Construction and Elaboration of Autobiographical Memories from Multiple Visual Perspectives

Mapping Intimacies ◽

10.1101/317594 ◽

2018 ◽

Cited By ~ 2

Author(s):

Heather Iriye ◽

Peggy L. St. Jacques

Keyword(s):

Functional Connectivity ◽

Autobiographical Memory ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

Fundamental Aspect ◽

Visual Perspective ◽

Autobiographical Memories ◽

Functional Mechanisms ◽

Posterior Midline

AbstractVisual perspective, recalling events from one’s own eyes or from an observer-like viewpoint, is a fundamental aspect of autobiographical memory (AM). Yet, how visual perspective influences the functional mechanisms supporting retrieval is unclear. Here, we used a multivariate neuroimaging analysis to characterize the spatiotemporal dynamics supporting AM retrieval from multiple visual perspectives. Both own eyes and observer perspectives engaged an AM retrieval network (i.e., hippocampus, anterior and posterior midline, lateral frontal and posterior cortices) that peaked during later retrieval periods but was recruited less strongly for observer perspectives. Functional connectivity analyses with an anterior hippocampal seed revealed that visual perspective also altered interactions among neural regions and their timing during retrieval. There was stronger hippocampal connectivity with a posterior medial network during the initial construction of AMs from observer perspectives and stronger connectivity with a medial temporal lobe network during later retrieval periods from own eyes perspectives, suggesting that visual perspective directs how neocortical systems guide retrieval. Our findings demonstrate that visual perspective influences AM retrieval by altering hippocampal-neocortical interactions and subsequently the strength of neural recruitment in the AM retrieval network during later retrieval periods, thereby supporting the central role of visual perspective in shaping the personal past.

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Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy

Epilepsy Research and Treatment ◽

10.1155/2014/157452 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Claudia P. Múnera ◽

Carolina Lomlomdjian ◽

Belen Gori ◽

Verónica Terpiluk ◽

Nancy Medel ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Autobiographical Memory ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

Healthy Controls ◽

Specific Probe ◽

Adolescence Period ◽

The Right ◽

Medial Temporal Lobe Epilepsy

Autobiographical memory (AM) is understood as the retrieval of personal experiences that occurred in specific time and space. To date, there is no consensus on the role of medial temporal lobe structures in AM. Therefore, we investigated AM in medial temporal lobe epilepsy (TLE) patients. Twenty TLE patients candidates for surgical treatment, 10 right (RTLE) and 10 left (LTLE), and 20 healthy controls were examined with a version of the Autobiographical Interview adapted to Spanish language. Episodic and semantic AM were analyzed during five life periods through two conditions: recall and specific probe. AM scores were compared with clinical and cognitive data. TLE patients showed lower performance in episodic AM than healthy controls, being significantly worst in RTLE group and after specific probe. In relation to semantic AM, LTLE retrieved higher amount of total semantic details compared to controls during recall, but not after specific probe. No significant differences were found between RTLE and LTLE, but a trend towards poorer performance in RTLE group was found. TLE patients obtained lower scores for adolescence period memories after specific probe. Our findings support the idea that the right hippocampus would play a more important role in episodic retrieval than the left, regardless of a temporal gradient.

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Learning and remembering real-world events after medial temporal lobe damage

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1617025113 ◽

2016 ◽

Vol 113 (47) ◽

pp. 13480-13485 ◽

Cited By ~ 26

Author(s):

Adam J. O. Dede ◽

Jennifer C. Frascino ◽

John T. Wixted ◽

Larry R. Squire

Keyword(s):

Autobiographical Memory ◽

Temporal Lobe ◽

Real World ◽

Medial Temporal Lobe ◽

University Of California ◽

Hippocampal Damage ◽

Chronological Order ◽

Control Groups ◽

The University

The hippocampus is important for autobiographical memory, but its role is unclear. In the study, patients with hippocampal damage and controls were taken on a 25-min walk on the University of California, San Diego, campus during which 11 planned events occurred. Memory was tested directly after the walk. In addition, a second group of controls took the same walk and were tested after 1 mo. Patients with hippocampal damage remembered fewer details than controls tested directly after the walk but remembered a similar number of details as controls tested after 1 mo. Notably, the details that were reported by patients had the characteristics of episodic recollection and included references to particular places and events. Patients exhibited no special difficulty remembering spatial details in comparison with nonspatial details. Last, whereas both control groups tended to recall the events of the walk in chronological order, the order in which patients recalled the events was unrelated to the order in which they occurred. The findings illuminate the role of the hippocampus in autobiographical memory and in the spatial and nonspatial aspects of episodic recollection.

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Faculty Opinions recommendation of An FMRI study of the role of the medial temporal lobe in implicit and explicit sequence learning.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012850.187153 ◽

2003 ◽

Author(s):

Wendy Suzuki

Keyword(s):

Temporal Lobe ◽

Sequence Learning ◽

Medial Temporal Lobe ◽

Fmri Study ◽

Implicit And Explicit

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The role of decreased cortical thickness and volume of medial temporal lobe structures in predicting incident psychosis in patients with Alzheimer's disease: a prospective longitudinal MRI study

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2021.04.015 ◽

2021 ◽

Author(s):

Young-Min Lee ◽

Je-Min Park ◽

Byung-Dae Lee ◽

Eunsoo Moon ◽

Hee-Jeong Jeong ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Temporal Lobe ◽

Cortical Thickness ◽

Medial Temporal Lobe ◽

Longitudinal Mri ◽

Mri Study ◽

Prospective Longitudinal

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Early stages of tau pathology and its associations with functional connectivity, atrophy and memory

Brain ◽

10.1093/brain/awab114 ◽

2021 ◽

Author(s):

David Berron ◽

Jacob W Vogel ◽

Philip S Insel ◽

Joana B Pereira ◽

Long Xie ◽

...

Keyword(s):

Functional Connectivity ◽

Entorhinal Cortex ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

Memory Impairment ◽

Memory Performance ◽

Hippocampal Atrophy ◽

Tau Pathology ◽

Β Amyloid ◽

With Memory

Abstract In Alzheimer’s disease, postmortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. Our objective was to study how medial temporal tau is related to functional connectivity, regional atrophy, and memory performance. We included 215 β-amyloid negative cognitively unimpaired, 81 β-amyloid positive cognitively unimpaired and 87 β-amyloid positive individuals with mild cognitive impairment, who each underwent [18]F-RO948 tau and [18]F-flutemetamol amyloid PET imaging, structural T1-MRI and memory assessments as part of the Swedish BioFINDER-2 study. First, event-based modelling revealed that the entorhinal cortex and area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, area 36 and the parahippocampal cortex. In later stages, tau accumulation became abnormal in neocortical temporal and finally parietal brain regions. Second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. Tau load, but not atrophy, in these regions was associated with lower memory performance. Further, tau-related reductions in functional connectivity in critical networks between the medial temporal lobe and regions in the posterior-medial system were associated with this early memory impairment. Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. In summary, our findings highlight the progression of tau pathology across medial temporal lobe subregions and its disease-stage specific association with memory performance. While tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy.

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