Estimating the internal elastic membrane cross-sectional area of coronary arteries autonomously using optical coherence tomography images

2017 ◽  
Author(s):  
Max L. Olender ◽  
Lambros S. Athanasiou ◽  
Jose M. de la Torre Hernandez ◽  
Tamara Garcia Camarero ◽  
Jose D. Cascon ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Arteries ◽  
Cross Sectional Area ◽  
Elastic Membrane ◽  
Optical Coherence ◽  
Sectional Area ◽  
Cross Sectional

Optical coherence tomography-based evaluation of in-stent neoatherosclerosis in lesions with more than 50% neointimal cross-sectional area stenosis

2013 ◽  
Vol 9 (8) ◽  
pp. 945-951 ◽  
Author(s):  
Seung-Yul Lee ◽  
Dong-Ho Shin ◽  
Gary S. Mintz ◽  
Jung-Sun Kim ◽  
Byeong-Keuk Kim ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cross Sectional Area ◽  
Optical Coherence ◽  
Sectional Area ◽  
Cross Sectional

Coupling Pressure Sensing with Optical Coherence Tomography to Evaluate the Internal Nasal Valve

2020 ◽  
pp. 000348942094419
Author(s):  
Amir A. Hakimi ◽  
Giriraj K. Sharma ◽  
Tuan Ngo ◽  
Andrew E. Heidari ◽  
Christopher D. Badger ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Long Range ◽  
Pressure Sensor ◽  
Cross Sectional Area ◽  
Intraluminal Pressure ◽  
Optical Coherence ◽  
Sectional Area ◽  
Nasal Valve ◽  
Cross Sectional ◽  
Normal Respiration

Purpose: To evaluate endoscopic long-range optical coherence tomography system combined with a pressure sensor to concurrently measure internal nasal valve cross-sectional area and intraluminal pressure. Methods: A pressure sensor was constructed using an Arduino platform and calibrated using a limiter-controlled vacuum system and industrial absolute pressure gauge. Long-range optical coherence tomography imaging and pressure transduction were performed concurrently in the naris of eight healthy adult subjects during normal respiration and forced inspiration. The internal nasal valve was manually segmented using Mimics software and cross-sectional area was measured. Internal nasal valve cross-sectional area measurements were correlated with pressure recordings. Results: Mean cross-sectional area during forced inspiration was 6.49 mm2. The mean change in pressure between normal respiration and forceful inspiration was 12.27 mmHg. The direct correlation between pressure and cross-sectional area as measured by our proposed system was reproducible among subjects. Conclusions: Our results demonstrate a direct correlation between internal nasal valve cross-sectional area and nasal airflow during inspiration cycles. Endoscopic long-range optical coherence tomography coupled with a pressure sensor serves as a useful tool to quantify the dynamic behavior of the internal nasal valve. Level of Evidence: N/A

Features and Outcomes of Patients with Calcified Nodules at Culprit Lesions of Acute Coronary Syndrome: An Optical Coherence Tomography Study

Cardiology ◽  
2018 ◽  
Vol 139 (2) ◽  
pp. 90-100 ◽  
Author(s):  
Nobuaki Kobayashi ◽  
Masamichi Takano ◽  
Masafumi Tsurumi ◽  
Yusaku Shibata ◽  
Suguru Nishigoori ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Acute Coronary Syndrome ◽  
Plaque Rupture ◽  
Target Lesion ◽  
Cross Sectional Area ◽  
Optical Coherence ◽  
Sectional Area ◽  
Culprit Lesion ◽  
Cross Sectional ◽  
Coronary Syndrome

