scholarly journals Hydrogen-bonding synthons in lamotrigine salts: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin-2-ium 2-[(2-carboxyphenyl)disulfanyl]benzoate in its monohydrate and anhydrous forms

2016 ◽  
Vol 72 (11) ◽  
pp. 910-916 ◽  
Author(s):  
Eleonora Freire ◽  
Griselda Polla ◽  
Ricardo Baggio

Lamotrigine is a drug used in the treatment of epilepsy and related convulsive diseases. The drug in its free form is rather inadequate for pharmacological use due to poor absorption by the patient, which limits its bioavailability. On the other hand, the lamotrigine molecule is an excellent hydrogen-bonding agent and this has been exploited intensively in the search for better formulations. The formulation presently commercialized (under the brand name Lamictal) is rather complex and includes a number of anions in addition to the active pharmaceutical ingredient (API). The title salts of lamotrigine, namely 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin-2-ium 2-[(2-carboxyphenyl)disulfanyl]benzoate monohydrate, C9H8Cl2N5+·C14H9O4S2−·H2O, (I), and the anhydrate, C9H8Cl2N5+·C14H9O4S2−, (II), contain a lamotriginium cation (L), a hydrogen dithiodibenzoate monoanion (D) and, in the case of (I), a disordered solvent water molecule. BothLandDpresent their usual configurations severely twisted around their central C—C and S—S bonds, respectively. The supramolecular structure generated by the many available donor and acceptor sites is characterized by a planar antisymmetric motif of the formD–L–L–D,i.e.the structural building block. Although this characteristic motif is extremely similar in both structures, its conformation involves different donors and acceptors in itsR22(8) centralL–Lhomosynthon. The lateralR22(8)D–Lheterosynthons are, on the other hand, identical. These substructures are further connected by strong hydrogen bonds into broad two-dimensional structures, in turn weakly linked to each other. Even if the homo- and heterosynthons in (I) and (II) are rather frequent in lamotrigine structural chemistry, the composite tetrameric synthon appears to be much less common. The occurrence of these motifs among lamotrigine salts and cocrystals is analyzed.

2008 ◽  
Vol 29 (2) ◽  
pp. 507-525
Author(s):  
J H Van Wyk

“Is Christ divided?” Reflections on the theological justification of church disunity and church schismIn this article the author investigates the question whether a church schism could ever be justified. He considers on the one hand the Biblical message on church unity and on the other hand the many justifications of church disunity (schism). He concludes that most of these justifications are unacceptable rasionalisations and that Post-Reformation theology distanced itself far away from Biblical ecclesiology in this regard.


2021 ◽  
Author(s):  
◽  
Samuele Tonello

<p>This thesis in divided in two main parts. First, I develop the claim that current democracies are unable to properly defend what I deem the pivotal feature to evaluate the quality of a political system - namely the people’s liberty - due to what I call a twofold democratic dilemma. On the one hand, common citizens are affected by biases that compromise their ability to successfully maintain forms of self-government. On the other hand, even representative forms of democracy that limit to a certain degree the people’s power are threatened by an oligarchic power. That is, oligarchs are using their wealth power to sway governments towards pursuing oligarchic interests rather than common ones, thus hindering the people’s liberty. For this reason, I argue that we ought to rely on Pettit’s view of liberty as non-domination to resolve the democratic dilemma. The thesis conceives these two threats as two forms of domination that must be avoided and focuses on adding a supplementary editorial and contestatory dimension of democracy to the classical participatory one. Republicanism could offer a solution to both sides of the dilemma. On the one hand, citizens’ political task would be more compatible with the people’s biases, since citizens would limit their participation to control that government’s policies do not entail oligarchic domination. On the other hand, framing liberty as a battle between dominating masters and dominated slaves, republicanism could offer the many the institutional means to counteract elites’ political domination. In this way, I conclude the first part of the thesis, but this opens the gates to the main question of the thesis, namely to how we should structure this contestatory democracy. The problem is that whereas republican scholars agree on the importance of setting freedom as non-domination at the basis of our political systems, there is no such agreement on the best way to institutionally enhance the republican ideal. I analyse this debate, maintaining that while Pettitt’s ideal is the view to pursue, we should reject his editorial solution because small committees of experts are likely to increase oligarchic domination rather than to protect the people’s liberty. Rejecting Pettit’s model does not yet imply refusing any editorial model, since I argue that critical scholars mistakenly identify the editorial component of democracy with Pettit’s answer only. In this way, they neglect alternative solutions to Pettit’s, such as Bellamy’s and McCormick’s. Having explained that Bellamy’s solution does not resolve the democratic dilemma, since this scholar rejects editorial bodies, I argue that McCormick’s “Machiavellian Democracy” framed on a divided conception of the populace offers instead the solution I am looking for. Institutionally recognizing the social differences among the populace, we could create modern bodies similar to the Roman “Tribune of the Plebs” to offer the weaker part of the population a class-specific institution to use as defence from oligarchic domination. The problem is how to implement a modern “Tribune of the plebs” making sure that these bodies are effective but popular in character at the same time. I thus explain how modern editorial tribunates could work in practice, drawing from McCormick’s “thought experiment”. I agree with most of McCormick’s ideas – lottery selection, wealth threshold exclusion, large size tribunates, etc. - but I suggest that we must review some of his suggestions with features more concerned with improving the people’s knowledge – specialization, education selection, etc. Hence, I conclude the thesis describing my thought experiment of a system of Specialized Ministerial Tribunates. In this way, I argue that we could better resolve the democratic dilemma. On the one hand, tribunates’ editorship would be more specific and would not require members of the tribunate to analyse the operation of governments on a too broad spectrum, thus reducing the problems of the people’s biases. On the other hand, tribunates’ operation could be primarily connected to detecting oligarchic features in the policies enacted by single ministries, thus challenging more precisely any oligarchic influence over governments. In sum, I argue that an editorial dimension could produce significant improvements to the people’s liberty. Thanks to a modern “Tribune of the plebs”, citizens could participate more meaningfully in politics, while taming more efficiently the influence oligarchs have on how modern societies are politically directed.</p>


