Real-Time Displacement and Cavitation Imaging of Non-Invasive Neuromodulation of the Peripheral Nervous System via Focused Ultrasound

2018 ◽  
Author(s):  
Stephen A. Lee ◽  
Hermes A.S. Kamimura ◽  
Mark T. Burgess ◽  
Antonios Pouliopoulos ◽  
Elisa E. Konofagou
Keyword(s):  
Nervous System ◽  
Real Time ◽  
Peripheral Nervous System ◽  
Focused Ultrasound ◽  
Non Invasive

Confocal retinal microscopy - the new non-invasive method for diagnostics of the early manifestations of the lesions in the peripheral nervous system associated with diabetes mellitus

2015 ◽  
Vol 61 (2) ◽  
pp. 32-38 ◽  
Author(s):  
E V Artemova ◽  
G R Galstyan ◽  
D S Atarshchikov ◽  
A A Malchugina ◽  
I I Dedov
Keyword(s):  
Diabetes Mellitus ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Infectious Complications ◽  
Preclinical Stage ◽  
Non Invasive ◽  
End Point ◽  
Puncture Biopsy ◽  
Invasive Method ◽  
Reliable Methods

There are presently no reliable methods for diagnostics of the early manifestations of the lesions in the peripheral nervous system. Only puncture biopsy of the skin and the nerves can be used at the preclinical stage. However, the application of these invasive methods is fraught with the risk of infectious complications. Confocal retinal microscopy is the new non-invasive morphometric technique that permits to reveal the early signs of the lesions in the peripheral nervous system and to study dynamics of the associated changes that can be used as a valid surrogate end point for the evaluation of the effectiveness of pharmacotherapy.

Peripheral neuropathic pain

2020 ◽  
Vol 47 (3) ◽  
pp. 265-283
Author(s):  
Douglas Murphy ◽  
Denise Lester ◽  
F. Clay Smither ◽  
Ellie Balakhanlou
Keyword(s):  
Nervous System ◽  
Neuropathic Pain ◽  
Peripheral Nervous System ◽  
Nerve Blocks ◽  
Peripheral Neuropathic Pain ◽  
Non Invasive ◽  
Wide Range ◽  
The Cost ◽  
And Control

Neuropathic pain (NP) can have either central nervous system causes or ones from the peripheral nervous system. This article will focus on the epidemiology, classifications, pathology, non-invasive treatments and invasive treatments as a general review of NP involving the peripheral nervous system. NP has characteristic symptomatology such as burning and electrical sensations. It occurs in up to 10% of the general population. Its frequency can be attributed to its occurrence in neck and back pain, diabetes and patients receiving chemotherapy. There are a wide range of pharmacologic options to control this type of pain and when such measures fail, numerous interventional methods can be employed such as nerve blocks and implanted stimulators. NP has a cost to the patient and society in terms of emotional consequences, quality of life, lost wages and the cost of assistance from the medical system and thus deserves serious consideration for prevention, treatment and control.

scholarly journals Image-guided focused ultrasound modulates electrically evoked motor neuronal activity in the mouse peripheral nervous system in vivo

2020 ◽  
Vol 17 (2) ◽  
pp. 026026 ◽  
Author(s):  
Min Gon Kim ◽  
Hermes A S Kamimura ◽  
Stephen A Lee ◽  
Christian Aurup ◽  
Nancy Kwon ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Neuronal Activity ◽  
Focused Ultrasound ◽  
Image Guided

scholarly journals Peripheral Nerve Focused Ultrasound Lesioning—Visualization and Assessment Using Diffusion Weighted Imaging

2021 ◽  
Vol 12 ◽  
Author(s):  
Matthew R. Walker ◽  
Jidan Zhong ◽  
Adam C. Waspe ◽  
Karolina Piorkowska ◽  
Lananh N. Nguyen ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Diffusion Weighted Imaging ◽  
Quantitative Assessment ◽  
Focused Ultrasound ◽  
Non Invasive ◽  
Diffusion Weighted ◽  
Sciatic Nerves ◽  
And Diffusion

Objectives: Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive targeted tissue ablation technique that can be applied to the nervous system. Diffusion weighted imaging (DWI) can visualize and evaluate nervous system microstructure. Tractography algorithms can reconstruct fiber bundles which can be used for treatment navigation and diffusion tensor imaging (DTI) metrics permit the quantitative assessment of nerve microstructure in vivo. There is a need for imaging tools to aid in the visualization and quantitative assessment of treatment-related nerve changes in MRgFUS. We present a method of peripheral nerve tract reconstruction and use DTI metrics to evaluate the MRgFUS treatment effect.Materials and Methods: MRgFUS was applied bilaterally to the sciatic nerves in 6 piglets (12 nerves total). T1-weighted and diffusion images were acquired before and after treatment. Tensor-based and constrained spherical deconvolution (CSD) tractography algorithms were used to reconstruct the nerves. DTI metrics of fractional anisotropy (FA), and mean (MD), axial (AD), and radial diffusivities (RD) were measured to assess acute (<1–2 h) treatment effects. Temperature was measured in vivo via MR thermometry. Histological data was collected for lesion assessment.Results: The sciatic nerves were successfully reconstructed in all subjects. Tract disruption was observed after treatment using both CSD and tensor models. DTI metrics in the targeted nerve segments showed significantly decreased FA and increased MD, AD, and RD. Transducer output power was positively correlated with lesion volume and temperature and negatively correlated with MD, AD, and RD. No correlations were observed between FA and other measured parameters.Conclusions: DWI and tractography are effective tools for visualizing peripheral nerve segments for targeting in non-invasive surgical methods and for assessing the microstructural changes that occur following MRgFUS treatment.

scholarly journals AQUA: an Advanced QUery Architecture for the SPARC Portal

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 930
Author(s):  
Niloofar Shahidi ◽  
Xuanzhi Lin ◽  
Yuda Munarko ◽  
Laila Rasmy ◽  
Tram Ngo
Keyword(s):  
Nervous System ◽  
Real Time ◽  
Peripheral Nervous System ◽  
Search Engine ◽  
Neural Information ◽  
Search Tool ◽  
Dynamic Storage

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program integrates biological and neural information to create anatomical and functional maps of the peripheral nervous system. The SPARC Portal hosts a dynamic storage for the datasets, models, and resources to help the researchers find and produce data. Currently, the SPARC Portal provides a primary search tool, which lacks some features to improve the search experience. To purposefully retrieve the required information from the stored datasets and resources, we have developed an Advanced QUery Architecture (AQUA) for the SPARC Portal. Near-real-time auto-completion of the queries, close-matches suggestions, and multiple filters to narrow or sort the results are the major features of AQUA with the goal to enhance the usability of the SPARC search engine. AQUA is available from: https://github.com/SPARC-FAIR-Codeathon/aqua

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