistic regressions were applied to test the associations between SVR and six types of treatment adherence patterns. Results Of the 113 participants treated with combination DAAs, 109 (96.5%) achieved SVR. SVR was significantly associated with all pattern parameters except for number of switches between adherent and missed days: total adherent daily doses (exact AOR=1.12; 95%CI=1.04-1.22), percent total doses (1.09; 1.03-1.16), days on treatment (1.16; 1.05-1.32), maximum consecutive adherent days (1.34; 1.06-2.04), maximum consecutive non-adherent days (.85; .74-.95=.003). SVR was significantly associated with total adherent doses in the first two months of treatment, it was not in the last month. Compared to White participants (30.7±11.8(se)), Black (18.4±7.8) and Hispanic participants (19.2±6.1) had significantly shorter maximum consecutive adherent days. While alcohol intoxication was significantly associated with frequent switches, drug use was not associated with any adherence pattern. Conclusion Consistent maintenance of adequate total dose adherence over the entire course of HCV treatment is important in achieving SVR among PWID. Additional integrative addiction and medical care may be warranted for treating PWID experiencing alcohol intoxication.

scholarly journals Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0210724 ◽  
Author(s):  
Juliet A. Shenge ◽  
Georgina N. Odaibo ◽  
David O. Olaleye
Keyword(s):  
Phylogenetic Analysis ◽  
Hepatitis C Virus ◽  
Hepatitis C

scholarly journals Differences in the Incidence of Malaria between Internally Displaced People and General Population of Colombia from 2007 to 2016

2018 ◽  
Vol 73 ◽  
pp. 319-320
Author(s):  
A.J. Rodriguez-Morales ◽  
H.A. Bedoya-Arias ◽  
N. Sánchez-Ramírez ◽  
J.E. Bedoya-Arias ◽  
N. Hurtado-Hurtado ◽  
...  
Keyword(s):  
General Population ◽  
Internally Displaced ◽  
Internally Displaced People ◽  
Displaced People

scholarly journals Hepatitis C Virus Treatment Access Among Human Immunodeficiency Virus and Hepatitis C Virus (HCV)-Coinfected People Who Inject Drugs in Guangzhou, China: Implications for HCV Treatment Expansion

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Carissa E. Chu ◽  
Feng Wu ◽  
Xi He ◽  
Kali Zhou ◽  
Yu Cheng ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Social Workers ◽  
People Who Inject Drugs ◽  
Hiv Treatment ◽  
Direct Acting Antivirals ◽  
Hcv Treatment ◽  
Treatment Access ◽  
Immunodeficiency Virus ◽  
Direct Acting

Abstract Background.  Hepatitis C virus (HCV) treatment access among human immunodeficiency virus (HIV)/HCV-coinfected people who inject drugs is poor, despite a high burden of disease in this population. Understanding barriers and facilitators to HCV treatment uptake is critical to the implementation of new direct-acting antivirals. Methods.  We conducted in-depth interviews with patients, physicians, and social workers at an HIV treatment facility and methadone maintenance treatment centers in Guangzhou, China to identify barriers and facilitators to HCV treatment. We included patients who were in various stages of HCV treatment and those who were not treated. We used standard qualitative methods and organized data into themes. Results.  Interview data from 29 patients, 8 physicians, and 3 social workers were analyzed. Facilitators and barriers were organized according to a modified Consolidated Framework for Implementation Research schematic. Facilitators included patient trust in physicians, hope for a cure, peer networks, and social support. Barriers included ongoing drug use, low HCV disease knowledge, fragmented reimbursement systems, HIV exceptionalism, and stigma. Conclusions.  Expanding existing harm reduction programs, HIV treatment programs, and social services may facilitate scale-up of direct-acting antivirals globally. Improving integration of ancillary social and mental health services within existing HIV care systems may facilitate HCV treatment access.

The unmet needs of refugees and internally displaced people

The Lancet ◽  
2018 ◽  
Vol 392 (10164) ◽  
pp. 2530-2532 ◽  
Author(s):  
David Miliband ◽  
Mesfin Teklu Tessema
Keyword(s):  
Unmet Needs ◽  
Internally Displaced ◽  
Internally Displaced People ◽  
Displaced People

scholarly journals Hepatitis C virus infection among people who inject drugs in Bangkok, Thailand, 2005–2010

2019 ◽  
Vol 8 (1) ◽  
pp. 50 ◽  
Author(s):  
Michael Martin ◽  
Suphak Vanichseni ◽  
Wanna Leelawiwat ◽  
Rapeepan Anekvorapong ◽  
Boonyos Raengsakulrach ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
People Who Inject Drugs ◽  
Hepatitis C Virus Infection
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