Advanced Giant Magnetoresistance (GMR) sensors for Selective-Change Driven (SCD) circuits

2021 ◽  
Author(s):  
Candid Reig ◽  
Fernando Pardo ◽  
Jose A. Boluda ◽  
Francisco Vegara ◽  
Maria D. Cubells-Beltran ◽  
...  
Keyword(s):  
Giant Magnetoresistance ◽  
Gmr Sensors ◽  
Selective Change

scholarly journals A tandem giant magnetoresistance assay for one-shot quantification of clinically relevant concentrations of N-terminal pro-B-type natriuretic peptide in human blood

2021 ◽  
Author(s):  
Fanda Meng ◽  
Weisong Huo ◽  
Jie Lian ◽  
Lei Zhang ◽  
Xizeng Shi ◽  
...  
Keyword(s):  
Detection Limit ◽  
Giant Magnetoresistance ◽  
Dynamic Range ◽  
Point Of Care ◽  
Sample Volume ◽  
Small Sample ◽  
Broad Dynamic Range ◽  
Gmr Sensors ◽  
Gmr Sensor ◽  
Sample Volume Requirement

AbstractWe report a microfluidic sandwich immunoassay constructed around a dual-giant magnetoresistance (GMR) sensor array to quantify the heart failure biomarker NT-proBNP in human plasma at the clinically relevant concentration levels between 15 pg/mL and 40 ng/mL. The broad dynamic range was achieved by differential coating of two identical GMR sensors operated in tandem, and combining two standard curves. The detection limit was determined as 5 pg/mL. The assay, involving 53 plasma samples from patients with different cardiovascular diseases, was validated against the Roche Cobas e411 analyzer. The salient features of this system are its wide concentration range, low detection limit, small sample volume requirement (50 μL), and the need for a short measurement time of 15 min, making it a prospective candidate for practical use in point of care analysis.

Giant Magnetoresistance (GMR) Sensors

2013 ◽  
Author(s):  
Candid Reig ◽  
Susana Cardoso ◽  
Subhas Chandra Mukhopadhyay
Keyword(s):  
Giant Magnetoresistance ◽  
Gmr Sensors

scholarly journals Evaluation of In-Flow Magnetoresistive Chip Cell—Counter as a Diagnostic Tool

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 105 ◽  
Author(s):  
Manon Giraud ◽  
François-Damien Delapierre ◽  
Anne Wijkhuisen ◽  
Pierre Bonville ◽  
Mathieu Thévenin ◽  
...  
Keyword(s):  
Giant Magnetoresistance ◽  
Limit Of Detection ◽  
Malignant Cell ◽  
Elisa Test ◽  
Great Sensitivity ◽  
Actual System ◽  
Whole Cells ◽  
Gmr Sensors ◽  
Gmr Sensor ◽  
Sensor Detection

Inexpensive simple medical devices allowing fast and reliable counting of whole cells are of interest for diagnosis and treatment monitoring. Magnetic-based labs on a chip are one of the possibilities currently studied to address this issue. Giant magnetoresistance (GMR) sensors offer both great sensitivity and device integrability with microfluidics and electronics. When used on a dynamic system, GMR-based biochips are able to detect magnetically labeled individual cells. In this article, a rigorous evaluation of the main characteristics of this magnetic medical device (specificity, sensitivity, time of use and variability) are presented and compared to those of both an ELISA test and a conventional flow cytometer, using an eukaryotic malignant cell line model in physiological conditions (NS1 murine cells in phosphate buffer saline). We describe a proof of specificity of a GMR sensor detection of magnetically labeled cells. The limit of detection of the actual system was shown to be similar to the ELISA one and 10 times higher than the cytometer one.

Biosensor Based on Giant Magnetoresistance Material

2010 ◽  
Vol 1 (3) ◽  
pp. 1-15 ◽  
Author(s):  
Mitra Djamal
Keyword(s):  
Giant Magnetoresistance ◽  
Large Scale ◽  
Single Chip ◽  
Biomolecule Detection ◽  
Novel Approach ◽  
Large Scale Integration ◽  
Gmr Sensors ◽  
Gmr Sensor ◽  
Scale Integration ◽  
The Magnetic Field

In recent years, giant magnetoresistance (GMR) sensors have shown a great potential as sensing elements for biomolecule detection. The resistance of a GMR sensor changes with the magnetic field applied to the sensor, so that a magnetically labeled biomolecule can induce a signal. Compared with the traditional optical detection that is widely used in biomedicine, GMR sensors are more sensitive, portable, and give a fully electronic readout. In addition, GMR sensors are inexpensive and the fabrication is compatible with the current VLSI (Very Large Scale Integration) technology. In this regard, GMR sensors can be easily integrated with electronics and microfluidics to detect many different analytes on a single chip. In this article, the authors demonstrate a comprehensive review on a novel approach in biosensors based on GMR material.

Giant Magnetoresistance Imaging for NDE of Conductive Materials

1999 ◽  
Vol 591 ◽  
Author(s):  
E. S. Boltz ◽  
S. G. Albanna ◽  
A. R. Stallings ◽  
Y. H. Spooner ◽  
J. P. Abeyta
Keyword(s):  
Eddy Current ◽  
Giant Magnetoresistance ◽  
High Spatial Resolution ◽  
Low Frequency ◽  
High Sensitivity ◽  
Low Noise ◽  
Conductive Materials ◽  
Gmr Sensors ◽  
Current Sensors ◽  
Gmr Sensor

ABSTRACTTraditional coil-based eddy-current sensors are severely limited in their ability to detect small buried defects, defects under fasteners and deeply buried cracks and corrosion. TPL has developed eddy-current sensors and arrays based on the use of Giant Magnetoresistance (GMR) sensor elements. GMR offers high sensitivity, very wide bandwidth and low noise from DC to over 1 GHz. Coupled with the ability to fabricate GMR sensors with micron-level dimensions, these new eddy-current sensors offer an ideal technology for inspections requiring high spatial resolution and low-frequency, deeply-penetrating fields.

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