2021 ◽  
Author(s):  
◽  
Samuele Tonello

<p>This thesis in divided in two main parts. First, I develop the claim that current democracies are unable to properly defend what I deem the pivotal feature to evaluate the quality of a political system - namely the people’s liberty - due to what I call a twofold democratic dilemma. On the one hand, common citizens are affected by biases that compromise their ability to successfully maintain forms of self-government. On the other hand, even representative forms of democracy that limit to a certain degree the people’s power are threatened by an oligarchic power. That is, oligarchs are using their wealth power to sway governments towards pursuing oligarchic interests rather than common ones, thus hindering the people’s liberty. For this reason, I argue that we ought to rely on Pettit’s view of liberty as non-domination to resolve the democratic dilemma. The thesis conceives these two threats as two forms of domination that must be avoided and focuses on adding a supplementary editorial and contestatory dimension of democracy to the classical participatory one. Republicanism could offer a solution to both sides of the dilemma. On the one hand, citizens’ political task would be more compatible with the people’s biases, since citizens would limit their participation to control that government’s policies do not entail oligarchic domination. On the other hand, framing liberty as a battle between dominating masters and dominated slaves, republicanism could offer the many the institutional means to counteract elites’ political domination. In this way, I conclude the first part of the thesis, but this opens the gates to the main question of the thesis, namely to how we should structure this contestatory democracy. The problem is that whereas republican scholars agree on the importance of setting freedom as non-domination at the basis of our political systems, there is no such agreement on the best way to institutionally enhance the republican ideal. I analyse this debate, maintaining that while Pettitt’s ideal is the view to pursue, we should reject his editorial solution because small committees of experts are likely to increase oligarchic domination rather than to protect the people’s liberty. Rejecting Pettit’s model does not yet imply refusing any editorial model, since I argue that critical scholars mistakenly identify the editorial component of democracy with Pettit’s answer only. In this way, they neglect alternative solutions to Pettit’s, such as Bellamy’s and McCormick’s. Having explained that Bellamy’s solution does not resolve the democratic dilemma, since this scholar rejects editorial bodies, I argue that McCormick’s “Machiavellian Democracy” framed on a divided conception of the populace offers instead the solution I am looking for. Institutionally recognizing the social differences among the populace, we could create modern bodies similar to the Roman “Tribune of the Plebs” to offer the weaker part of the population a class-specific institution to use as defence from oligarchic domination. The problem is how to implement a modern “Tribune of the plebs” making sure that these bodies are effective but popular in character at the same time. I thus explain how modern editorial tribunates could work in practice, drawing from McCormick’s “thought experiment”. I agree with most of McCormick’s ideas – lottery selection, wealth threshold exclusion, large size tribunates, etc. - but I suggest that we must review some of his suggestions with features more concerned with improving the people’s knowledge – specialization, education selection, etc. Hence, I conclude the thesis describing my thought experiment of a system of Specialized Ministerial Tribunates. In this way, I argue that we could better resolve the democratic dilemma. On the one hand, tribunates’ editorship would be more specific and would not require members of the tribunate to analyse the operation of governments on a too broad spectrum, thus reducing the problems of the people’s biases. On the other hand, tribunates’ operation could be primarily connected to detecting oligarchic features in the policies enacted by single ministries, thus challenging more precisely any oligarchic influence over governments. In sum, I argue that an editorial dimension could produce significant improvements to the people’s liberty. Thanks to a modern “Tribune of the plebs”, citizens could participate more meaningfully in politics, while taming more efficiently the influence oligarchs have on how modern societies are politically directed.</p>


