scholarly journals Evaluation of the packaging and encapsulation reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA): Implications for long term functionality

2011 ◽  
Author(s):  
A. Sharma ◽  
L. Rieth ◽  
P. Tathireddy ◽  
R. Harrison ◽  
H. Oppermann ◽  
...  
Keyword(s):  
Electrode Array ◽  
Fully Integrated

scholarly journals Long term in vitro stability of fully integrated wireless neural interfaces based on Utah slant electrode array

2010 ◽  
Vol 96 (7) ◽  
pp. 073702 ◽  
Author(s):  
Asha Sharma ◽  
Loren Rieth ◽  
Prashant Tathireddy ◽  
Reid Harrison ◽  
Florian Solzbacher
Keyword(s):  
Electrode Array ◽  
Neural Interfaces ◽  
Fully Integrated ◽  
In Vitro Stability

International Real Estate Review

2016 ◽  
Vol 19 (3) ◽  
pp. 371-409
Author(s):  
Yuen-Meng Wong ◽  
Keyword(s):  
Real Estate ◽  
Interest Rates ◽  
Turn Of The Millennium ◽  
Market Returns ◽  
Stock Market Returns ◽  
Fully Integrated ◽  
Empirical Tests ◽  
Market Capitalisation ◽  
Domestic Stock

Real estate investment trusts (REITs) are a niche alternative investment class. Since their introduction in Asia at the turn of the millennium, the REIT market in the region has experienced phenomenal growth. In particular, the Malaysia REIT (M-REIT ) market capitalisation has seen a spectacular growth of close to 20 folds from its inception in 2005 until the end of 2013. This paper chronicles the development of the M-REIT market which is rather unique as it provides a common platform for the existence of both conventional and Islamic REITs. Empirical tests are also conducted to uncover the returns characteristics of the M-REIT market. M-REIT returns are significantly correlated with domestic stock markets but only weakly correlated with changes in interest rate, with long-term proxies having a stronger impact than short-term proxies. The results from a correlation analysis are further confirmed by regression testing which shows that M-REIT returns are most significantly driven by domestic stock market returns while only mildly by changes in interest rates and not significantly driven by returns in regional REIT markets. These findings possibly imply that M-REITs (i) subscribe more to the characteristics of equity than those of bonds, (ii) are not 'pure' yield-play instruments, (iii) are often regarded as long-term investment, and (iv) may not be fully integrated with global and regional REIT markets.

Connectivity-based thalamus parcellation and surgical targeting of somatosensory subnuclei

2021 ◽  
pp. 1-8
Author(s):  
Ashley L. B. Raghu ◽  
Sean C. Martin ◽  
Tariq Parker ◽  
Tipu Z. Aziz ◽  
Alexander L. Green
Keyword(s):  
Electrode Array ◽  
Leg Pain ◽  
Patient Specific ◽  
Chronic Neuropathic Pain ◽  
Arm Pain ◽  
Face Pain ◽  
Pain Patients ◽  
And Diffusion ◽  
Term Benefit

OBJECTIVE The anatomy of the posterolateral thalamus varies substantially between individuals, presenting a challenge for surgical targeting. Patient-specific, connectivity-based parcellation of the thalamus may effectively approximate the ventrocaudal nucleus (Vc). This remains to be robustly validated or assessed as a method to guide surgical targeting. The authors assessed the validity of connectivity-based parcellation for targeting the Vc and its potential for improving clinical outcomes of pain surgery. METHODS A cohort of 19 patients with regional, chronic neuropathic pain underwent preoperative structural and diffusion MRI, then progressed to deep brain stimulation targeting the Vc based on traditional atlas coordinates. Surgical thalami were retrospectively segmented and then parcellated based on tractography estimates of thalamocortical connectivity. The location of each patient’s electrode array was analyzed with respect to their primary somatosensory cortex (S1) parcel and compared across patients with reference to the thalamic homunculus. RESULTS Ten patients achieved long-term pain relief. Sixty-one percent of an average array (interquartile range 42%–74%) was located in the S1 parcel. In patients who achieved long-term benefit from surgery, array location in the individually generated S1 parcels was medial for face pain, centromedial for arm pain, and centrolateral for leg pain. Patients who did not benefit from surgery did not follow this pattern. Standard stereotactic coordinates of electrode locations diverged from this pattern. CONCLUSIONS Connectivity-based parcellation of the thalamus appears to be a reliable method for segmenting the Vc. Identifying the Vc in this way, and targeting mediolaterally as appropriate for the region of pain, merits exploration in an effort to increase the yield of successful surgical procedures.

