The Effects of Thymus Plant Extracts on Single Breast Cancer Cell Morphology in the Microfluidic Channel

2018 ◽  
Author(s):  
Mohd Ridzuan Ahmad ◽  
Muhammad Asraf Mansor ◽  
Maryam Alsadat Rad ◽  
Alan Soo-Beng Khoo ◽  
Munirah Ahmad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Plant Extracts ◽  
Cell Morphology ◽  
Microfluidic Channel

scholarly journals Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis

2011 ◽  
Vol 22 (3) ◽  
pp. 327-341 ◽  
Author(s):  
Nicholas O. Deakin ◽  
Christopher E. Turner
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Morphology ◽  
Molecular Mechanisms ◽  
Adhesion Formation ◽  
Three Dimensional ◽  
Rho Kinase ◽  
Adaptor Protein ◽  
Metastatic Tumor

Individual metastatic tumor cells exhibit two interconvertible modes of cell motility during tissue invasion that are classified as either mesenchymal or amoeboid. The molecular mechanisms by which invasive breast cancer cells regulate this migratory plasticity have yet to be fully elucidated. Herein we show that the focal adhesion adaptor protein, paxillin, and the closely related Hic-5 have distinct and unique roles in the regulation of breast cancer cell lung metastasis by modulating cell morphology and cell invasion through three-dimensional extracellular matrices (3D ECMs). Cells depleted of paxillin by RNA interference displayed a highly elongated mesenchymal morphology, whereas Hic-5 knockdown induced an amoeboid phenotype with both cell populations exhibiting reduced plasticity, migration persistence, and velocity through 3D ECM environments. In evaluating associated signaling pathways, we determined that Rac1 activity was increased in cells devoid of paxillin whereas Hic-5 silencing resulted in elevated RhoA activity and associated Rho kinase–induced nonmuscle myosin II activity. Hic-5 was essential for adhesion formation in 3D ECMs, and analysis of adhesion dynamics and lifetime identified paxillin as a key regulator of 3D adhesion assembly, stabilization, and disassembly.

scholarly journals A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration

2015 ◽  
Vol 9 (6) ◽  
pp. 483-494 ◽  
Author(s):  
Rania Al-Mahdi ◽  
Nouf Babteen ◽  
Kiruthikah Thillai ◽  
Mark Holt ◽  
Bjarne Johansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Morphology ◽  
Mapk Kinase ◽  
And Migration

scholarly journals Anticancer activities and safety evaluation of selected Kenyan plant extracts against breast cancer cell lines

2018 ◽  
Vol 10 (2) ◽  
pp. 21-26
Author(s):  
Jared M. Onyancha ◽  
Nicholas K. Gikonyo ◽  
Sabina W. Wachira ◽  
Peter G. Mwitari ◽  
Michael M. Gicheru
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Plant Extracts ◽  
Safety Evaluation ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Anticancer Activities

scholarly journals AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology

2007 ◽  
Vol 212 (3) ◽  
pp. 655-665 ◽  
Author(s):  
Richard I. Near ◽  
Yujun Zhang ◽  
Anthony Makkinje ◽  
Pierre Vanden Borre ◽  
Adam Lerner
Keyword(s):  
Breast Cancer ◽  
Cyclin D1 ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Morphology ◽  
Promoter Activation

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

2009 ◽  
Vol 8 (7) ◽  
pp. 2027-2035 ◽  
Author(s):  
Erin M. Goldblatt ◽  
Erin R. Gentry ◽  
Melanie J. Fox ◽  
Sergei M. Gryaznov ◽  
Changyu Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Morphology
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