2011 ◽  
Vol 37 (9) ◽  
pp. 999-1010 ◽  
Author(s):  
Ignaas Devisch

French philosopher Jean-Luc Nancy is acting uneasily when it comes to contemporary politics. There is a sort of agitation in his work in relation to this question. At several places we read an appeal to deal thoroughly with this question and ‘ qu’il y a un travail à faire’, that there is still work to do. From the beginning of the 1980s with the ‘Centre de Recherches Philosophiques sur le Politique’ and the two books resulting out of that, until the many, rather short texts he published on this topic during the last years of the century, the question of politics crosses very clearly Nancy’s work. He not only fulminates against the contemporary philosophical ‘content’ with democracy. Instead of defending a political regime, he wants to think the form of politics in the most critical and sceptical way. To Nancy, the worst thing we can do in thinking contemporary politics, is taking it for granted that we know what politics is about today, given the evidence of the global democracy. So to him, we almost have to be at unease when it comes to politics. On the other hand, in thinking contemporary democracy, the work of Claude Lefort is undeniably the main reference. Long before the collapse of the Berlin Wall and the upsurge of an all-too-easy anti-Marxism, Lefort articulated in a nuanced way the formal differences between totalitarianism and democracy. According to Lefort, the specific ‘form’ of democracy is that it never becomes an accomplished and fulfilled form as such. In a certain sense, the only ‘form’ of democracy is formlessness, a form without form. In a democracy, the place of power becomes literally ‘ infigurable’ as Lefort says. Democracy stands for formlessness or the relation to a void. Nancy objects so to say against a ‘Leformal’ conception of democracy – the empty place, the formless, the ‘ infigurable’ or ‘ sans figure’, the ever yet to come. … This conception of democracy would still be caught in the infinite metaphysical, dialectical horizon of immanentism, while it pretends to have already left that horizon behind it, presenting itself as the finite alternative to the infinite totalitarian politics. Democracy as formlessness is indeed no longer based on a metaphysical Idea, Figure, or Truth. We want to clear up the philosophical sky of Nancy’s remarks by confronting them with some thoughts of Lefort.


1969 ◽  
Vol 62 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Ralph Walter Klein

In a recent study of the Greek text of 1 Esdras we argued that it frequently reflected an old, often nonexpanded Semitic Vorlage despite the many corruptions and secondary expansions peculiar to the “apocryphal” text. Esdras B [hereafter: G], on the other hand, was also found to differ from the received Hebrew text, but its variants were small enough that its underlying text-type could be called Proto-Massoretic. This analysis conflicts with that of Bernhard Walde, Wilhelm Rudolph, and others, who would assign the same geographical and chronological horizons and nearly identical Vorlagen to 1 Esdras and G. We shall test our interpretation, therefore, by studying the differences in the Hebrew texts of Ezra 2 and Nehemiah 7 on the basis of the translation of Ezra 2 in 1 Esdras 5. Although the latter has many omissions and doublets —in fact, it is in relatively poor shape —not enough attention has been paid to its alternation between Ezra-type and Nehemiah-type texts.


Author(s):  
Ivica Cvrtila ◽  
Vladimir Stilinović

The crystal structures of two polymorphs of a phenazine hexacyanoferrate(II) salt/cocrystal, with the formula (Hphen)3[H2Fe(CN)6][H3Fe(CN)6]·2(phen)·2H2O, are reported. The polymorphs are comprised of (Hphen)2[H2Fe(CN)6] trimers and (Hphen)[(phen)2(H2O)2][H3Fe(CN)6] hexamers connected into two-dimensional (2D) hydrogen-bonded networks through strong hydrogen bonds between the [H2Fe(CN)6]2− and [H3Fe(CN)6]− anions. The layers are further connected by hydrogen bonds, as well as through π–π stacking of phenazine moieties. Aside from the identical 2D hydrogen-bonded networks, the two polymorphs share phenazine stacks comprising both protonated and neutral phenazine molecules. On the other hand, the polymorphs differ in the conformation, placement and orientation of the hydrogen-bonded trimers and hexamers within the hydrogen-bonded networks, which leads to different packing of the hydrogen-bonded layers, as well as to different hydrogen bonding between the layers. Thus, aside from an exceptional number of symmetry-independent units (nine in total), these two polymorphs show how robust structural motifs, such as charge-assisted hydrogen bonding or π-stacking, allow for different arrangements of the supramolecular units, resulting in polymorphism.


