Pulse laser assisted optical tweezers for biomedical applications

2012 ◽  
Author(s):  
T. Sugiura ◽  
S. Maeda ◽  
A. Honda
Keyword(s):  
Optical Tweezers ◽  
Pulse Laser ◽  
Biomedical Applications

scholarly journals Plasmonic Tweezers towards Biomolecular and Biomedical Applications

2019 ◽  
Vol 9 (17) ◽  
pp. 3596
Author(s):  
Xue Han ◽  
Changsen Sun
Keyword(s):  
Optical Tweezers ◽  
Biomedical Applications ◽  
Short Review ◽  
Nanoscale Particles ◽  
Level Of Significance

With the capability of confining light into subwavelength scale, plasmonic tweezers have been used to trap and manipulate nanoscale particles. It has huge potential to be utilized in biomolecular research and practical biomedical applications. In this short review, plasmonic tweezers based on nano-aperture designs are discussed. A few challenges should be overcome for these plasmonic tweezers to reach a similar level of significance as the conventional optical tweezers.

From optical tweezers to optical forced oscillation: principles and potential biomedical applications

2007 ◽  
Author(s):  
Ming-Tzo Wei ◽  
Shang-Ling Liu ◽  
Te-Yu Tseng ◽  
A. Karmenyan ◽  
Arthur Chiou
Keyword(s):  
Optical Tweezers ◽  
Biomedical Applications ◽  
Forced Oscillation

Optical Tweezers with Assistance of Sub-Microsecond-Duration Pulse Laser Beam

2012 ◽  
Vol 5 (4) ◽  
pp. 042701 ◽  
Author(s):  
Saki Maeda ◽  
Tadao Sugiura ◽  
Kotaro Minato
Keyword(s):  
Laser Beam ◽  
Optical Tweezers ◽  
Pulse Laser ◽  
Pulse Laser Beam

scholarly journals Holographic acoustic tweezers

2018 ◽  
Vol 116 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Asier Marzo ◽  
Bruce W. Drinkwater
Keyword(s):  
Optical Tweezers ◽  
Biomedical Applications ◽  
Soft Matter ◽  
Input Power ◽  
Multiple Objects ◽  
Multiple Particles ◽  
Holographic Optical Tweezers ◽  
Wide Range ◽  
Acoustic Tweezers ◽  
Trapping Forces

Acoustic tweezers use sound radiation forces to manipulate matter without contact. They provide unique characteristics compared with the more established optical tweezers, such as higher trapping forces per unit input power and the ability to manipulate objects from the micrometer to the centimeter scale. They also enable the trapping of a wide range of sample materials in various media. A dramatic advancement in optical tweezers was the development of holographic optical tweezers (HOT) which enabled the independent manipulation of multiple particles leading to applications such as the assembly of 3D microstructures and the probing of soft matter. Now, 20 years after the development of HOT, we present the realization of holographic acoustic tweezers (HAT). We experimentally demonstrate a 40-kHz airborne HAT system implemented using two 256-emitter phased arrays and manipulate individually up to 25 millimetric particles simultaneously. We show that the maximum trapping forces are achieved once the emitting array satisfies Nyquist sampling and an emission phase discretization below π/8 radians. When considered on the scale of a wavelength, HAT provides similar manipulation capabilities as HOT while retaining its unique characteristics. The examples shown here suggest the future use of HAT for novel forms of displays in which the objects are made of physical levitating voxels, assembly processes in the micrometer and millimetric scale, as well as positioning and orientation of multiple objects which could lead to biomedical applications.

Surface Micropatterning of Pure Titanium for Biomedical Applications Via High Energy Pulse Laser Peening

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Ninggang Shen ◽  
Hongtao Ding ◽  
Robert Bowers ◽  
Yin Yu ◽  
Chelsey N. Pence ◽  
...  
Keyword(s):  
Shock Wave ◽  
Mechanical Strength ◽  
Pulse Laser ◽  
Biomedical Applications ◽  
Pure Titanium ◽  
Strong Shock ◽  
High Energy ◽  
Laser Peening ◽  
Biomedical Implant ◽  
Energy Pulse

Pure titanium is an ideal material for biomedical implant applications for its superior biocompatibility, but it lacks of the mechanical strength required in these applications compared with titanium alloys. This research is concerned with an innovative laser peening-based material process to improve the mechanical strength and cell attachment property of pure titanium in biomedical applications. Evidence has shown that engineered surface with unsmooth topologies will contribute to the osteoblast differentiation in human mesenchymal pre-osteoblastic cells, which is helpful to avoid long-term peri-abutment inflammation issues for the dental implant therapy with transcutaneous devices. However, surface quality is difficult to control or mechanical strength is not enhanced using conventional approaches. In this paper, a novel high energy pulse laser peening (HEPLP) process is proposed to both improve the mechanical strength and introduce a micropattern into the biomedical implant material of a commercially pure Titanium (cpTi). The strong shock wave generated by HEPLP presses a stainless steel grid, used as a stamp, on cpTi foils to imprint a micropattern. To understand the basic science during the process, the HEPLP induced shock wave pressure profile and history are modeled by a multiphysics hydrodynamic numerical analysis. The micropatterns and strength enhancement are then simulated using a dislocation density-based finite element (FE) framework. Finally, cell culture tests are conducted to investigate the biomedical performance of the patterned surface.

scholarly journals Tele–Robotic Platform for Dexterous Optical Single-Cell Manipulation

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 677 ◽  
Author(s):  
Edison Gerena ◽  
Florent Legendre ◽  
Akshay Molawade ◽  
Youen Vitry ◽  
Stéphane Régnier ◽  
...  
Keyword(s):  
Single Cell ◽  
Optical Tweezers ◽  
Biomedical Applications ◽  
High Speed ◽  
Cell Manipulation ◽  
Optical Traps ◽  
A Cell ◽  
Six Dof ◽  
Master Device ◽  
Single Cell Manipulation

Single-cell manipulation is considered a key technology in biomedical research. However, the lack of intuitive and effective systems makes this technology less accessible. We propose a new tele–robotic solution for dexterous cell manipulation through optical tweezers. A slave-device consists of a combination of robot-assisted stages and a high-speed multi-trap technique. It allows for the manipulation of more than 15 optical traps in a large workspace with nanometric resolution. A master-device (6+1 degree of freedom (DoF)) is employed to control the 3D position of optical traps in different arrangements for specific purposes. Precision and efficiency studies are carried out with trajectory control tasks. Three state-of-the-art experiments were performed to verify the efficiency of the proposed platform. First, the reliable 3D rotation of a cell is demonstrated. Secondly, a six-DoF teleoperated optical-robot is used to transport a cluster of cells. Finally, a single-cell is dexterously manipulated through an optical-robot with a fork end-effector. Results illustrate the capability to perform complex tasks in efficient and intuitive ways, opening possibilities for new biomedical applications.

Developments of pulse laser assist optical tweezers (PLAT) for in vivo manipulation

2011 ◽  
Author(s):  
Saki Maeda ◽  
Tadao Sugiura ◽  
Kotaro Minato
Keyword(s):  
Optical Tweezers ◽  
Pulse Laser
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