Case of anti‐nuclear matrix protein 2 antibody‐positive juvenile dermatomyositis preceded by linear cutaneous lupus erythematosus on the face

A 60-year-old female was diagnosed with progressive systemic sclerosis and interstitial lung disease of two months’ duration. The patient was treated for Raynaud phenomenon with aspirin, nifedipine, colchicine, and naproxen. Two weeks after treatment, she developed widespread erythematous patches with blistering eruptions on the face, torso, and extremities, and also had erosion on the oral mucosa. Skin biopsy for histopathology and direct immunofluorescent studies were suggestive of lupus erythematosus. To the best of our knowledge, this is the first case of toxic epidermal necrolysis-like acute cutaneous lupus erythematosus in a patient with progressive systemic sclerosis.

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Isoniazid - induced chronic cutaneous Lupus erythematosus

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v13i1.14306 ◽

2016 ◽

Vol 13 (1) ◽

pp. 52-56

Author(s):

A Chiriac ◽

P Brzezinski ◽

A E Chiriac ◽

L Foia ◽

D Mihaila ◽

...

Keyword(s):

Lupus Erythematosus ◽

Histopathological Examination ◽

Cutaneous Lupus Erythematosus ◽

Clinical Aspects ◽

Direct Immunofluorescence ◽

Drug Induced ◽

Systemic Involvement ◽

Antituberculosis Therapy ◽

The Face ◽

Cutaneous Lupus

A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, along with direct immunofluorescence examination (DIF), the absence of systemic involvement and the routine laboratory parameters, which registered all within normal range. Hydroxychloroquine therapy associated to photo protection and emollients determined the clear up of the facial eruption within six months. Transient residual hyperpigmentation could be noticed 2 months after discontinuation of the treatment. This case illustrates a rare form of drug-induced chronic cutaneous lupus erythematosus developed 2 months after withdrawal of antituberculosis therapy, with excellent results with hydroxychloroquine.NJDVL Vol. 13, No. 1, 2015 Page: 52-56

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A different kind of skin presentation in Systemic Lupus Erythematosus (SLE): A case report

Asian Journal of Medicine and Biomedicine ◽

10.37231/ajmb.2020.4.1.329 ◽

2020 ◽

Vol 4 (1) ◽

pp. 42-46

Author(s):

Huzairi Sani ◽

Nada Syazana ◽

Malek Faris Riza Feisal

Keyword(s):

Systemic Lupus Erythematosus ◽

Case Report ◽

Lupus Erythematosus ◽

Erythema Nodosum ◽

Cutaneous Lupus Erythematosus ◽

Systemic Lupus ◽

Cutaneous Manifestations ◽

Subcutaneous Nodules ◽

The Face ◽

Cutaneous Lupus

Erythema nodosum is a septal panniculitis which is a variant of chronic cutaneous lupus erythematosus (CCLE). It is further classified in the group of Lupus Erythematous Panniculitis (LEP).[1] The most frequent cutaneous manifestations include indurated plaques, subcutaneous nodules and sometimes ulcerations. The lesions occur predominantly on the face, upper arms, upper trunk, breasts, buttocks and thighs.[2] They occur most frequently in adult females and do not typically manifest cutaneously in Systemic Lupus Erythematosus (SLE).[3] In this case report, we discuss a young gentleman who presented with erythema nodosum as a cutaneous feature of SLE. Keywords: Systemic lupus erythematosus, erythema nodosum, panniculitis, cutaneous lupus

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