The article analyzes the influence of external factors on the settlement of the situation in Syria. The author focuses on Syria's interaction with such countries as Russia, the United States, Turkey and Iran. The author provides a comparative description of the goals and objectives of these countries to resolve the situation, as well as examples of the interest of these states in resolving the conflict. Political science techniques such as event analysis, system and sociological analysis, and modeling were used in dealing with the paper topic. The author concludes that external factors in the settlement of the situation in Syria can be, both positive and negative, depending on the development of further events in the country, manifestations of opposition forces, as well as possible conflict situations between the third countries themselves.