Effect of body mass index, body composition, age and menopause on total body bone mineral density in Indian women

Author(s):  
M.S. Holi ◽  
S. Radhakrishnan
2016 ◽  
Vol 39 (4) ◽  
pp. 582-599 ◽  
Author(s):  
Demetrius A. Abshire ◽  
Debra K. Moser ◽  
Jody L. Clasey ◽  
Misook L. Chung ◽  
Susan J. Pressler ◽  
...  

The purpose of this study was to examine associations among bone mineral density, osteopenia/osteoporosis, body mass index (BMI), and body composition in patients with heart failure (HF). A total of 119 patients (age = 61 ± 12 years, 65% male) underwent dual-energy X-ray absorptiometry scans to determine bone mineral density and body composition. In multivariable linear regressions, BMI, relative skeletal muscle index (RSMI), and mineral-free lean mass were positively associated with total body bone mineral density. Mineral-free lean mass was most strongly associated with bone mineral density (β = .398). In multivariable logistic regressions, higher BMI, RSMI, and mineral-free lean mass were associated with lower odds for osteopenia/osteoporosis. Fat mass was not associated with total body bone mineral density or osteopenia/osteoporosis. These results suggest that muscle mass may be the important component of body mass associated with bone mineral density in patients with HF.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Julia Clarke ◽  
Hugo Peyre ◽  
Marianne Alison ◽  
Anne Bargiacchi ◽  
Coline Stordeur ◽  
...  

Abstract Background Early-onset anorexia nervosa (EO-AN) represents a significant clinical burden to paediatric and mental health services. The impact of EO-AN on bone mineral abnormalities has not been thoroughly investigated due to inadequate control for pubertal status. In this study, we investigated bone mineral abnormalities in girls with EO-AN regardless of pubertal development stage. Method We conducted a cross-sectional study of 67 girls with EO-AN (median age = 12.4 [10.9–13.7 years]) after a median duration of disease of 1.3 [0.6–2.0] years, and 67 healthy age-, sex-, pubertal status- matched control subjects. We compared relevant bone mineral parameters between groups: the total body bone mineral density [TB-BMD], the lumbar spine BMD [LS-BMD], the total body bone mineral content [TB-BMC] and the ratio of the TB-BMC to lean body mass [TB-BMC/LBM]. Results TB-BMD, TB-BMC, LS-BMD and TB-BMC/LBM were all significantly lower in patients with AN compared to controls. In the EO-AN group, older age, later pubertal stages and higher lean body mass were associated with higher TB-BMC, TB-BMD, and LS-BMD values. Discussion Girls with EO-AN displayed deficits in bone mineral content and density after adjustment for pubertal maturation. Age, higher pubertal stage and lean body mass were identified as determinants of bone maturation in the clinical population of patients with EO-AN. Bone health should be promoted in patients, specifically in those with an onset of disorder before 14 years old and with a delayed puberty.


1992 ◽  
Vol 82 (4) ◽  
pp. 429-432 ◽  
Author(s):  
J. E. Compston ◽  
M. A. Laskey ◽  
P. I. Croucher ◽  
A. Coxon ◽  
S. Kreitzman

1. Total body areal bone mineral density was measured by dual-energy X-ray absorptiometry in eight women before and 10 weeks after a very-low-calorie diet [405 kcal (1701 kJ)/day]. 2. The mean weight loss of 15.6 kg was accompanied by a statistically significant reduction in total body bone mineral density from 1.205 ± 0.056 to 1.175 ± 0.058 g/cm2 (mean ± sd, P < 0.005). 3. After cessation of the diet, weight gradually increased and by 10 months was similar to baseline values. Total body bone mineral density also increased after stopping the diet and mean values obtained 10 months after the diet did not differ significantly from initial values. Throughout the study total body bone mineral density values in all subjects were well within the range reported for normal subjects. 4. These data indicate that diet-induced weight loss is associated with rapid bone loss, subsequent weight gain being accompanied by increases in bone mass. Further studies are required to establish the clinical significance of these findings and, in particular, the skeletal distribution of bone loss.


Bone ◽  
2007 ◽  
Vol 40 (6) ◽  
pp. S49-S50
Author(s):  
M.J. Henwood ◽  
K. Blake ◽  
L.A. Binkovitz ◽  
M. Nunes ◽  
S.A. Bowden ◽  
...  

1997 ◽  
Vol 40 (11) ◽  
pp. 1967-1975 ◽  
Author(s):  
Carol J. Henderson ◽  
Bonny L. Specker ◽  
Rosa I. Sierra ◽  
Robert W. Wilmott ◽  
Daniel J. Lovell ◽  
...  

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