In vivo blood compatibility of titanium oxide film coated artificial heart valves prepared by plasma immersion ion implantation and deposition

This study has examined a range of methods of studying the calcification process in bovine pericardial and polyurethane biomaterials. The calcification methods include static and dynamic, in vitro and in vivo tests. The analytical methods include measurement of depletion rates of calcium and phosphate from in vitro calcifying solutions, analysis of tissue contents of calcium, histological staining of tissue sections for calcium, X-ray elemental analysis, by scanning electron microscopy, of calcium and phosphorus distributions over valve leaflets calcified in vitro under dynamic conditions. Bovine pericardium, in all test settings, calcified to a much greater degree than polyurethane biomaterials. Polyurethane extracts calcified to a greater degree than bulk polyurethanes. The test protocol used allows progress through increasily demanding calcification tests, with the possibility of eliminating unsuitable materials with tests of limited complexity and expense.

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Investigation of Blood Compatibility of Titanium Oxide Film Doped with Tantalum by Sputtering Deposition

Processing and Fabrication of Advanced Materials VIII ◽

10.1142/9789812811431_0040 ◽

2001 ◽

Author(s):

Nan Huang ◽

Junying Chen ◽

Ping Yang ◽

Yongxiang Leng ◽

Hong Sun ◽

...

Keyword(s):

Oxide Film ◽

Titanium Oxide ◽

Blood Compatibility ◽

Titanium Oxide Film ◽

Sputtering Deposition

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Improving Blood Compatibility of Cardiovascular Devices by Surface Modification

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.342-343.801 ◽

2007 ◽

Vol 342-343 ◽

pp. 801-804 ◽

Cited By ~ 2

Author(s):

Nan Huang ◽

Ping Yang ◽

Yong Xiang Leng ◽

Jun Ying Chen ◽

Jin Wang ◽

...

Keyword(s):

Surface Modification ◽

Artificial Heart ◽

Heart Valves ◽

Blood Compatibility ◽

Artificial Heart Valve ◽

Cardiovascular Devices ◽

Inorganic Films ◽

Artificial Heart Valves ◽

Plasma Grafting ◽

Circulation Tube

This paper presents recent activities on the surface modification of blood contacting biomaterials and devices in the author’s laboratory. Surface coating of inorganic films on materials for artificial heart valves, ventricular pumps and coronary stents, such as titanium, stainless steel and low temperature isotropic pryolitc carbon, etc, shows a significant improvement in the anticoagulation behavior. Further, the formation of functional groups such as hydroxyl or amino groups and the binding of biomolecules as well as seeding of endothelial cell shows the promise of biomimetic surface formation. Plasma grafting on materials for artificial heart valve sewing cuff, extracorporeal circulation tube, etc, such as PET, PU, PVC polymers, revealed a significant improvement of anti-platelet adhesion as well as anti-bacterial properties.

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Artificial Heart Valves: Improved Blood Compatibility by PECVD a-SiC:H Coating

Artificial Organs ◽

10.1111/j.1525-1594.1990.tb02967.x ◽

1990 ◽

Vol 14 (4) ◽

pp. 260-269 ◽

Cited By ~ 63

Author(s):

A. Bolz ◽

M. Schaldach

Keyword(s):

Artificial Heart ◽

Heart Valves ◽

Blood Compatibility ◽

Artificial Heart Valves

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A Study on the Interface between Oxide Film on the Titanium Surface and Bone Tissue

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.342-343.545 ◽

2007 ◽

Vol 342-343 ◽

pp. 545-548

Author(s):

Li Ping Wang ◽

Bang Cheng Yang ◽

Ji Yong Chen ◽

Xing Dong Zhang

Keyword(s):

Heat Treatment ◽

Oxide Film ◽

Titanium Oxide ◽

Titanium Surface ◽

The Other ◽

Apatite Formation ◽

Titanium Oxide Film ◽

Heat Treated

The bioactivities of titanium oxide film on titanium surface received from different chemical treatment methods were studied in SBF in vitro and mechanically and histologically investigated in vivo. Three groups of titanium specimens were prepared: untreated titanium(S), acid-alkali treated titanium (H), and acid-alkali and heat-treated titanium(X). The oxide film of X surface resulted in more apatite formation and significantly higher strength of the interface between the samples and bone than those of the other titanium groups. The surface of the acid-alkali treated titanium and that further treated by heat treatment had higher bioactivity and stronger bone-bonding ability.

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