Pulse Vaccination Strategy in the SEIR Epidemic Dynamics Model with Latent Period

Author(s):  
Wei Wei ◽  
Meng Li
2020 ◽  
Author(s):  
Sarah C. Brüningk ◽  
Juliane Klatt ◽  
Madlen Stange ◽  
Alfredo Mari ◽  
Myrta Brunner ◽  
...  

Transmission chains within cities provide an important contribution to case burden and economic impact during the ongoing COVID-19 pandemic, and should be a major focus for preventive measures to achieve containment. Here, at very high spatio-temporal resolution, we analysed determinants of SARS-CoV-2 transmission in a medium-sized European city. We combined detailed epidemiological, mobility, and socioeconomic data-sets with whole genome sequencing during the first SARS-CoV-2 wave. Both phylogenetic clustering and compartmental modelling analysis were performed based on the dominating viral variant (B.1-C15324T; 60% of all cases). Here we show that transmissions on the city population level are driven by the socioeconomically weaker and highly mobile groups. Simulated vaccination scenarios showed that vaccination of a third of the population at 90% efficacy prioritising the latter groups would induce a stronger preventive effect compared to vaccinating exclusively senior population groups first. Our analysis accounts for both social interaction and mobility on the basis of molecularly related cases, thereby providing high confidence estimates of the underlying epidemic dynamics that may readily be translatable to other municipal areas.


2005 ◽  
Vol 26 (2) ◽  
pp. 495-505 ◽  
Author(s):  
Guang Zhao Zeng ◽  
Lan Sun Chen ◽  
Li Hua Sun

1994 ◽  
Vol 112 (3) ◽  
pp. 579-594 ◽  
Author(s):  
E. Massad ◽  
M. Nascimento Burattini ◽  
R. S. De Azevedo Neto ◽  
Hyun Mo Yang ◽  
F. A. B. Coutinho ◽  
...  

SUMMARYA mixed vaccination strategy against rubella is proposed. We describe how the vaccination strategy was designed with the help of mathematical techniques. The strategy was designed for application in a non-immunized community of the State of São Paulo, Brazil, and was implemented by local health authorities in 1992. This strategy comprises a pulse vaccination campaign, covering the age interval between 1 and 10 years, followed by the introduction of the vaccine in the immunization calendar at 15 months of age. The expected impact of the proposed strategy is discussed.


2018 ◽  
Vol 23 (4) ◽  
pp. 457-474 ◽  
Author(s):  
Guruprasad Samantaa ◽  
Shyam Pada Bera

In this paper, we have considered a dynamical model of Chlamydia disease with varying total population size, bilinear incidence rate, and pulse vaccination strategy in a random environment. It has been shown that the Chlamydia epidemic model has global positive solutions and, under some conditions, it admits a unique positive periodic disease-free solution, which is globally exponentially stable in mean square. We have defined two positive numbers R1 and R2 (< R1). It is proved that the susceptible population will be persistent in the mean and the disease will be going to extinct if R1 < 1 and the susceptible population as well as the disease will be weakly persistent in the mean if R2 > 1. Our analytical findings are explained through numerical simulation, which show the reliability of our model from the epidemiological point of view.


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