Twine Stack: A Hybrid Mechanism Achieving Less Cost for Return Address Protection

2021 ◽  
Author(s):  
Qizhen Xu ◽  
Liwei Chen ◽  
Gang Shi
Keyword(s):  
Hybrid Mechanism ◽  
Return Address

Schistosomal Sulfotransferase Interaction with Oxamniquine Involves Hybrid Mechanism of Induced-fit and Conformational Selection

2020 ◽  
Vol 16 (4) ◽  
pp. 451-459 ◽  
Author(s):  
Fortunatus C. Ezebuo ◽  
Ikemefuna C. Uzochukwu
Keyword(s):  
Molecular Dynamics ◽  
Amino Acid ◽  
Binding Energy ◽  
Binding Site ◽  
Conformational Dynamics ◽  
Side Chain ◽  
Amino Acid Residues ◽  
Conformational Selection ◽  
Hybrid Mechanism ◽  
Dynamics Simulations

Background: Sulfotransferase family comprises key enzymes involved in drug metabolism. Oxamniquine is a pro-drug converted into its active form by schistosomal sulfotransferase. The conformational dynamics of side-chain amino acid residues at the binding site of schistosomal sulfotransferase towards activation of oxamniquine has not received attention. Objective: The study investigated the conformational dynamics of binding site residues in free and oxamniquine bound schistosomal sulfotransferase systems and their contribution to the mechanism of oxamniquine activation by schistosomal sulfotransferase using molecular dynamics simulations and binding energy calculations. Methods: Schistosomal sulfotransferase was obtained from Protein Data Bank and both the free and oxamniquine bound forms were subjected to molecular dynamics simulations using GROMACS-4.5.5 after modeling it’s missing amino acid residues with SWISS-MODEL. Amino acid residues at its binding site for oxamniquine was determined and used for Principal Component Analysis and calculations of side-chain dihedrals. In addition, binding energy of the oxamniquine bound system was calculated using g_MMPBSA. Results: The results showed that binding site amino acid residues in free and oxamniquine bound sulfotransferase sampled different conformational space involving several rotameric states. Importantly, Phe45, Ile145 and Leu241 generated newly induced conformations, whereas Phe41 exhibited shift in equilibrium of its conformational distribution. In addition, the result showed binding energy of -130.091 ± 8.800 KJ/mol and Phe45 contributed -9.8576 KJ/mol. Conclusion: The results showed that schistosomal sulfotransferase binds oxamniquine by relying on hybrid mechanism of induced fit and conformational selection models. The findings offer new insight into sulfotransferase engineering and design of new drugs that target sulfotransferase.

Hybrid mechanism for medical data classification

2021 ◽  
Vol 19 (3/4) ◽  
pp. 243
Author(s):  
Ahelam Mainoddin Tikotikar ◽  
Mallikarjun M. Kodabagi
Keyword(s):  
Data Classification ◽  
Medical Data ◽  
Hybrid Mechanism ◽  
Medical Data Classification

Improved influential nodes identification in complex networks

2021 ◽  
pp. 1-9
Author(s):  
Shi Dong ◽  
Wengang Zhou
Keyword(s):  
Theoretical Analysis ◽  
Complex Networks ◽  
Network Structure ◽  
Information Entropy ◽  
Network System ◽  
Weighted Degree ◽  
Identification Methods ◽  
Hybrid Mechanism ◽  
Influential Nodes ◽  
Influential Node

Influential node identification plays an important role in optimizing network structure. Many measures and identification methods are proposed for this purpose. However, the current network system is more complex, the existing methods are difficult to deal with these networks. In this paper, several basic measures are introduced and discussed and we propose an improved influential nodes identification method that adopts the hybrid mechanism of information entropy and weighted degree of edge to improve the accuracy of identification (Hm-shell). Our proposed method is evaluated by comparing with nine algorithms in nine datasets. Theoretical analysis and experimental results on real datasets show that our method outperforms other methods on performance.

