A high-speed and high-precision Winner-Select-Output (WSO) ASIC

Author(s):  
Haiming Yu ◽  
R.S. Miyaaoka ◽  
T.K. Lewellen
Keyword(s):  
2021 ◽  
pp. 002029402110022
Author(s):  
Xiaohua Zhou ◽  
Jianbin Zheng ◽  
Xiaoming Wang ◽  
Wenda Niu ◽  
Tongjian Guo

High-speed scanning is a huge challenge to the motion control of step-scanning gene sequencing stage. The stage should achieve high-precision position stability with minimal settling time for each step. The existing step-scanning scheme usually bases on fixed-step motion control, which has limited means to reduce the time cost of approaching the desired position and keeping high-precision position stability. In this work, we focus on shortening the settling time of stepping motion and propose a novel variable step control method to increase the scanning speed of gene sequencing stage. Specifically, the variable step control stabilizes the stage at any position in a steady-state interval rather than the desired position on each step, so that reduces the settling time. The resulting step-length error is compensated in the next acceleration and deceleration process of stepping to avoid the accumulation of errors. We explicitly described the working process of the step-scanning gene sequencer and designed the PID control structure used in the variable step control for the gene sequencing stage. The simulation was performed to check the performance and stability of the variable step control. Under the conditions of the variable step control where the IMA6000 gene sequencer prototype was evaluated extensively. The experimental results show that the real gene sequencer can step 1.54 mm in 50 ms period, and maintain a high-precision stable state less than 30 nm standard deviation in the following 10 ms period. The proposed method performs well on the gene sequencing stage.


Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S97
Author(s):  
J. Bell ◽  
Y. Huang ◽  
S. Yung ◽  
H. Qazi ◽  
C. Hernandez ◽  
...  

Author(s):  
S. Tiguntsev

In classical physics, time is considered absolute. It is believed that all processes, regardless of their complexity, do not affect the flow of time The theory of relativity determines that the flow of time for bodies depends both on the speed of movement of bodies and on the magnitude of the gravitational potential. It is believed that time in space orbit passes slower due to the high speed of the spacecraft, and faster due to the lower gravitational potential than on the surface of the Earth. Currently, the dependence of time on the magnitude of the gravitational potential and velocity (relativistic effect) is taken into account in global positioning systems. However, studying the relativistic effect, scientists have made a wrong interpretation of the difference between the clock frequency of an orbiting satellite and the clock frequency on the Earth's surface. All further studies to explain the relativistic effect were carried out according to a similar scenario, that is, only the difference in clock frequencies under conditions of different gravitational potentials was investigated. While conducting theoretical research, I found that the frequency of the signal changes along the way from the satellite to the receiver due to the influence of Earth's gravity. It was found that the readings of two high-precision clocks located at different heights will not differ after any period of time, that is, it is shown that the flow of time does not depend on the gravitational potential. It is proposed to conduct full-scale experiments, during which some high-precision clocks are sent aboard the space station, while others remain in the laboratory on the surface of the earth. It is expected that the readings of the satellite clock will be absolutely identical to the readings of the clock in the Earth laboratory.


2011 ◽  
Vol 175 ◽  
pp. 177-182
Author(s):  
Ya Dong Gong ◽  
Yue Ming Liu ◽  
Ting Chao Han ◽  
Jun Cheng

The application of the wheel used in super-high speed point (SHSP) grinding is introduced in detail, depicting the applied rang of the wheel, through designing the wheel body and the layer of CBN in the wheel. The designed principle is inferred according to the specific shape, the grinding productivity is analyzed in the course grinding zone and the finished grinding zone, introducing the angle of course grinding zone, which affects the grinding parameters in SHSP grinding, the value of the angle is designed to be suited to the point grinding, and manufacturing the wheel, introducing the changed state of chip flowing grinding used in the new wheel, the micro-surface of the wheel is observed through microscope, whose the ratio of air hole and the layer of CBN are analyzed, simulating the wear trend of the new wheel, the conclusions about super hard abrasives and wearing are drawn at last, the application of SHSP grinding is related to designing and manufacturing of the wheel, which provides the equipment for realizing high precision and productivity processing and offers the referred basis for the theoretical research.


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