l-arginine andl-NMMA for assessing cerebral endothelial dysfunction in ischaemic cerebrovascular disease: A systematic review

2016 ◽  
Vol 44 (1) ◽  
pp. 13-20 ◽  
Author(s):  
William K Karlsson ◽  
Caspar G Sørensen ◽  
Christina Kruuse
Keyword(s):  
Systematic Review ◽  
Endothelial Dysfunction ◽  
Cerebrovascular Disease ◽  
Ischaemic Cerebrovascular Disease

Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily

2006 ◽  
Vol 96 (08) ◽  
pp. 154-159 ◽  
Author(s):  
Rosa-Maria Guéant-Rodriguez ◽  
Guido Anello ◽  
Rosario Spada ◽  
Antonino Romano ◽  
Adrian Fajardo ◽  
...  
Keyword(s):  
Cerebrovascular Disease ◽  
Vitamin B12 ◽  
Methylenetetrahydrofolate Reductase ◽  
Methionine Synthase ◽  
Italian Population ◽  
Significant Independent Predictor ◽  
Methionine Synthase Reductase ◽  
Ischaemic Cerebrovascular Disease ◽  
Folate And Vitamin B12 ◽  
Neutral Effect

SummaryAssociation between methylenetetrahydrofolate reductase polymorphism (MTHFR 677 C>T), a determinant of homocysteine plasma level (t-Hcys), with ischaemc cerebrovascular disease (iCVD) seems to be neutral in North Europe and North America. The association of 2756 A>G of methionine synthase (MTR), 66 A>G of methionine synthase reductase (MTRR) and 776 C>G of transcobalamin (TCN2) needs to be evaluated further. It was the objective of this study to evaluate the association of these polymorphisms, t-Hcys, vitamin B12 and folate levels with iCVD, in an Italian population from Sicily. We investigated the association of these polymorphisms, t-Hcys, vitamin B12 and folate with iCVD in 252 subjects, including 131 cases and 121 sexand agematched healthy controls. t-Hcys was higher in the iCVD group than in controls [15.3 (11.5–17.9) vs. 11.6 (9.4–14.5) µM; P=0. 0007] and also in subjects withTCN2 776CG genotype, compared to homozygous genotypes [13.5 (9.9± 16.9) vs. 11.7 (9.6 ± 14.4) µM; P=0. 0327]. The folate level in cases and controls was consistent with an adequate dietary intake [12.7 (9.0–15.3) vs. 12.5 (9.6–16.9) nM; P=0. 7203]. In multivariate analysis, t-Hcys was a significant independent predictor of iCVD with an odds ratio of 1.14 (95% C.I. : 1.06–1.24; P=0. 0006). No association was found between MTHFR, MTR, MTRR and TCN2 polymorphisms and iCVD risk. We have found an influence of t-Hcys and a neutral effect of MTHFR, MTR, MTRR and TCN2 on iCVD risk in Sicily. The neutral influence of these polymorphisms may be explained by adequate status in folate and vitamin B12. Other factors underlying the increased t-Hcys need further investigations.

Abstract TP525: Pharmacological Smoking Cessation Therapies for Patients With Cerebrovascular Disease: A Systematic Review

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Neal S Parikh ◽  
Setareh Salehi Omran ◽  
Mitchell S Elkind ◽  
Joshua Willey
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Cerebrovascular Disease

scholarly journals Diagnostic accuracy of flat-panel computed tomography in assessing cerebral perfusion in comparison with perfusion computed tomography and perfusion magnetic resonance: a systematic review

2019 ◽  
Vol 61 (12) ◽  
pp. 1457-1468 ◽  
Author(s):  
Ernst L. Stille ◽  
Ilaria Viozzi ◽  
Mark ter Laan ◽  
Frederick J.A. Meijer ◽  
Jurgen J. Futterer ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systematic Review ◽  
Magnetic Resonance ◽  
Diagnostic Accuracy ◽  
Cerebrovascular Disease ◽  
Blood Volume ◽  
Perfusion Imaging ◽  
Cerebral Perfusion ◽  
Flat Panel ◽  
Perfusion Computed Tomography

Abstract Purpose Flat-panel computed tomography (FP-CT) is increasingly available in angiographic rooms and hybrid OR’s. Considering its easy access, cerebral imaging using FP-CT is an appealing modality for intra-procedural applications. The purpose of this systematic review is to assess the diagnostic accuracy of FP-CT compared with perfusion computed tomography (CTP) and perfusion magnetic resonance (MRP) in cerebral perfusion imaging. Methods We performed a systematic literature search in the Cochrane Library, MEDLINE, Embase, and Web of Science up to June 2019 for studies directly comparing FP-CT with either CTP or MRP in vivo. Methodological quality was assessed using the QUADAS-2 tool. Data on diagnostic accuracy was extracted and pooled if possible. Results We found 11 studies comparing FP-CT with CTP and 5 studies comparing FP-CT with MRP. Most articles were pilot or feasibility studies, focusing on scanning and contrast protocols. All patients studied showed signs of cerebrovascular disease. Half of the studies were animal trials. Quality assessment showed unclear to high risks of bias and low concerns regarding applicability. Five studies reported on diagnostic accuracy; FP-CT shows good sensitivity (range 0.84–1.00) and moderate specificity (range 0.63–0.88) in detecting cerebral blood volume (CBV) lesions. Conclusions Even though FP-CT provides similar CBV values and reconstructed blood volume maps as CTP in cerebrovascular disease, additional studies are required in order to reliably compare its diagnostic accuracy with cerebral perfusion imaging.

Circulatory Reflexes in Cerebral Ischaemia Involving Different Vascular Territories

1970 ◽  
Vol 38 (4) ◽  
pp. 491-502 ◽  
Author(s):  
M. Gross
Keyword(s):  
Statistical Analysis ◽  
Arterial Pressure ◽  
Cerebrovascular Disease ◽  
Internal Carotid ◽  
Transient Ischaemic Attacks ◽  
Vasoconstrictor Response ◽  
Ischaemic Cerebrovascular Disease ◽  
Significant Difference ◽  
Valsalva's Manoeuvre ◽  
Circulatory Reflexes

1. Circulatory reflex function was assessed in a series of subjects with chronic ischaemic cerebrovascular disease and compared with a group of subjects with no known cerebrovascular disease by intra-arterial pressure responses to Valsalva's manoeuvre. 2. Circulatory reflexes were impaired in the patients with cerebrovascular disease as compared with controls, but statistical analysis indicated that age was a more important factor than chronic cerebrovascular disease in producing the deterioration. 3. No significant difference was found in the circulatory reflex function of subjects with ischaemia in the internal carotid territory when compared with those having ischaemia in the vertebrobasilar territory. 4. Combined ischaemia in both carotid and vertebrobasilar territories significantly impaired the cardioaccelerator but not the vasoconstrictor response to Valsalva's manoeuvre. 5. No significant difference was found in circulatory reflex function in subjects who had suffered cerebral infarction as opposed to transient ischaemic attacks.

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