Improvement of blood compatibility of artificial heart valves via titanium oxide film coated on low temperature isotropic carbon

This paper presents recent activities on the surface modification of blood contacting biomaterials and devices in the author’s laboratory. Surface coating of inorganic films on materials for artificial heart valves, ventricular pumps and coronary stents, such as titanium, stainless steel and low temperature isotropic pryolitc carbon, etc, shows a significant improvement in the anticoagulation behavior. Further, the formation of functional groups such as hydroxyl or amino groups and the binding of biomolecules as well as seeding of endothelial cell shows the promise of biomimetic surface formation. Plasma grafting on materials for artificial heart valve sewing cuff, extracorporeal circulation tube, etc, such as PET, PU, PVC polymers, revealed a significant improvement of anti-platelet adhesion as well as anti-bacterial properties.

Download Full-text

Artificial Heart Valves: Improved Blood Compatibility by PECVD a-SiC:H Coating

Artificial Organs ◽

10.1111/j.1525-1594.1990.tb02967.x ◽

1990 ◽

Vol 14 (4) ◽

pp. 260-269 ◽

Cited By ~ 63

Author(s):

A. Bolz ◽

M. Schaldach

Keyword(s):

Artificial Heart ◽

Heart Valves ◽

Blood Compatibility ◽

Artificial Heart Valves

Download Full-text

Blood compatibility improvement of titanium oxide film modified by doping La2O3

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-009-3784-3 ◽

2009 ◽

Vol 20 (10) ◽

pp. 2019-2023 ◽

Cited By ~ 4

Author(s):

Lin Zhang ◽

Dihu Chen ◽

Keqiang Wang ◽

Fengmei Yu ◽

Zhanyun Huang ◽

...

Keyword(s):

Oxide Film ◽

Titanium Oxide ◽

Blood Compatibility ◽

Titanium Oxide Film

Download Full-text

Functionality of Ti-O Thin Films Doped by Phosphorus: Wettability, Semiconductor Performance and Blood Compatibility

Materials Science Forum ◽

10.4028/www.scientific.net/msf.610-613.1017 ◽

2009 ◽

Vol 610-613 ◽

pp. 1017-1021 ◽

Cited By ~ 4

Author(s):

Jin Biao Wang ◽

Ping Yang ◽

Gui Cai Li ◽

Zhong Hai Yang ◽

Yong Xiang Leng ◽

...

Keyword(s):

Oxide Film ◽

Titanium Oxide ◽

Photoelectron Spectroscopy ◽

High Performance ◽

Blood Compatibility ◽

Oxide Thin Film ◽

Titanium Oxide Film ◽

Rutile Structure ◽

X Ray ◽

Wafer Substrate

For an application as biomedical materials of high performance with a good biocompatibility, the Ti-O film on Si (110) wafer substrate has been synthesize by means of unbalance reactive magnetron sputtering method and modified by phosphorus ion implantation and succeeding vacuum annealing. X-ray diffraction (XRD) results indicated that such prepared Ti-O film had a rutile structure. X-ray photoelectron spectroscopy (XPS) analysis demonstrates the effect of P ion doping. The contact angle test and sheet resistance results showed that titanium oxide film and phosphorus-doped titanium oxide film became more hydrophilic and higher conductance after annealing. The morphology and roughness of the surface have been investigated using SEM. Antithrombotic property of the titanium oxide thin film was examined by platelet adhesion tests. The results showed that the undoped Ti-O films and the P implant and annealing at 900 °C Ti-O film had good blood compatibility.

Download Full-text