scholarly journals Bifunctional silica nanoparticles for the exploration of Pseudomonas aeruginosa biofilm

Author(s):  
L. Mauline ◽  
M. Gressier ◽  
P. Hammer ◽  
S. J. L. Ribeiro ◽  
J. M. A. Caiut ◽  
...  
2021 ◽  
pp. 088532822110038
Author(s):  
Mohammad Yousef Memar ◽  
Mina Yekani ◽  
Hadi Ghanbari ◽  
Edris Nabizadeh ◽  
Sepideh Zununi Vahed ◽  
...  

The aims of the present study were the determination of antimicrobial and antibiofilm effects of meropenem-loaded mesoporous silica nanoparticles (MSNs) on carbapenem resistant Pseudomonas aeruginosa ( P. aeruginosa) and cytotoxicity properties in vitro. The meropenem-loaded MSNs had shown antibacterial and biofilm inhibitory activities on all isolates at different levels lower than MICs and BICs of meropenem. The viability of HC-04 cells treated with serial concentrations as MICs and BICs of meropenem-loaded MSNs was 92–100%. According to the obtained results, meropenem-loaded MSNs display the significant antibacterial and antibiofilm effects against carbapenem resistant and biofilm forming P. aeruginosa and low cell toxicity in vitro. Then, the prepared system can be an appropriate option for the delivery of carbapenem for further evaluation in vivo assays.


2019 ◽  
Vol 18 (8) ◽  
pp. 1936-1943
Author(s):  
Xiu-mei DONG ◽  
Jing TAO ◽  
Ting-ting LI ◽  
Ping ZHANG ◽  
Yan ZHU ◽  
...  

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Mathilde Delaval ◽  
Sonja Boland ◽  
Brigitte Solhonne ◽  
Marie-Anne Nicola ◽  
Stéphane Mornet ◽  
...  

2007 ◽  
Vol 177 (4S) ◽  
pp. 102-103
Author(s):  
Shinya Uehara ◽  
Koichi Monden ◽  
Koichiro Wada ◽  
Ayano Ishii ◽  
Reiko Kariyama ◽  
...  

1968 ◽  
Vol 97 (2) ◽  
pp. 149-153 ◽  
Author(s):  
W. V. Shellow

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