Free-Space Operating Microwave Imaging Device for Bone Lesion Detection: A Phantom Investigation

This paper demonstrates the outcomes of a feasibility study of a microwave imaging procedure based on the Huygens principle for bone lesion detection. This study has been performed using a dedicated phantom and validated through measurements in the frequency range of 1–3 GHz using one receiving and one transmitting antenna in free space. Specifically, a multilayered bone phantom, which is comprised of cortical bone and bone marrow layers, was fabricated. The identification of the lesion’s presence in different bone layers was performed on images that were derived after processing through Huygens’ principle, the S21 signals measured inside an anechoic chamber in multi-bistatic fashion. The quantification of the obtained images was carried out by introducing parameters such as the resolution and signal-to-clutter ratio (SCR). The impact of different frequencies and bandwidths (in the 1–3 GHz range) in lesion detection was investigated. The findings showed that the frequency range of 1.5–2.5 GHz offered the best resolution (1.1 cm) and SCR (2.22 on a linear scale). Subtraction between S21 obtained using two slightly displaced transmitting positions was employed to remove the artefacts; the best artefact removal was obtained when the spatial displacement was approximately of the same magnitude as the dimension of the lesion.

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Empirical Assessment of Breast Lesion Detection Capability Through an Innovative Microwave Imaging Device

2021 15th European Conference on Antennas and Propagation (EuCAP) ◽

10.23919/eucap51087.2021.9411432 ◽

2021 ◽

Author(s):

Lorenzo Sani ◽

Alessandro Vispa ◽

Navid Ghavami ◽

Riccardo Loretoni ◽

Michele Duranti ◽

...

Keyword(s):

Breast Lesion ◽

Microwave Imaging ◽

Lesion Detection ◽

Detection Capability ◽

Imaging Device ◽

Empirical Assessment

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Diagnostic Value of Whole-Body MRI Short Protocols in Bone Lesion Detection in Multiple Myeloma Patients

Diagnostics ◽

10.3390/diagnostics11061053 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1053

Author(s):

Davide Ippolito ◽

Teresa Giandola ◽

Cesare Maino ◽

Davide Gandola ◽

Maria Ragusi ◽

...

Keyword(s):

Multiple Myeloma ◽

Bone Marrow Involvement ◽

Bone Lesion ◽

Diagnostic Value ◽

Lesion Detection ◽

Lower Limbs ◽

Whole Body ◽

Bone Lesions ◽

Whole Body Mri ◽

Mri Protocol

The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number (<5, 5–20, and >20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.

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