PEDIATRICS ◽  
1975 ◽  
Vol 56 (2) ◽  
pp. 332-334
Author(s):  
Anna Freud

I take the honour which is being bestowed on me today as another welcome sign that the estrangement between pediatrics and child psychology is nearing its end and the partners on either side are contemplating a serious engagement, if not the propect of future marriage with each other. There are many other indications which point in the same direction. I only need to mention the fact that there are now places of learning where the head of the department combines in his own person training and functions in physical as well as mental child care; or that pediatricians are considered essential consultants in child guidance clinics, or that some pediatricians participate in the discussions of interdisciplinary hospital groups, or that, occasionally, child psychiatrists and even child analysts are called to the bedside of hospitalized children for consultation. There is no reason, on the other hand, to feel entirely optimistic and to relax efforts towards further re-alignment. Cooperative attitudes between the two disciplines can also be regarded still as few and far between and, above all, confined to selected medical specialities and a small number of selected, furthest advanced, and enlightened centers. There exist still many children's wards where bodily care is so paramount that any thought about the child's mental concerns is excluded as intrusive and disruptive. There are, above all, the many surgeons who, rightly or wrongly, feel that their difficult task cannot be accomplished except by determined and exclusive concentration on the defective body part which needs repair.


2012 ◽  
Vol 27 (4) ◽  
pp. 231-237 ◽  
Author(s):  
KH Woldendorp ◽  
W van Gils

There are many musicians with acquired limitations in making music, and there are many people with a disability who would like to play a music instrument in a modified way. There is discouragingly little information about this topic in literature. This article gives an overview of “making music in a modified way.” It focuses on the possibilities for musicians with one-handed functionality to overcome problems with regards to their physical condition, insufficient muscle strength, or missing parts of the upper extremity. Five categories of possibilities for the functional one-handed musicians are described: 1) one-hand reconstructed instruments, 2) one-hand compositions, 3) adaptations of the instrument for the other hand, 4) prostheses to make it possible to play with both hands/arms, and 5) other techniques which enable the use of the leg(s). The solutions described make clear that playing music in an adaptive way requires an interdisciplinary approach. The purpose of this article is to inform, and to inspire, the healthcare professional about the many possibilities for functional one-handed musicians.


Author(s):  
Celene Ibrahim

This chapter discusses Qur’anic concepts related to sex and sexuality and considers how sex, as a feature of embodiment and as an act of intimacy, factors into Qur’anic narratives. It delineates concepts such as “female,” “woman,” and “wife,” and gives attention to Qur’anic notions of virginity and beauty. The chapter points out the many provocative juxtapositions between female figures, the situations that they navigate, and the moral valences of their actions and intentions. It demonstrates how the issue of illicit sex is a major human dilemma in the Qur’anic worldview, both for the chaste who are unjustly accused of illicit sex and for immoral people who create havoc for themselves and others through their profligacy and moral bankruptcy. On the other hand, the Qur’an does not emphasize the trope of the seductress; of the dozens of female figures mentioned in the Qur’an, only one plays this role, and even she can be directly contrasted to women in similar, potentially compromising situations who take the morally sound course of action. Qur’anic terminology for paradisal beings and the possibility of sex in paradise is also discussed.


Author(s):  
Reinhard Bork ◽  
Renato Mangano

This chapter deals with European cross-border issues concerning groups of companies. This chapter, after outlining the difficulties encountered throughout the world in defining and regulating the group, focuses on the specific policy choices endorsed by the EIR, which clearly does not lay down any form of substantive consolidation. Instead, the EIR, on the one hand, seems to permit the ‘one group—one COMI’ rule, even to a limited extent, and, on the other hand, provides for two different regulatory devices of procedural consolidation, one based on the duties of ‘cooperation and communication’ and the other on a system of ‘coordination’ to be set up between the many proceedings affecting companies belonging to the same group.


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