scholarly journals A Key For Hypoxia Genetic Adaptation In Alpaca Could Be A HIF1A Truncated bHLH Protein Domain

2018 ◽  
Author(s):  
M Daniel Moraga ◽  
Fernando A. Moraga C ◽  
Felipe Figueroa
Keyword(s):  
High Altitude ◽  
Physiological Response ◽  
Protein Domain ◽  
Bhlh Protein ◽  
Genetic Adaptation ◽  
Hypoxia Inducible Factors ◽  
Stop Codons ◽  
Bhlh Domain ◽  
Identical Nucleotide ◽  
Genetic Events

AbstractAnimals exposed to hypoxia, triggers a physiological response via Hypoxia Inducible Factors (HIF1). In this study, we have evidenced the existence of genetic events that caused the loss of most of the bHLH domain in HIF1A proteins borne by Alpaca and other members of the Cetartiodactyla superorder. In these truncate domains, some stop codons are found at identical nucleotide positions in both, Artiodactyls and Cetaceans, indicating that mutations originating the truncated domains occurs before their divergence about 55 million years ago. The relevance of this findings for adaptation of Alpacas to hypoxia of high altitude conditions are discussed.

Human Genetic Adaptation to High Altitude

2001 ◽  
Vol 2 (2) ◽  
pp. 257-279 ◽  
Author(s):  
Lorna G. Moore
Keyword(s):  
High Altitude ◽  
Genetic Adaptation

scholarly journals Oxygen sensing pathway: genetic adaptation at high‐altitude

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
MA Qadar Pasha ◽  
Aastha Mishra ◽  
Ghulam Mohammad
Keyword(s):  
High Altitude ◽  
Oxygen Sensing ◽  
Genetic Adaptation

scholarly journals Influences of Hypoxia on Hatching Performance in Chickens with Different Genetic Adaptation to High Altitude

2008 ◽  
Vol 87 (10) ◽  
pp. 2112-2116 ◽  
Author(s):  
H. Zhang ◽  
X.T. Wang ◽  
Y. Chamba ◽  
Y. Ling ◽  
C.X. Wu
Keyword(s):  
High Altitude ◽  
Genetic Adaptation

scholarly journals Down-Regulation ofEPAS1Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

2017 ◽  
pp. msw280 ◽  
Author(s):  
Yi Peng ◽  
Chaoying Cui ◽  
Yaoxi He ◽  
Ouzhuluobu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
High Altitude ◽  
Genetic Adaptation ◽  
Down Regulation ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

Recruitments of Sherpa highlanders and non-Sherpa lowlanders v1

2021 ◽  
Author(s):  
Yunden Droma ◽  
not provided Masayuki Hanaoka ◽  
not provided Masao Ota
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
High Altitude ◽  
Sea Level ◽  
Venous Blood ◽  
Genetic Adaptation ◽  
Nucleotide Polymorphisms ◽  
Research Project ◽  
Single Nucleotide ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

In order to carry out the research project of genetic adaptation to high-altitude hypoxia in Sherpa highlanders, we recruited Sherpa highlanders in Namche Bazaar village at a high altitude of 3,440 meters (m) above sea level and non-Sherpa lowlanders in Kathmandu city at 1,300 m in Nepal. Venous blood was sampled to obtain plasma and extract DNA in each subject. The concentrations of factors in plasma were measured. The single-nucleotide polymorphisms (SNPs) in the hypoxia-associated genes were genotyped.

scholarly journals A genome wide study of genetic adaptation to high altitude in feral Andean Horses of the páramo

2013 ◽  
Vol 13 (1) ◽  
pp. 273 ◽  
Author(s):  
Sher L Hendrickson
Keyword(s):  
High Altitude ◽  
Genetic Adaptation ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Study

scholarly journals Measuring high-altitude adaptation

2017 ◽  
Vol 123 (5) ◽  
pp. 1371-1385 ◽  
Author(s):  
Lorna G. Moore
Keyword(s):  
Blood Flow ◽  
Reproductive Success ◽  
High Altitude ◽  
Genome Sequencing ◽  
Genetic Adaptation ◽  
Whole Genome ◽  
Genome Scans ◽  
Future Studies ◽  
Physiological Processes ◽  
Sequencing Studies

High altitudes (>8,000 ft or 2,500 m) provide an experiment of nature for measuring adaptation and the physiological processes involved. Studies conducted over the past ~25 years in Andeans, Tibetans, and, less often, Ethiopians show varied but distinct O2transport traits from those of acclimatized newcomers, providing indirect evidence for genetic adaptation to high altitude. Short-term (acclimatization, developmental) and long-term (genetic) responses to high altitude exhibit a temporal gradient such that, although all influence O2content, the latter also improve O2delivery and metabolism. Much has been learned concerning the underlying physiological processes, but additional studies are needed on the regulation of blood flow and O2utilization. Direct evidence of genetic adaptation comes from single-nucleotide polymorphism (SNP)-based genome scans and whole genome sequencing studies that have identified gene regions acted upon by natural selection. Efforts have begun to understand the connections between the two with Andean studies on the genetic factors raising uterine blood flow, fetal growth, and susceptibility to Chronic Mountain Sickness and Tibetan studies on genes serving to lower hemoglobin and pulmonary arterial pressure. Critical for future studies will be the selection of phenotypes with demonstrable effects on reproductive success, the calculation of actual fitness costs, and greater inclusion of women among the subjects being studied. The well-characterized nature of the O2transport system, the presence of multiple long-resident populations, and relevance for understanding hypoxic disorders in all persons underscore the importance of understanding how evolutionary adaptation to high altitude has occurred.NEW & NOTEWORTHY Variation in O2transport characteristics among Andean, Tibetan, and, when available, Ethiopian high-altitude residents supports the existence of genetic adaptations that improve the distribution of blood flow to vital organs and the efficiency of O2utilization. Genome scans and whole genome sequencing studies implicate a broad range of gene regions. Future studies are needed using phenotypes of clear relevance for reproductive success for determining the mechanisms by which naturally selected genes are acting.

scholarly journals A Novel Candidate Region for Genetic Adaptation to High Altitude in Andean Populations

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125444 ◽  
Author(s):  
Guido Valverde ◽  
Hang Zhou ◽  
Sebastian Lippold ◽  
Cesare de Filippo ◽  
Kun Tang ◽  
...  
Keyword(s):  
High Altitude ◽  
Candidate Region ◽  
Genetic Adaptation

scholarly journals Genetic adaptation to high altitude in the Ethiopian highlands

2012 ◽  
Vol 13 (1) ◽  
pp. R1 ◽  
Author(s):  
Laura B Scheinfeldt ◽  
Sameer Soi ◽  
Simon Thompson ◽  
Alessia Ranciaro ◽  
Dawit Woldemeskel ◽  
...  
Keyword(s):  
High Altitude ◽  
Genetic Adaptation ◽  
Ethiopian Highlands
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