scholarly journals Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish

2019 ◽  
Author(s):  
Emanuele Gioacchino ◽  
Cansu Koyunlar ◽  
Hans de Looper ◽  
Madelon de Jong ◽  
Tomasz Dobrzycki ◽  
...  
Keyword(s):  
Single Cell ◽  
Transcriptome Analysis ◽  
Progenitor Cell ◽  
Adult Zebrafish ◽  
Hematopoietic Stem ◽  
Lineage Differentiation ◽  
Hematopoietic Lineage ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome ◽  
Monocytic Lineage

AbstractHematopoietic stem cells (HSCs) are tightly controlled to keep a balance between myeloid and lymphoid cell differentiation. Gata2 is a pivotal hematopoietic transcription factor required for HSC generation and maintenance. We generated a zebrafish mutant for the mammalianGata2orthologue,gata2b. We found that in adult zebrafish,gata2bis required for both neutrophilic- and monocytic lineage differentiation. Single cell transcriptome analysis revealed that the myeloid defect present in Gata2b deficient zebrafish arise in the most immature hematopoietic stem and progenitor cell (HSPC) compartment and that this population is instead committed towards the lymphoid and erythroid lineage. Taken together, we find that Gata2b is vital for the fate choice between the myeloid and lymphoid lineages.

scholarly journals Single cell transcriptome analysis upon MCF-7 breast cancer

2010 ◽  
Vol 11 (Suppl 1) ◽  
pp. P8 ◽  
Author(s):  
Yih-Shien Chiang ◽  
Lock Seng ◽  
You-Yu Lin ◽  
Shih-Hao Chen ◽  
Yu-Chang Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Cell ◽  
Transcriptome Analysis ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome ◽  
Mcf 7

scholarly journals Single-Cell Transcriptome Analysis Reveals Mesenchymal Stem Cells in Cavernous Hemangioma

2021 ◽  
Author(s):  
Fulong Ji ◽  
Yong Liu ◽  
Jinsong Shi ◽  
Chunxiang Liu ◽  
Siqi Fu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Single Cell ◽  
Cavernous Hemangioma ◽  
Transcriptome Analysis ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-cell transcriptome analysis of Physcomitrella leaf cells during reprogramming using microcapillary manipulation

2019 ◽  
Vol 47 (9) ◽  
pp. 4539-4553 ◽  
Author(s):  
Minoru Kubo ◽  
Tomoaki Nishiyama ◽  
Yosuke Tamada ◽  
Ryosuke Sano ◽  
Masaki Ishikawa ◽  
...  
Keyword(s):  
Single Cell ◽  
Transcriptome Analysis ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer

Cell Reports ◽  
2019 ◽  
Vol 27 (9) ◽  
pp. 2798 ◽  
Author(s):  
Detu Zhu ◽  
Zuxianglan Zhao ◽  
Guimei Cui ◽  
Shiehong Chang ◽  
Lingling Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Cell ◽  
Transcriptome Analysis ◽  
Estrogen Signaling ◽  
Purine Synthesis ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes

2020 ◽  
Vol 28 (7) ◽  
pp. 1658-1672 ◽  
Author(s):  
Junyi Hu ◽  
Zhaohui Chen ◽  
Lin Bao ◽  
Lijie Zhou ◽  
Yaxin Hou ◽  
...  
Keyword(s):  
Single Cell ◽  
Clinical Outcomes ◽  
Transcriptome Analysis ◽  
Intratumoral Heterogeneity ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

2019 ◽  
Vol 25 (5) ◽  
pp. 697-712.e6 ◽  
Author(s):  
Lizhi Leng ◽  
Jiya Sun ◽  
Jinrong Huang ◽  
Fei Gong ◽  
Ling Yang ◽  
...  
Keyword(s):  
Single Cell ◽  
Transcriptome Analysis ◽  
Preimplantation Development ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome
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