Type Synthesis of a 1T Symmetric Coupling Mechanism with the Method of Separation and Merger

2014 ◽  
Vol 635-637 ◽  
pp. 1290-1293
Author(s):  
Shou Li Zhang ◽  
Jing Fang Liu ◽  
Yue Qing Yu
Keyword(s):  
Linear Combination ◽  
Parallel Mechanism ◽  
Creative Design ◽  
Coupling Mechanism ◽  
Type Synthesis ◽  
Structural Synthesis ◽  
Hybrid Mechanism ◽  
Coupled Structures ◽  
Coupling Mechanisms

The structural synthesis is the primary and the most important issue in the process of mechanism creative design. In the paper, Firstly, select a 1T symmetric parallel mechanism, and the constraint and mobility of the branches can be analyzed. With the method of linear combination of the screws, the new branches are constructed. Then, using the measure of separation and merger, parts of the limbs of the parallel mechanism can be replaced by equivalent coupled structures, so corresponding symmetric coupling mechanisms with equal mobility are synthesized. Finally, solving the constraint screws of the branch of the coupling mechanism, in order to prove the hybrid mechanism is full-cycle or not.

scholarly journals Multi-Type Resource Allocation with Partial Preferences

2020 ◽  
Vol 34 (02) ◽  
pp. 2260-2267
Author(s):  
Haibin Wang ◽  
Sujoy Sikdar ◽  
Xiaoxi Guo ◽  
Lirong Xia ◽  
Yongzhi Cao ◽  
...  
Keyword(s):  
Resource Allocation ◽  
Partial Order ◽  
Impossibility Result ◽  
Equal Treatment ◽  
Ex Post ◽  
Hybrid Mechanism ◽  
Random Priority ◽  
Unrestricted Domain ◽  
Main Message ◽  
Equal Treatment Of Equals

We propose multi-type probabilistic serial (MPS) and multi-type random priority (MRP) as extensions of the well-known PS and RP mechanisms to the multi-type resource allocation problems (MTRAs) with partial preferences. In our setting, there are multiple types of divisible items, and a group of agents who have partial order preferences over bundles consisting of one item of each type. We show that for the unrestricted domain of partial order preferences, no mechanism satisfies both sd-efficiency and sd-envy-freeness. Notwithstanding this impossibility result, our main message is positive: When agents' preferences are represented by acyclic CP-nets, MPS satisfies sd-efficiency, sd-envy-freeness, ordinal fairness, and upper invariance, while MRP satisfies ex-post-efficiency, sd-strategyproofness, and upper invariance, recovering the properties of PS and RP. Besides, we propose a hybrid mechanism, multi-type general dictatorship (MGD), combining the ideas of MPS and MRP, which satisfies sd-efficiency, equal treatment of equals and decomposability under the unrestricted domain of partial order preferences.

A New Extensible Continuum Manipulator Using Flexible Parallel Mechanism and Rigid Motion Transmission

2021 ◽  
pp. 1-23
Author(s):  
Yujiong Liu ◽  
Pinhas Ben-Tzvi
Keyword(s):  
Parallel Mechanism ◽  
Kinematic Model ◽  
Rigid Motion ◽  
Artificial Muscle ◽  
Dexterous Manipulation ◽  
Base Extension ◽  
Hybrid Mechanism ◽  
Continuum Robot ◽  
Kinematic Analyses ◽  
Continuum Manipulator

Abstract An extensible continuum manipulator (ECM) has specific advantages over its non-extensible counterparts. For instance, in certain applications, such as minimally invasive surgery or pipe inspection, the base motion might be limited or disallowed. The additional extensibility provides the robot with more dexterous manipulation and a larger workspace. Existing continuum robot designs achieve extensibility mainly through artificial muscle/pneumatic, extensible backbone, concentric tube, and base extension, etc. This paper proposes a new way to achieve this additional motion degree of freedom by taking advantage of the rigid coupling hybrid mechanism concept and a flexible parallel mechanism. More specifically, a rack and pinion set is used to transmit the motion of the i-th subsegment to drive the (i+1)-th subsegment. A six-chain flexible parallel mechanism is used to generate the desired spatial bending and one extension mobility for each subsegment. This way, the new manipulator can achieve tail-like spatial bending and worm-like extension at the same time. Simplified kinematic analyses are conducted to estimate the workspace and the motion non-uniformity. A proof-of-concept prototype was integrated to verify the mechanism’s mobility and to evaluate the kinematic model accuracy. The results show that the proposed mechanism achieved the desired mobilities with a maximum extension ratio of 32.2% and a maximum bending angle of 80 degrees.

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