scholarly journals Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Steffen Grosser ◽  
Jürgen Lippoldt ◽  
Linda Oswald ◽  
Matthias Merkel ◽  
Daniel M. Sussman ◽  
...  
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2007 ◽  
Vol 71 (3) ◽  
pp. 405-407 ◽  
Author(s):  
Yu. N. Koblik ◽  
V. P. Pikul’ ◽  
B. S. Yuldashev ◽  
P. D. Ioannou ◽  
E. S. Flitsiyan

2019 ◽  
Vol 623 ◽  
pp. A120 ◽  
Author(s):  
D. Marshall ◽  
L. Rezac ◽  
P. Hartogh ◽  
Y. Zhao ◽  
N. Attree

Aims. We investigate the influence of three basic factors on water production rate as a function of heliocentric distance: nucleus shape, the spin axis orientation, and the distribution of activity on a comet’s surface. Methods. We used a basic water sublimation model driven by solar insolation to derive total production rates for different nuclei shapes and spin axis orientations using the orbital parameters of 67P/Churyumov-Gerasimenko. We used known shape models derived from prior missions to the Jupiter Family and short period comets. The slopes of production rates versus heliocentric distance were calculated for the different model setups. Results. The standard (homogeneous) outgassing model confirms the well-known result regarding the heliocentric dependence of water production rate that remains invariant for different nuclei shapes as long as the rotation axis is perpendicular to the orbital plane. When the rotation axis is not perpendicular, the nucleus shape becomes a critically important factor in determining the water production curves as the illuminated cross section of the nucleus changes with heliocentric distance. Shape and obliquity can produce changes in the illuminated cross section of up to 50% over an orbit. In addition, different spin axis orientations for a given shape can dramatically alter the pre- and post-perihelion production curves, as do assumptions about the activity distribution on the surface. If, however, the illuminated cross section of the nucleus is invariant, then the dependence on the above parameters is weak, as demonstrated here with the 67P/Churyumov-Gerasimenko shape. The comets Hartley 2 and Wild 2 are shown to yield significantly different production curve shapes for the same orbit and orientation as 67P/CG, varying by as much as a factor of three as a result of only changing the nucleus shape. Finally, we show that varying just three basic parameters, shape, spin axis orientation, and active spots distribution on the surface can lead to arbitrary deviations from the expected inverse square law dependence of water production rates near 1 au. Conclusions. With the results obtained, we cannot avoid the conclusion that, without prior knowledge of basic parameters (shape, spin axis orientation, activity locations), it is difficult to reveal the nature of cometary outgassing from the heliocentric water production rates. Similarly, the inter-comparison of water production curves of two such comets may not be meaningful.


1978 ◽  
Vol 9 (7) ◽  
pp. 1016-1017 ◽  
Author(s):  
Kwai S. Chan ◽  
J. K. Lee ◽  
G. J. Shiflet ◽  
K. C. Russell ◽  
H. I. Aaronson

2021 ◽  
Author(s):  
Rana Amini ◽  
Raimund Schlüßler ◽  
Stephanie Möllmert ◽  
Archit Bhatnagar ◽  
Jochen Guck ◽  
...  

As neurons are often born at positions different than where they ultimately function, neuronal migration is key to ensure successful nervous system development. Radial migration during which neurons featuring unipolar and bipolar morphology, employ pre-existing processes or underlying cells for directional guidance, is the most well explored neuronal migration mode. However, how neurons that display multipolar morphology, without such processes, move through highly crowded tissue environments towards their final positions remains elusive. To understand this, we here investigated multipolar migration of horizontal cells in the zebrafish retina. We found that horizontal cells tailor their movements to the environmental spatial constraints of the crowded retina, by featuring several characteristics of amoeboid migration. These include cell and nucleus shape changes, and persistent rearward polarization of stable F-actin, which enable horizontal cells to successfully move through the crowded retina. Interference with the organization of the developing retina by changing nuclear properties or overall tissue architecture, hampers efficient horizontal cell migration and layer formation. Thus, cell-tissue interplay is crucial for efficient migration of horizontal cells in the retina. In view of high proportion of multipolar neurons, the here uncovered ameboid-like neuronal migration mode might also be crucial in other areas of the developing brain.


2019 ◽  
Vol 5 (8) ◽  
pp. eaav0318 ◽  
Author(s):  
Clement M. Lee ◽  
Ken Aizawa ◽  
Joshua Jiang ◽  
Sam K. P. Kung ◽  
Rinku Jain

JLP belongs to the JIP family whose members serve as scaffolding proteins that link motor proteins and their cargo for intracellular transport. Although JLP is mainly cytoplasmic, it accumulates as a focus in the perinuclear region when stimulated by extracellular stimuli. Focus formation, which changes the nucleus shape and concentrates the nuclear pores, depends on p38MAPK activation and the dynein retrograde motor protein complex. Extracellular stimuli trigger the tethering of PLK1 to the centrosome by JLP, leading to centrosome maturation and microtubule array formation. The centrosome localization domain of JLP is important for the binding of the centrosome and the formation of the JLP focus and the microtubule array. Furthermore, the formation of the JLP focus and the microtubule array is interdependent and important for the transport of NF-κB p65 to the nucleus and its unloading therein. In conclusion, JLP exhibits multiple functions in the nuclear translocation of NF-κB p65.


2007 ◽  
Vol 39 (9) ◽  
pp. 2846-2849 ◽  
Author(s):  
J. Nozynski ◽  
M. Zakliczynski ◽  
E. Zembala-Nozynska ◽  
D. Konecka-Mrowka ◽  
R. Przybylski ◽  
...  
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