The Brain-Derived Neurotrophic Factor Val66Met Genotype Does Not Influence the Grey or White Matter Structures Underlying Recognition Memory

2018 ◽  
Author(s):  
Nicole S. McKay ◽  
David. Moreau ◽  
Dion T. Henare ◽  
Ian J. Kirk
Keyword(s):  
White Matter ◽  
Recognition Memory ◽  
Neurotrophic Factor ◽  
Structural Changes ◽  
Memory Performance ◽  
Memory Task ◽  
Brain Derived Neurotrophic Factor ◽  
Hippocampal Volume ◽  
Grey Matter Volume ◽  
Familiarity And Recollection

AbstractA single nucleotide polymorphism (SNP) in the gene coding for brain-derived neurotrophic factor (BDNF) has previously been associated with a reduction in recognition memory performance. While previous findings have highlighted that this SNP contributes to recognition memory, little is known about its influence on subprocesses of recognition, familiarity and recollection. Previous research has reported reduced hippocampal volume and decreased fractional anisotropy in carriers of the Met allele across a range of white matter tracts, including those networks that may support recognition memory. Here, in a sample of 61 healthy young adults, we used a source memory task to measure accuracy on each recognition subprocess, in order to determine whether the Val66Met SNP (rs6265) influences these equally. Additionally, we compared grey matter volume between these groups for structures that underpin familiarity and recollection separately. Finally, we used probabilistic tractography to reconstruct tracts that subserve each of these two recognition systems. Behaviourally, we found group differences on the familiarity measure, but not on recollection. However, we did not find any group difference on grey- or white-matter structures. Together, these results suggest a functional influence of the Val66Met SNP that is independent of coarse structural changes, and nuance previous research highlighting the relationship between BDNF, brain structure, and behaviour.

scholarly journals Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory

2019 ◽  
Vol 30 (3) ◽  
pp. 1001-1015 ◽  
Author(s):  
M Postans ◽  
G D Parker ◽  
H Lundell ◽  
M Ptito ◽  
K Hamandi ◽  
...  
Keyword(s):  
White Matter ◽  
Recognition Memory ◽  
Nonhuman Primates ◽  
Diffusion Tensor ◽  
Memory Performance ◽  
Memory Task ◽  
Interindividual Variation ◽  
White Matter Tract ◽  
Hippocampal Commissure ◽  
Dorsal Hippocampal

Abstract The dorsal hippocampal commissure (DHC) is a white matter tract that provides interhemispheric connections between temporal lobe brain regions. Despite the importance of these regions for learning and memory, there is scant evidence of a role for the DHC in successful memory performance. We used diffusion-weighted magnetic resonance imaging (DW-MRI) and white matter tractography to reconstruct the DHC in both humans (in vivo) and nonhuman primates (ex vivo). Across species, our findings demonstrate a close consistency between the known anatomy and tract reconstructions of the DHC. Anterograde tract-tracer techniques also highlighted the parahippocampal origins of DHC fibers in nonhuman primates. Finally, we derived diffusion tensor MRI metrics from the DHC in a large sample of human subjects to investigate whether interindividual variation in DHC microstructure is predictive of memory performance. The mean diffusivity of the DHC correlated with performance in a standardized recognition memory task, an effect that was not reproduced in a comparison commissure tract—the anterior commissure. These findings highlight a potential role for the DHC in recognition memory, and our tract reconstruction approach has the potential to generate further novel insights into the role of this previously understudied white matter tract in both health and disease.

scholarly journals Similar time course of fast familiarity and slow recollection processes for recognition memory in humans and macaques

2020 ◽  
Author(s):  
Zhemeng Wu ◽  
Martina Kavanova ◽  
Lydia Hickman ◽  
Fiona Lin ◽  
Mark J. Buckley
Keyword(s):  
Recognition Memory ◽  
Animal Studies ◽  
Time Course ◽  
Memory Performance ◽  
Memory Task ◽  
Dual Process ◽  
Operating Characteristics ◽  
Neural Basis ◽  
Similar Time ◽  
Familiarity And Recollection