Objectives: We sought to clarify clinical features and outcomes related to calcified nodules (CN) compared with plaque rupture (PR) and plaque erosion (PE) detected by optical coherence tomography (OCT) at the culprit lesions in patients with acute coronary syndrome (ACS). Methods: Based on OCT findings for culprit lesion plaque morphologies, ACS patients with analyzable OCT images (n = 362) were classified as CN, PR, PE, and other. Results: The prevalence of CN, PR, and PE was 6% (n = 21), 45% (n = 163), and 41% (n = 149), respectively. Patients with CN were older (median 71 vs. 65 years, p = 0.03) and more diabetic (71 vs. 35%, p = 0.002) than those without CN. In OCT findings, the distal reference lumen cross-sectional area (median 4.2 vs. 5.2 mm2, p = 0.048) and the postintervention minimum lumen cross-sectional area (median 4.5 vs. 5.3 mm2, p = 0.04) were smaller in lesions with CN than in those without. Kaplan-Meier estimate survival curves showed that the 500-day survival without target lesion revascularization (TLR) was lower (p = 0.011) for patients with CN (72.9%) than for those with PR (89.3%) or PE (94.8%). Conclusions: ACS patients with CN at the culprit lesion had more TLR compared to those with PR or PE.

scholarly journals Influence of malformation of right coronary artery originating from the left sinus on the hemodynamic environment

2020 ◽  
Author(s):  
Mengyang Cong ◽  
Xingming Xu ◽  
Jianfeng Qiu ◽  
Shun Dai ◽  
Chuanzhi Chen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Right Coronary Artery ◽  
Clinical Symptoms ◽  
Element Model ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
The Cross ◽  
The Right

Abstract Background: The Anomalous origin of the Right Coronary Artery (RCA) from the Left Coronary artery sinus(AORL) is one of the abnormal origins of the coronary arteries. Most of these issues seldom have effects on human health, but some individuals may have symptoms such as myocardial ischaemia or even sudden death. Recently, researchers are studying AORL through clinical cases, but study based on computational fluid dynamics (CFD) is rarely seen. In this study, haemodynamic changes between normal origin of the RCA and AORL are compared according to numerical simulation results.Methods: Realistic three-dimensional models of 16 normal right coronary arteries and 26 abnormal origins of the right coronary arteries were reconstructed, respectively. The blood flow was numerically simulated using software ANSYS. This study involves one-way fluid-solid coupling finite element model in which the blood is assumed to be incompressible Newtonian fluid, and the vessel is assumed to be isotropic, linear elastic material.Results: The differences of the cross-sectional area at the inlet between the normal group and the abnormal group was significant ( P <0.0001). There were significant differences in the volumetric flow ( P <0.0001) and the pressure ( P =0.0001). There were positive correlations with the ratio of the cross-sectional area of the RCA to the inlet area of the ascending aorta (AAO) and the ratio of the inlet volumetric flow of the RCA to the volumetric flow of the AAO, in both the normal ( P =0.0001, r=0.8198) and abnormal ( P =0.0199, r=0.4925) group.Conclusion: This study shows that the cross-sectional area of the inlet of AORL may cause ischaemia symptoms, and the results may contribute to the further understanding of the clinical symptoms of AORL based on the haemodynamics.

scholarly journals Short-term effect of non-preserved cationic oil in-water ophthalmic emulsion on tear meniscus parameters of healthy individuals in a prospective, controlled pilot study

2021 ◽  
Vol 10 (1) ◽  
pp. 5-10
Author(s):  
Olga E. Makri ◽  
Iasonas Tsekouras ◽  
Stylianos Mastronikolis ◽  
Constantinos D. Georgakopoulos
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Residence Time ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Single Drop ◽  
Cross Sectional ◽  
Oil In Water ◽  
Tear Meniscus ◽  
Parameter Values

