scholarly journals Genomic and epidemiological monitoring of yellow fever virus transmission potential

2018 ◽  
Author(s):  
Faria N. R. ◽  
Kraemer M. U. G. ◽  
Hill S. C. ◽  
Goes de Jesus J. ◽  
de Aguiar R. S. ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Global Strategy ◽  
Fever Virus ◽  
Spatial Expansion ◽  
Sex Distribution ◽  
Transmission Potential ◽  
Epidemiological Monitoring ◽  
Age And Sex

AbstractThe yellow fever virus (YFV) epidemic that began in Dec 2016 in Brazil is the largest in decades. The recent discovery of YFV in BrazilianAedes sp.vectors highlights the urgent need to monitor the risk of re-establishment of domestic YFV transmission in the Americas. We use a suite of epidemiological, spatial and genomic approaches to characterize YFV transmission. We show that the age- and sex-distribution of human cases in Brazil is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally using a new protocol reveals an early phase of sylvatic YFV transmission restricted to Minas Gerais, followed in late 2016 by a rise in viral spillover to humans, and the southwards spatial expansion of the epidemic towards previously YFV-free areas. Our results establish a framework for monitoring YFV transmission in real-time, contributing to the global strategy of eliminating future yellow fever epidemics.

scholarly journals Genomic and epidemiological monitoring of yellow fever virus transmission potential

Science ◽  
2018 ◽  
Vol 361 (6405) ◽  
pp. 894-899 ◽  
Author(s):  
N. R. Faria ◽  
M. U. G. Kraemer ◽  
S. C. Hill ◽  
J. Goes de Jesus ◽  
R. S. Aguiar ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Global Strategy ◽  
Fever Virus ◽  
Spatial Expansion ◽  
Sex Distribution ◽  
Transmission Potential ◽  
Epidemiological Monitoring ◽  
Age And Sex

The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in BrazilianAedesspecies mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.

scholarly journals Yellow Fever Outbreak in Eastern Senegal, 2020–2021

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1475
Author(s):  
Moussa Moïse Diagne ◽  
Marie Henriette Dior Ndione ◽  
Alioune Gaye ◽  
Mamadou Aliou Barry ◽  
Diawo Diallo ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Mosquito Species ◽  
Virus Transmission ◽  
Genomic Analysis ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
World Health ◽  
Effective Vaccine ◽  
Ministry Of Health

Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3′UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.

scholarly journals Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Natalia Ingrid Oliveira Silva ◽  
Lívia Sacchetto ◽  
Izabela Maurício de Rezende ◽  
Giliane de Souza Trindade ◽  
Angelle Desiree LaBeaud ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Fever Virus

Aedes Aegypti Strain Fitness for Yellow Fever Virus Transmission *

1977 ◽  
Vol 26 (5) ◽  
pp. 985-989 ◽  
Author(s):  
Thomas H. G. Aitken ◽  
Robert E. Shope ◽  
Wilbur G. Downs
Keyword(s):  
Aedes Aegypti ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Fever Virus

scholarly journals Assessment of risk of dengue and yellow fever virus transmission in three major Kenyan cities based on Stegomyia indices

2017 ◽  
Vol 11 (8) ◽  
pp. e0005858 ◽  
Author(s):  
Sheila B. Agha ◽  
David P. Tchouassi ◽  
Armanda D. S. Bastos ◽  
Rosemary Sang
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Fever Virus

scholarly journals What Does the Future Hold for Yellow Fever Virus? (II)

2018 ◽  
Author(s):  
Raphaëlle Klitting ◽  
Carlo Fischer ◽  
Jan F. Drexler ◽  
Ernest A. Gould ◽  
David Roiz ◽  
...  
Keyword(s):  
South America ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Fever Virus ◽  
Control Measures ◽  
World Health ◽  
Epidemiological Surveillance ◽  
Tropical Regions ◽  
Vaccination Recommendation

As revealed by the recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America, YFV control measures need urgent rethinking. Over the last decade, most reported outbreaks occurred in, or eventually reached, areas of low vaccination coverage but suitable for virus transmission, with an unprecedented risk of expansion to densely populated territories in Africa, South America and Asia. As reflected in the World Health Organization’s initiative launched in 2017, it is high time to strengthen epidemiological surveillance to monitor accurately, viral dissemination and redefine vaccination recommendation areas. Vector-control and immunisation measures need to be adapted and vaccine manufacturing must be reconciled with an increasing demand. We will have to face more YF cases in the upcoming years hence, improving disease management through the development of efficient treatments will prove most beneficial. Undoubtedly, these developments will require in-depth descriptions of YFV biology at molecular, physiological and ecological levels. This second section of the two-part review describes the current state of knowledge and gaps regarding the molecular biology of YFV, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels.

scholarly journals What Does the Future Hold for Yellow Fever Virus? (II)

Genes ◽  
2018 ◽  
Vol 9 (9) ◽  
pp. 425 ◽  
Author(s):  
Raphaëlle Klitting ◽  
Carlo Fischer ◽  
Jan Drexler ◽  
Ernest Gould ◽  
David Roiz ◽  
...  
Keyword(s):  
South America ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Virus Transmission ◽  
Fever Virus ◽  
Control Measures ◽  
World Health ◽  
Epidemiological Surveillance ◽  
Tropical Regions ◽  
Vaccination Recommendation

As revealed by the recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America, YFV control measures need urgent rethinking. Over the last decade, most reported outbreaks occurred in, or eventually reached, areas with low vaccination coverage but that are suitable for virus transmission, with an unprecedented risk of expansion to densely populated territories in Africa, South America and Asia. As reflected in the World Health Organization’s initiative launched in 2017, it is high time to strengthen epidemiological surveillance to monitor accurately viral dissemination, and redefine vaccination recommendation areas. Vector-control and immunisation measures need to be adapted and vaccine manufacturing must be reconciled with an increasing demand. We will have to face more yellow fever (YF) cases in the upcoming years. Hence, improving disease management through the development of efficient treatments will prove most beneficial. Undoubtedly, these developments will require in-depth descriptions of YFV biology at molecular, physiological and ecological levels. This second section of a two-part review describes the current state of knowledge and gaps regarding the molecular biology of YFV, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels.

Sign in / Sign up

Export Citation Format

Share Document