Leveraging non-lattice subgraphs for suggestion of new concepts for SNOMED CT

Author(s):  
Xubing Hao ◽  
Rashmie Abeysinghe ◽  
Fengbo Zheng ◽  
Licong Cui
Keyword(s):  
2021 ◽  
Vol 21 (S7) ◽  
Author(s):  
Fengbo Zheng ◽  
Rashmie Abeysinghe ◽  
Licong Cui

Abstract Background As biomedical knowledge is rapidly evolving, concept enrichment of biomedical terminologies is an active research area involving automatic identification of missing or new concepts. Previously, we prototyped a lexical-based formal concept analysis (FCA) approach in which concepts were derived by intersecting bags of words, to identify potentially missing concepts in the National Cancer Institute (NCI) Thesaurus. However, this prototype did not handle concept naming and positioning. In this paper, we introduce a sequenced-based FCA approach to identify potentially missing concepts, supporting concept naming and positioning. Methods We consider the concept name sequences as FCA attributes to construct the formal context. The concept-forming process is performed by computing the longest common substrings of concept name sequences. After new concepts are formalized, we further predict their potential positions in the original hierarchy by identifying their supertypes and subtypes from original concepts. Automated validation via external terminologies in the Unified Medical Language System (UMLS) and biomedical literature in PubMed is performed to evaluate the effectiveness of our approach. Results We applied our sequenced-based FCA approach to all the sub-hierarchies under Disease or Disorder in the NCI Thesaurus (19.08d version) and five sub-hierarchies under Clinical Finding and Procedure in the SNOMED CT (US Edition, March 2020 release). In total, 1397 potentially missing concepts were identified in the NCI Thesaurus and 7223 in the SNOMED CT. For NCI Thesaurus, 85 potentially missing concepts were found in external terminologies and 315 of the remaining 1312 appeared in biomedical literature. For SNOMED CT, 576 were found in external terminologies and 1159 out of the remaining 6647 were found in biomedical literature. Conclusion Our sequence-based FCA approach has shown the promise for identifying potentially missing concepts in biomedical terminologies.


Author(s):  
Arthur V. Jones

In comparison with the developers of other forms of instrumentation, scanning electron microscope manufacturers are among the most conservative of people. New concepts usually must wait many years before being exploited commercially. The field emission gun, developed by Albert Crewe and his coworkers in 1968 is only now becoming widely available in commercial instruments, while the innovative lens designs of Mulvey are still waiting to be commercially exploited. The associated electronics is still in general based on operating procedures which have changed little since the original microscopes of Oatley and his co-workers.The current interest in low-voltage scanning electron microscopy will, if sub-nanometer resolution is to be obtained in a useable instrument, lead to fundamental changes in the design of the electron optics. Perhaps this is an opportune time to consider other fundamental changes in scanning electron microscopy instrumentation.


1971 ◽  
Vol 4 (2) ◽  
pp. 431-443
Author(s):  
LaVonne Bergstrom ◽  
Janet Stewart

2020 ◽  
Vol 25 (04) ◽  
pp. 9-9
Keyword(s):  

Das Bundesforschungsministerium hat eine Pilotlizenz für den internationalen Terminologiestandard SNOMED CT erworben.


2017 ◽  
Vol 47 (2) ◽  
pp. 350-359
Author(s):  
Aoife Lynch

This essay views science as a creative mask for the poetry and philosophy of W.B. Yeats. It explores the changing worldview which occurred at the beginning of the twentieth century with the discovery of wave-particle duality by Max Planck in 1900. It considers the new concepts of reality which arose at this time in relation to modernism and Yeats's response to the paradigmatic change of era he was a part of. Accordingly, the poet's understanding of universal history in A Vision (1925, 1937) is used alongside close readings of his poetry to evince an argument which unites that poetry with philosophy, scientific theory, and modernism as aspects of one universe of knowledge which refracts different aspects of itself through the prism of time.


Sign in / Sign up

Export Citation Format

Share Document