A High Sensitivity Transparent Ultrasound Transducer Based on PMN-PT for Ultrasound and Photoacoustic Imaging

2021 ◽  
Vol 5 (11) ◽  
pp. 1-4
Author(s):  
Haoyang Chen ◽  
Shubham Mirg ◽  
Mohamed Osman ◽  
Sumit Agrawal ◽  
Jiacheng Cai ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Ultrasound Transducer

scholarly journals Photoacoustic reporter genes for noninvasive molecular imaging and theranostics

2020 ◽  
Vol 13 (03) ◽  
pp. 2030005
Author(s):  
Zhao Lei ◽  
Yun Zeng ◽  
Xiaofen Zhang ◽  
Xiaoyong Wang ◽  
Gang Liu
Keyword(s):  
Molecular Imaging ◽  
Fluorescent Proteins ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Reporter Genes ◽  
Biological Processes ◽  
Deep Tissue ◽  
Potential Applications ◽  
Improved Performance

Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene’s expression driven by disease-specific enhancers/promoters. Here, we present a brief overview of recent studies about the existing photoacoustic reporter genes (RGs) for noninvasive molecular imaging, such as the pigment enzyme reporters, fluorescent proteins and chromoproteins, photoswitchable proteins, including their properties and potential applications in theranostics. Furthermore, the challenges that PAI RGs face when applied to the clinical studies are also examined.

Resonant optical ultrasound transducer (ROUT) arrays for high resolution photoacoustic imaging

2006 ◽  
Author(s):  
M. O'Donnell ◽  
S. Ashkenazi ◽  
L. J. Guo ◽  
C. Y. Chao ◽  
W. Y. Fung ◽  
...  
Keyword(s):  
High Resolution ◽  
Photoacoustic Imaging ◽  
Ultrasound Transducer

scholarly journals Ring Ultrasound Transducer Based Miniaturized Photoacoustic Imaging System

2018 ◽  
Author(s):  
Ajay Dangi ◽  
Sumit Agrawal ◽  
Jedidiah Lieberknecht ◽  
Jason Zhang ◽  
Sri-Rajasekhar Kothapalli
Keyword(s):  
Imaging System ◽  
Photoacoustic Imaging ◽  
Ultrasound Transducer

Transparent flexible piezoelectric ultrasound transducer for photoacoustic imaging system

2021 ◽  
pp. 1-1
Author(s):  
Ya-Han Liu ◽  
Li-Xiang Chen ◽  
Chih-Ying Li ◽  
Fu-Sung Lin ◽  
Hsin-Yi Su ◽  
...  
Keyword(s):  
Imaging System ◽  
Photoacoustic Imaging ◽  
Ultrasound Transducer

Acceptor Engineering of Small Molecule Fluorophores for NIR-II Fluorescent and NIR-I Photoacoustic Imaging

2021 ◽  
Author(s):  
Yaxi Li ◽  
Hongli Zhou ◽  
Renzhe Bi ◽  
Xiuting Li ◽  
Menglei Zha ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Small Molecule ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Infrared Window

Fluorescence imaging in the second near-infrared window (NIR-II) has been an emerging technique in diverse in vivo applications with high sensitivity/resolution and deep tissue penetration. To date, the designing principle...

scholarly journals Polymer microring resonators for high-sensitivity and wideband photoacoustic imaging

2009 ◽  
Vol 56 (11) ◽  
pp. 2482-2491 ◽  
Author(s):  
S.-L. Chen ◽  
S.-W. Huang ◽  
T. Ling ◽  
S. Ashkenazi ◽  
L. Guo
Keyword(s):  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Microring Resonators

scholarly journals Photoacoustic imaging resolves species-specific differences in haemoglobin concentration and oxygenation

2020 ◽  
Author(s):  
Lina Hacker ◽  
Joanna Brunker ◽  
Ewan St. John Smith ◽  
Isabel Quiros-Gonzalez ◽  
Sarah E. Bohndiek
Keyword(s):  
Photoacoustic Imaging ◽  
Haemoglobin Concentration ◽  
Oxygen Affinity ◽  
High Sensitivity ◽  
Blood Parameters ◽  
Validation Data ◽  
Rat Blood ◽  
Species Specific ◽  
Dissociation Curves

AbstractIntroductionPhotoacoustic imaging (PAI) enables the detection of blood haemoglobin (HB) concentration and oxygenation (SO2) with high contrast and resolution. To date, the relationship between photoacoustically determined total Haemoglobin (THbMSOT) and oxygen saturation (SO2) biomarkers and the underlying biochemical blood parameters has yet to be established. We sought to explore these relationships in a species-specific manner.MethodsExperiments were performed in vitro using tissue-mimicking agar phantoms. Blood was extracted from mouse, rat, human and naked mole-rat (Heterocephalus glaber), anticoagulated in EDTA and measured within 48 hours. THbMSOT and SO2MSOT were measured using a commercial photoacoustic tomography system (InVision 128, iThera Medical GmBH). Biochemical blood parameters such as haemoglobin concentration (HB, g/dL), haematocrit (HCT, %) and red blood cell count (RBC, μL-1) were assessed using a haematology analyser (Mythic 18 Vet, Woodley Equipment).ResultsA significant correlation was observed between THbMSOT and biochemical HB, HCT and RBC in mouse and rat blood. Moreover, PAI accurately recapitulated inter-species variations in HB and HCT between mouse and rat blood and resolved differences in the oxygen dissociation curves between human, mouse and rat. With these validation data in hand, we applied PAI to studies of blood obtained from naked mole-rats and could confirm the high oxygen affinity of this species in comparison to other rodents of similar size.ConclusionIn summary, our results demonstrate the high sensitivity of photoacoustically determined biomarkers towards species-specific variations in vitro.

MOPA fiber laser for photoacoustic imaging using arrayed ultrasound transducer

2017 ◽  
Author(s):  
Yong-Jae Lee ◽  
Jun-Tae Ahn ◽  
Eun-Ju Jeong ◽  
Hyun-Woo Song ◽  
Chang-Geun Ahn ◽  
...  
Keyword(s):  
Fiber Laser ◽  
Photoacoustic Imaging ◽  
Ultrasound Transducer
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