Prior knowledge based fast imaging for scanning ion conductance microscopy

2013 ◽  
Author(s):  
Peng Li ◽  
Changlin Zhang ◽  
Lianqing Liu ◽  
Yuechao Wang ◽  
Ning Xi ◽  
...  
Keyword(s):  
Prior Knowledge ◽  
Fast Imaging ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy ◽  
Knowledge Based

A fast imaging method of scanning ion conductance microscopy

Micron ◽  
2018 ◽  
Vol 114 ◽  
pp. 8-13 ◽  
Author(s):  
Gongxin Li ◽  
Xing Fang
Keyword(s):  
Fast Imaging ◽  
Imaging Method ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy

scholarly journals Cell stiffness and ROS level alterations in living neurons mediated by β-amyloid oligomers measured by scanning ion-conductance microscopy.

2021 ◽  
Vol 27 (S1) ◽  
pp. 500-502
Author(s):  
Oleg Suchalko ◽  
Roman Timoshenko ◽  
Alexander Vaneev ◽  
Vasilii Kolmogorov ◽  
Nikita Savin ◽  
...  
Keyword(s):  
Cell Stiffness ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy ◽  
Amyloid Oligomers ◽  
Β Amyloid ◽  
Living Neurons

scholarly journals Nanoscale Cell Membrane Fluctuations Measured by Scanning Ion Conductance Microscopy

2013 ◽  
Vol 104 (2) ◽  
pp. 317a
Author(s):  
Yusuke Mizutani ◽  
Zen Ishikura ◽  
Myung-Hoon Choi ◽  
Sang-Joon Cho ◽  
Takaharu Okajima
Keyword(s):  
Cell Membrane ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy ◽  
Membrane Fluctuations

scholarly journals Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization

2017 ◽  
Vol 114 (9) ◽  
pp. 2395-2400 ◽  
Author(s):  
Umesh Vivekananda ◽  
Pavel Novak ◽  
Oscar D. Bello ◽  
Yuri E. Korchev ◽  
Shyam S. Krishnakumar ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Calcium Influx ◽  
Digital Transmission ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy ◽  
Spike Shape ◽  
Presynaptic Spike ◽  
Synaptic Boutons ◽  
Episodic Ataxia Type

Although action potentials propagate along axons in an all-or-none manner, subthreshold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic boutons. An important mechanism underlying analog–digital modulation is depolarization-mediated inactivation of presynaptic Kv1-family potassium channels, leading to action potential broadening and increased calcium influx. Previous studies have relied heavily on recordings from blebs formed after axon transection, which may exaggerate the passive propagation of somatic depolarization. We recorded instead from small boutons supplied by intact axons identified with scanning ion conductance microscopy in primary hippocampal cultures and asked how distinct potassium channels interact in determining the basal spike width and its modulation by subthreshold somatic depolarization. Pharmacological or genetic deletion of Kv1.1 broadened presynaptic spikes without preventing further prolongation by brief depolarizing somatic prepulses. A heterozygous mouse model of episodic ataxia type 1 harboring a dominant Kv1.1 mutation had a similar broadening effect on basal spike shape as deletion of Kv1.1; however, spike modulation by somatic prepulses was abolished. These results argue that the Kv1.1 subunit is not necessary for subthreshold modulation of spike width. However, a disease-associated mutant subunit prevents the interplay of analog and digital transmission, possibly by disrupting the normal stoichiometry of presynaptic potassium channels.

Scanning Ion Conductance Microscopy for High-Resolution Topography of Soft Samples Including Live Cells

2011 ◽  
Vol 17 (S2) ◽  
pp. 236-237
Author(s):  
G De Filippi ◽  
C Moore
Keyword(s):  
High Resolution ◽  
Live Cells ◽  
Ion Conductance ◽  
Scanning Ion Conductance Microscopy ◽  
Soft Samples

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.

scholarly journals Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA

2017 ◽  
Vol 221 ◽  
pp. 427-436 ◽  
Author(s):  
Anthony L. Schroeder ◽  
Dalma Martinović-Weigelt ◽  
Gerald T. Ankley ◽  
Kathy E. Lee ◽  
Natalia Garcia-Reyero ◽  
...  
Keyword(s):  
Prior Knowledge ◽  
River Basin ◽  
Biological Effects ◽  
Knowledge Based

A noise reduction method for semi-supervised community detection based on harmonic function

2018 ◽  
Vol 32 (14) ◽  
pp. 1850166 ◽  
Author(s):  
Lilin Fan ◽  
Kaiyuan Song ◽  
Dong Liu
Keyword(s):  
Harmonic Function ◽  
Prior Knowledge ◽  
Community Detection ◽  
Detection Methods ◽  
Detection Process ◽  
Knowledge Based ◽  
Detection Approach ◽  
Series Of Experiments ◽  
Novel Strategy ◽  
The Impact

Semi-supervised community detection is an important research topic in the field of complex network, which incorporates prior knowledge and topology to guide the community detection process. However, most of the previous work ignores the impact of the noise from prior knowledge during the community detection process. This paper proposes a novel strategy to identify and remove the noise from prior knowledge based on harmonic function, so as to make use of prior knowledge more efficiently. Finally, this strategy is applied to three state-of-the-art semi-supervised community detection methods. A series of experiments on both real and artificial networks demonstrate that the accuracy of semi-supervised community detection approach can be further improved.

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