Background: This study investigated the effect of instilling a single drop of non-preserved cationic oil-in-water ophthalmic emulsion (Cationorm®) on the lower (LTM) and upper tear meniscus (UTM) parameters of normal eyes. Methods: In this prospective, single-center, non-randomized, controlled pilot study, optical coherence tomography was used to estimate the UTM and LTM height, depth, and cross-sectional area in participants without a history of dry eye disease. In the right eye (study eye), we instilled one drop of Cationorm® in the lower conjunctival sac. Scans of the tear menisci were acquired at baseline, before the instillation, and at 5, 15, and 30 min thereafter. Control scans of the left eye (control eye) were obtained at the same timepoints. The tear meniscus parameters of the study eye were compared with the control eye at each timepoint. Results: Twenty subjects (11 male and 9 female; mean ± standard deviation of age: 37.8 ± 10.9 years) were included in the study. Compared to the control eye, instillation of a single drop of Cationorm® resulted in significantly higher LTM parameter values and a higher UTM cross-sectional area up to 30 min after instillation (all P < 0.05). The UTM height and depth were significantly greater in the study eye than in the control eye up to 5 min (P < 0.001 and 0.007, respectively) and 15-min (P = 0.045, and 0.002, respectively) after Cationorm® instillation. In the study eye, Cationorm® resulted in a significant increase in LTM parameter values up to 30 min post-instillation (all P < 0.001). The UTM height was significantly greater up to 15 min post-instillation than at baseline. The UTM depth and area increased significantly from baseline to 5 min after instillation. Conclusions: Cationorm® seems to have a prolonged residence time on the ocular surface of healthy subjects as indicated by LTM parameters and to a lesser extent by UTM parameters. Keywords: ophthalmic emulsion, cationorm, upper tear meniscus, lower tear meniscus, spectral domain-optical coherence tomography, SD-OCT, residence time

Abstract 203: Evaluation of Acute Radial Artery Injury Following Transradial Percutaneous Coronary Intervention by Optical Coherence Tomography

2012 ◽  
Vol 5 (suppl_1) ◽  
Author(s):  
Vinay Arora ◽  
Anupama Shivaraju ◽  
Mladen Vidovich ◽  
Adhir Shroff
Keyword(s):  
Optical Coherence Tomography ◽  
Percutaneous Coronary Intervention ◽  
Radial Artery ◽  
Coronary Intervention ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Artery Injury ◽  
Percutaneous Coronary ◽  
Transradial Pci

Background: Recent evidence has shown a reduced bleeding risk and resultant decreased morbidity and mortality when the transradial approach is utilized over the transfemoral approach for percutaneous coronary intervention (PCI). However, transradial catheterization may introduce acute and/or chronic injury to the radial artery limiting its use for future procedures and as a bypass conduit. Our goal was to utilize optical coherence tomography (OCT) to evaluate the incidence of acute radial artery injury in patients following transradial PCI. Methods: In this observational study OCT (C7 Dragonfly catheter, St. Jude Medical Systems, St. Paul, MN) was used to evaluate the radial artery of 25 patients at the University of Illinois and Jesse Brown Veterans Affairs Medical Centers in Chicago, IL following transradial PCI. Specific injuries assessed for included radial artery dissection and thrombus formation. Diameter and cross sectional area of the artery were taken proximally and distally. Measurements were taken independently by two separate readers to account for inter-reader variability. Results: The radial artery was assessed in 25 patients following transradial PCI. The mean BMI of our patient population was 27.8 kg/m2. A 5Fr sheath was used in 24% (n=6) cases and a 6Fr sheath was utilized for the remaining 19 cases. In 8 cases the sheath was upsized from a 5 to 6 F. The average length of artery scanned was 39.4mm with a mean proximal cross sectional area of 7.56 mm2 and distal area of 7.08 mm2. An average of 4.4 catheter exchanges were made per case. A small intimal tear was noted in the radial artery of one patient. No other dissections or thrombi were noted. Conclusion: Based on our initial observation, the incidence of acute radial artery injury following transradial PCI is very low (1/25) and overall transradial PCI is a safe modality. When compared with prior studies we believe the factors that decreased the incidence of acute radial artery injury in our population were related to larger arterial cross sectional area, higher mean BMI, and ultimately a lower sheath size to artery diameter ratio.

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