AbstractAccording to dual-process theory, recognition memory performance draws upon two processes, familiarity and recollection. The relative contribution to recognition memory are commonly distinguished in humans by analyzing receiver-operating-characteristics (ROC) curves; analogous methods are more complex and very rare in animals but fast familiarity and slow recollective-like processes (FF/SR) have been detected in non-human primates (NHPs) based on analyzing recognition error response time profiles. The relative utility of these methods to investigate familiarity and recollection/recollection-like processes across species is uncertain; indeed, even how comparable the FF/SR measures are across humans and NHPs remains unclear. Therefore in this study a broadly similar recognition memory task was exploited in both humans and NHPs to investigate the time course of the two recognition processes. We first show that the FF/SR dissociation exists in this task in human participants and then we demonstrate a similar profile in NHPs which suggests that FF/SR processes are comparable across species. We then verified, using ROC-derived indices for each time-bin in the FF/SR profile, that the ROC and FF/DR measures are related. Hence we argue that the FF/SR approach, procedurally easier in animals, can be used as a decent proxy to investigate these two recognition processes in future animal studies, important given that scant data exists as to the neural basis underlying recollection yet many of the most informative techniques primarily exist in animal models.

scholarly journals A Lack of Correlation between Brain-Derived Neurotrophic Factor Serum Level and Verbal Memory Performance in Healthy Polish Population

2016 ◽  
Vol 10 ◽  
Author(s):  
Monika Wilkosc ◽  
Anita Markowska ◽  
Ludmila Zajac-Lamparska ◽  
Maria Skibinska ◽  
Agnieszka Szalkowska ◽  
...  
Keyword(s):  
Serum Level ◽  
Verbal Memory ◽  
Neurotrophic Factor ◽  
Memory Performance ◽  
Brain Derived Neurotrophic Factor ◽  
Polish Population

Rhythmic Activity and Individual Variability in Recognition Memory: Theta Oscillations Correlate with Performance whereas Alpha Oscillations Correlate with ERPs

2017 ◽  
Vol 29 (1) ◽  
pp. 183-202 ◽  
Author(s):  
Yvonne Y. Chen ◽  
Jeremy B. Caplan
Keyword(s):  
Individual Differences ◽  
Recognition Memory ◽  
Memory Task ◽  
Rhythmic Activity ◽  
Individual Variability ◽  
Theta Oscillations ◽  
Alpha Oscillations ◽  
Alpha Oscillation ◽  
Familiarity And Recollection ◽  
Visual Inattention

During study trials of a recognition memory task, alpha (∼10 Hz) oscillations decrease, and concurrently, theta (4–8 Hz) oscillations increase when later memory is successful versus unsuccessful (subsequent memory effect). Likewise, at test, reduced alpha and increased theta activity are associated with successful memory (retrieval success effect). Here we take an individual-differences approach to test three hypotheses about theta and alpha oscillations in verbal, old/new recognition, measuring the difference in oscillations between hit trials and miss trials. First, we test the hypothesis that theta and alpha oscillations have a moderately mutually exclusive relationship; but no support for this hypothesis was found. Second, we test the hypothesis that theta oscillations explain not only memory effects within participants, but also individual differences. Supporting this prediction, durations of theta (but not alpha) oscillations at study and at test correlated significantly with d′ across participants. Third, we test the hypothesis that theta and alpha oscillations reflect familiarity and recollection processes by comparing oscillation measures to ERPs that are implicated in familiarity and recollection. The alpha-oscillation effects correlated with some ERP measures, but inversely, suggesting that the actions of alpha oscillations on memory processes are distinct from the roles of familiarity- and recollection-linked ERP signals. The theta-oscillation measures, despite differentiating hits from misses, did not correlate with any ERP measure; thus, theta oscillations may reflect elaborative processes not tapped by recollection-related ERPs. Our findings are consistent with alpha oscillations reflecting visual inattention, which can modulate memory, and with theta oscillations supporting recognition memory in ways that complement the most commonly studied ERPs.

scholarly journals Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63535 ◽  
Author(s):  
Catarina Rendeiro ◽  
David Vauzour ◽  
Marcus Rattray ◽  
Pierre Waffo-Téguo ◽  
Jean Michel Mérillon ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Neurotrophic Factor ◽  
Memory Performance ◽  
Brain Derived Neurotrophic Factor
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