Superposed epoch analysis of coupling mechanisms captured by meteor radars during sudden stratospheric warmings

<p class="western" align="justify"><span lang="en-GB">Previous studies that analysed the mesosphere and lower thermosphere (MLT) dynamics during sudden stratospheric warmings (SSWs) were limited only to particular SSWs or focused on a particular station representative only for some regions. Here we describe a comprehensive study of the average meteorological conditions during SSWs with a special focus on the general contribution of planetary (PW) and gravity (GW) waves as primary coupling mechanisms between lower and upper atmosphere. The average meteorological conditions in the MLT during SSWs were analyzed using a superposed epoch analysis (Denton et al., 2019) of meteor radar measurements for stations in the northern (NH: Collm, Kiruna, Sodankyla, CMOR) and the southern hemisphere (SH: Rio Grande, Davis, Rothera) for the altitude range of 80–100 km Using the adaptive spectral filtering method (Stober et al., 2021), we study in detail PW and GW characteristics in addition to measured zonal and meridional wind components in a time period from 2000 to 2020.</span></p> <p class="western" align="justify"><span lang="en-GB">In the NH the zonal wind is typically decreasing from around two weeks before the SSW onset, corresponding to an increased PW activity. Around the SSW onset, latitudinal differences in the zonal wind component as well as the PW activity can be seen. In the weeks before the SSW onset, the stations in the NH also show an increased level of GW kinetic energy. The meridional wind at the NH stations fluctuates with a periodicity of about 10 days before and around the onset. In contrast to previous studies (e.g. Yasui et al., 2016), the measurements in the SH are consistent with the inter-hemispheric coupling hypothesis. The expected downward shift of GW drag (Körnich and Becker, 2010) was reproduced by a downward travelling layer of enhanced GW activity at Davis and Rio Grande. Finally, the role of the terdiurnal tide in the GW energy composite is considered.</span></p>

Oxygenated hemoglobin signal provides greater predictive performance of experimental condition than de-oxygenated

Continuous-wave functional near-infrared spectroscopy (fNIRS) neuroimaging provides an estimate of relative changes in oxygenated and de-oxygenated hemoglobin content, from which regional neural activity is inferred. The relation between both signals is governed by neurovascular coupling mechanisms. However, the magnitude of concentration changes and the contribution of noise sources to each chromophore is unique. Subsequently, it is not apparent if either chromophore signal practically provides greater information about the underlying neural state and relation to an experimental condition. To assess this question objectively, we applied a machine-learning approach to four datasets and evaluated which hemoglobin signal best differentiated between experimental conditions. To further ensure the objective nature of the analysis, the algorithm utilized all samples from the epoched data rather than pre-selected features. Regardless of experimental task, brain region, or stimulus, the oxygenated hemoglobin signal was better able to differentiate between conditions than the de-oxygenated signal. Incorporating both signals into the analysis provided no additional improvement over oxygenated hemoglobin alone. These results indicate that oxyhemoglobin is the most informative fNIRS signal in relation to experimental condition.

Multi-parametric characterization of brain-wide hemodynamic and calcium responses to sensory stimulation in mice

Modern optical neuroimaging approaches are expanding our ability to elucidate complex brain function. Diverse imaging contrasts enable direct observation of neural activity with functional sensors along with the induced hemodynamic responses. To date, decoupling the complex interplay of neurovascular coupling and dynamical physiological states has remained challenging when employing single-modality functional neuroimaging tools. We devised a hybrid fluorescence optoacoustic tomography (FLOT) platform combined with a custom data processing pipeline based on statistical parametric mapping, accomplishing the first simultaneous noninvasive observation of both direct and indirect brain-wide activation patterns with optical contrast. Correlated changes in the oxy- and deoxygenated hemoglobin, total hemoglobin, oxygen saturation and rapid GCaMP6f fluorescence signals were observed in response to peripheral sensory stimulation. While the concurrent epifluorescence served to corroborate and complement the functional optoacoustic observations, the latter further aided in decoupling the rapid calcium responses from the slowly varying background in the fluorescence recordings mediated by hemodynamic changes. The hybrid imaging platform expands the capabilities of conventional neuroimaging methods to provide more comprehensive functional readings for studying neurovascular and neurometabolic coupling mechanisms and related diseases.