scholarly journals A kleptoplastidic dinoflagellate and the tipping point between transient and fully integrated plastid endosymbiosis

2019 ◽  
Vol 116 (36) ◽  
pp. 17934-17942 ◽  
Author(s):  
Elisabeth Hehenberger ◽  
Rebecca J. Gast ◽  
Patrick J. Keeling
Keyword(s):  
Posttranscriptional Regulation ◽  
Ross Sea ◽  
Environmental Parameters ◽  
Tipping Point ◽  
Fully Integrated ◽  
Regulation Mechanisms ◽  
The Antarctic ◽  
Integration Levels ◽  
Genetic Integration

Plastid endosymbiosis has been a major force in the evolution of eukaryotic cellular complexity, but how endosymbionts are integrated is still poorly understood at a mechanistic level. Dinoflagellates, an ecologically important protist lineage, represent a unique model to study this process because dinoflagellate plastids have repeatedly been reduced, lost, and replaced by new plastids, leading to a spectrum of ages and integration levels. Here we describe deep-transcriptomic analyses of the Antarctic Ross Sea dinoflagellate (RSD), which harbors long-term but temporary kleptoplasts stolen from haptophyte prey, and is closely related to dinoflagellates with fully integrated plastids derived from different haptophytes. In some members of this lineage, called the Kareniaceae, their tertiary haptophyte plastids have crossed a tipping point to stable integration, but RSD has not, and may therefore reveal the order of events leading up to endosymbiotic integration. We show that RSD has retained its ancestral secondary plastid and has partitioned functions between this plastid and the kleptoplast. It has also obtained genes for kleptoplast-targeted proteins via horizontal gene transfer (HGT) that are not derived from the kleptoplast lineage. Importantly, many of these HGTs are also found in the related species with fully integrated plastids, which provides direct evidence that genetic integration preceded organelle fixation. Finally, we find that expression of kleptoplast-targeted genes is unaffected by environmental parameters, unlike prey-encoded homologs, suggesting that kleptoplast-targeted HGTs have adapted to posttranscriptional regulation mechanisms of the host.

scholarly journals Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Dong-Wook Park ◽  
Amelia A. Schendel ◽  
Solomon Mikael ◽  
Sarah K. Brodnick ◽  
Thomas J. Richner ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Electrode Array ◽  
Electrode Arrays ◽  
Neural Imaging ◽  
Brain Surface ◽  
Array Technology ◽  
Micro Electrode Arrays ◽  
The Brain

Abstract Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.

Trends underlying early-stage drug discovery and development collaborations from October 2002 to September 2004

2005 ◽  
Vol 11 (4) ◽  
Author(s):  
Mark J Belsey ◽  
Alex K Pavlou
Keyword(s):  
Drug Discovery ◽  
Early Stage ◽  
Target Identification ◽  
New Wave ◽  
Fully Integrated ◽  
Drug Discovery And Development ◽  
The Past ◽  
Initial Stage ◽  
Increasing Demand

As part of Datamonitor's alliance and licensing strategic analysis, the authors have completed a two year survey of the trends underlying early-stage drug discovery and development collaborations between October 2002 and September 2004, which included 524 early-stage deals. Deal analysis shows that the leading pharma and biotech companies (fully integrated players) are the principal collaboration seekers, and that target and product innovation is driving the new wave of 21st century deals. These deals cover all phases of early-stage drug development, with lead product/target identification/validation accounting for the greatest proportion of collaborations. This represents a shift away from initial-stage collaborations, which are primarily focused on technologies such as genomics, as a result of the lack of tangible results that such technologies have delivered in the past. Following the continuously increasing demand for late-stage high-value products, the aim of the money and time invested in these early-stage collaborations is to reverse the pipeline productivity crisis currently affecting the industry's leaders over the mid to long term.

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