ABCD Rule Implementation for the Skin Melanoma Assesment – A Study

2019 ◽  
Author(s):  
V. Rajinikanth ◽  
N. Sri Madhava Raja ◽  
S. Arunmozhi
Keyword(s):  
Skin Melanoma ◽  
Abcd Rule ◽  
Rule Implementation

Pigment Cell Skin Neoplasms in Children and Adolescents: Searching Skin Melanoma Diagnostic Markers

2016 ◽  
Vol 3 (1) ◽  
pp. 16-23
Author(s):  
G.M. Volgareva ◽  
◽  
A.V. Lebedeva ◽  
V.G. Polyakov ◽  
◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Pigment Cell ◽  
Skin Neoplasms ◽  
Diagnostic Markers ◽  
Skin Melanoma

Pigment Cell Skin Neoplasms in Children and Adolescents: Searching Skin Melanoma Diagnostic Markers

2016 ◽  
Vol 3 (1) ◽  
pp. 16-23
Author(s):  
G. M. Volgareva ◽  
A. V. Lebedeva ◽  
V. G. Polyakov
Keyword(s):  
Children And Adolescents ◽  
Pigment Cell ◽  
Skin Neoplasms ◽  
Diagnostic Markers ◽  
Skin Melanoma

SKIN MELANOMA INCIDENCE IN WORKERS OCUPATIONALLY EXPOSED TO IONIZING RADIATION OVER A PROLONGED PERIOD

2019 ◽  
Vol 65 (3) ◽  
pp. 441-446
Author(s):  
Valentina Rybkina ◽  
Tamara Azizova ◽  
Yevgeniya Grigoreva
Keyword(s):  
Ionizing Radiation ◽  
Gamma Rays ◽  
Disease Risk ◽  
Incidence Rates ◽  
Study Cohort ◽  
Calendar Period ◽  
Skin Melanoma ◽  
Melanoma Incidence ◽  
Occupationally Exposed

Purpose of the study. The study is aimed to investigate skin melanoma incidence in workers occupationally exposed to radiation over a prolonged period. Materials and methods. Skin melanoma incidence was studied in a cohort of workers first employed at nuclear facility Mayak Production Association (PA) between 1948 and 1982 who had been followed up till 31.12.2013 (22,377 individuals). Mean cumulative doses from external gamma-rays over the whole follow-up period were 0.54±0.001 Sv in males and 0.44±0.002 Sv in females. Incident rates for skin melanoma were analyzed by sex, attained age, calendar period of diagnostics and radiation dose using worldwide standard and the direct standardization technique. Results. 60 skin melanoma cases (37 in males and 23 in females) were registered in the study cohort over the whole follow-up period. The standardized skin melanoma incident rate was 8.51±1.46 in males and 8.78±2.27 in females per 100000 workers revealing statistically higher rates compared to corresponding rates for general populations of the Russian Federation, Urals Federal District and Chelyabinsk region. Skin melanoma incidence was significantly increased in the period of 1994 - 2013 as compared to the period of 1974 - 1993. Skin melanoma incidence excess in females was greater than that for males. Skin melanoma incidence increment in females was mostly driven by modifications of disease occurrence risk while in males it was driven by a combined effect of age pattern modifications in the study cohort and increase of disease risk. Conclusions. Skin melanoma incidence rates in the cohort of workers occupationally exposed to ionizing radiation over a prolonged period were associated with sex and attained age workers and the calendar period of diagnostics. No significant association of skin melanoma incidence with dose from external gamma-rays was observed. A significantly increasing trend was observed for skin melanoma incidence by the end of the follow-up in both males and females.

CYTOLOGICAL DIAGNOSIS AS A METHOD OF SCREENING OF PRE-MALIGNANT MELANOCYTIC TUMORS AND EARLY FORMS OF SKIN MELANOMA

2018 ◽  
Vol 64 (3) ◽  
pp. 384-387
Author(s):  
Viktor Novik ◽  
D. Dreval
Keyword(s):  
Laser Therapy ◽  
Histological Examination ◽  
Clinical Data ◽  
Surgical Excision ◽  
Cytological Diagnosis ◽  
Skin Melanoma ◽  
Cytological Examination ◽  
Melanocytic Tumors ◽  
Quality Character ◽  
Atypical Nevi

Cytohistological comparisons to the account of the clinical data and revision of cytological and histological preparations on a material received from 21 patients are made. Cytomorphological features of juvenile nevi (Spitz-nevus, Reed-nevus), dysplastic and atypical nevi and early forms of melanoma are described. The establishment at cytological examination of good-quality character of melanocytic defeats at the account of the clinical data could be the basis for appointment laser therapy. At revealing of atypical melanocytes in cytological preparations patients should be referred to specialized oncological institutions for surgical excision of tumor with the subsequent histological examination. Thus cytological examination could be used in dermatological practice as a method of screening pre-malignant melanocytic tumors and skin melanoma.

Transdermal delivery of Cu-doped polydopamine using microneedles for photothermal and chemodynamic synergistic therapy against skin melanoma

2021 ◽  
pp. 130790
Author(s):  
Gao Song ◽  
Yanfang Sun ◽  
Tianqi Liu ◽  
Xueya Zhang ◽  
Zhiyong Zeng ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Skin Melanoma

Extraction of Skin Melanoma Section using Levelset Segmentation ─ An Analysis

2020 ◽  
Author(s):  
P. Monica ◽  
K. Priyanga ◽  
S. Keerthana ◽  
N. Sri Madhava Raja ◽  
S. Arunmozhi
Keyword(s):  
Skin Melanoma

scholarly journals In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers

2021 ◽  
Vol 22 (13) ◽  
pp. 7238
Author(s):  
Wojciech Snoch ◽  
Dawid Wnuk ◽  
Tomasz Witko ◽  
Jakub Staroń ◽  
Andrzej J. Bojarski ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Prostate Cancer Cell ◽  
Fatty Acid Esters ◽  
Skin Melanoma ◽  
Cancer Treatments ◽  
Sugar Esters ◽  
Hydroxylated Fatty Acids ◽  
Ic50 Values ◽  
Metastatic Process ◽  
Acid Esters

Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE’s hydrophobic chains can influence their cytotoxicity against human skin melanoma and prostate cancer cell lines. The compound’s cytotoxicity was determined by an MTT assay, which followed an assessment of SFAEs’ potential metastatic properties in concentrations below IC50 values. Despite relatively high IC50 values (63.3–1737.6 μM) of the newly synthesized SFAE, they can compete with other sugar esters already described in the literature. The chosen bioactives caused low polymerization of microtubules and the depolymerization of actin filaments in nontoxic levels, which suggest an apoptotic rather than metastatic process. Altogether, cancer cells showed no propensity for metastasis after treating them with SFAE. They confirmed that lactose-based compounds seem the most promising surfactants among tested sugar esters. This manuscript creates a benchmark for creation of novel anticancer agents based on 3-hydroxylated fatty acids of bacterial origin.

Skin Melanoma Detection in Microscopic Images Using HMM-Based Asymmetric Analysis and Expectation Maximization

2021 ◽  
pp. 1-1
Author(s):  
Rozita Rastghalam ◽  
Habibollah Danyali ◽  
Mohammad Sadegh Helfroush ◽  
M. Emre Celebi ◽  
Mojgan Mokhtari
Keyword(s):  
Expectation Maximization ◽  
Skin Melanoma ◽  
Microscopic Images ◽  
Melanoma Detection
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