Normal & reversed spin mobility in a diradical by electron-vibration coupling

Abstractπ−conjugated radicals have great promise for use in organic spintronics, however, the mechanisms of spin relaxation and mobility related to radical structural flexibility remain unexplored. Here, we describe a dumbbell shape azobenzene diradical and correlate its solid-state flexibility with spin relaxation and mobility. We employ a combination of X-ray diffraction and Raman spectroscopy to determine the molecular changes with temperature. Heating leads to: i) a modulation of the spin distribution; and ii) a “normal” quinoidal → aromatic transformation at low temperatures driven by the intramolecular rotational vibrations of the azobenzene core and a “reversed” aromatic → quinoidal change at high temperatures activated by an azobenzene bicycle pedal motion amplified by anisotropic intermolecular interactions. Thermal excitation of these vibrational states modulates the diradical electronic and spin structures featuring vibronic coupling mechanisms that might be relevant for future design of high spin organic molecules with tunable magnetic properties for solid state spintronics.

Functional (un-)Coupling: Impairment, Compensation, and Future Progression in Alzheimer's Disease

Background: Functional (un-)coupling (task-related change of functional connectivity) between different sites of the brain is a mechanism of general importance for cognitive processes. In Alzheimer's disease (AD), prior research identified diminished cortical connectivity as a hallmark of the disease. However, little is known about the relation between the amount of functional (un-)coupling and cognitive performance and decline in AD. Method: Cognitive performance (based on CERAD-Plus scores) and electroencephalogram (EEG)-based functional (un-)coupling measures (connectivity changes from rest to a Face-Name-Encoding task) were assessed in 135 AD patients (age: M = 73.8 years; SD = 9.0). Of these, 68 patients ( M = 73.9 years; SD = 8.9) participated in a follow-up assessment of their cognitive performance 1.5 years later. Results: The amounts of functional (un-)coupling in left anterior-posterior and homotopic interhemispheric connections in beta1-band were related to cognitive performance at baseline (β = .340; p < .001; β = .274; P = .001, respectively). For both markers, a higher amount of functional coupling was associated with better cognitive performance. Both markers also were significant predictors for cognitive decline. However, while patients with greater functional coupling in left anterior-posterior connections declined less in cognitive performance (β = .329; P = .035) those with greater functional coupling in interhemispheric connections declined more (β = −.402; P = .010). Conclusion: These findings suggest an important role of functional coupling mechanisms in left anterior–posterior and interhemispheric connections in AD. Especially the complex relationship with cognitive decline in AD patients might be an interesting aspect for future studies.

Chemoselective nickel-catalyzed coupling through substrate photoexcitation

Metallaphotoredox catalysis combines the well-established mechanisms of transition-metal-catalyzed cross-coupling reactions with one-electron redox manipulations enabled by light. In most cases, a transition metal or organic dye serves as the photoredox catalyst while a ground-state Pd or Ni catalyst performs the organometallic steps. Cross-coupling mechanisms that rely on direct photoexcitation of a light-absorbing substrate have the potential to access distinct mechanisms and deliver unique selectivity based on the substrate’s excited-state properties. In this report, we describe a photoinduced, Ni-catalyzed Suzuki–Miyaura cross coupling reaction that selectively functionalizes BODIPY chromophores, a versatile class of tunable, bright, photostable fluorophores. Using a bis-iodo BODIPY substrate, the selectivity for mono- vs. bis-arylation was found to be governed by a remote substituent that subtly alters the excited-state properties of the substrate. Consistent with a substrate photoexcitation mechanism, high chemoselectivity is also observed in mixtures of chromophores with distinct excited-state properties. This reaction is compatible with a variety of substituted BODIPY chromophores and boronic acids and esters, enabling the rapid synthesis of unsymmetrically-substituted chromophores.

Type Synthesis of Fully Decoupled Three Translational Parallel Mechanism with Closed loop Units and High Stiffness

In this paper, a new synthesis method of fully decoupled three translational (3T) parallel mechanisms (PMs) with closed loop units and high stiffness is proposed based on screw theory. Firstly, a new criterion for the full decoupled of PMs is presented that the reciprocal product of the transmission wrenc h screw matrix and the output twist screw matrix of PMs is a diagonal matrix, and all elements on the main diagonal are nonzero constants. The forms of the transmission wrench screws are determined by the criterion. Secondly, the forms of the actuated and unactuated screws can be obtained according to their relationships with the transmission wrench screws. The basic decoupled limbs are generated by combination of the above actuated and unactuated screws. Finally, a closed loop units construction method is investigated to apply the decoupled mechanisms in a better way on the high stiffness occasion. The closed loop units are constructed in the basic decoupled limbs to generate a high stiffness fully decoupled 3T PM. Kinematic and stiffness analys e s show that the Jacobian matrix is a diagonal matrix, and the stiffness is obviously higher than that of the orthogonal coupling mechanisms, which verifies the correctness of the proposed synthesis method. The mechanism synthesized by this method has a good applicati on prospect in vehicle durability test platform.