Edible Filamentous Fungi from the SpeciesMonascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics

In 1990, Charles Mackay and colleagues combined classical physiology with modern molecular biology to provide the first concrete evidence that naive and memory T cells follow distinct migratory routes out of the bloodstream— a discovery that helped invigorate the field of lymphocyte homing.

Download Full-text

Anniversary of the Theory of Academician E.N. Pavlovsky about the Natural Focality of Diseases (1939 - 2014)

Epidemiology and Vaccinal Prevention ◽

10.31631/2073-3046-2015-14-1-9-16 ◽

2015 ◽

Vol 14 (1) ◽

pp. 9-16 ◽

Cited By ~ 1

Author(s):

E. I. Korenberg

Keyword(s):

Molecular Biology ◽

75Th Anniversary ◽

Modern Molecular Biology ◽

Natural Foci ◽

Ecological Methods ◽

Traditional Population

In connection with the 75th anniversary of the theory of academician E.N. Pavlovsky about the natural focality of diseases presents the General results of the development of its fundamental theoretical positions. Planned most promising areas for further research, which can immeasurably increase when the combination of modern molecular biology and traditional population-ecological methods for the study of natural foci.

Download Full-text

RNA-Targeting CRISPR–Cas Systems and Their Applications

International Journal of Molecular Sciences ◽

10.3390/ijms21031122 ◽

2020 ◽

Vol 21 (3) ◽

pp. 1122 ◽

Cited By ~ 7

Author(s):

Michal Burmistrz ◽

Kamil Krakowski ◽

Agata Krawczyk-Balska

Keyword(s):

Molecular Biology ◽

Current Knowledge ◽

Type Ii ◽

Rna Molecules ◽

Dna Targeting ◽

Modern Molecular Biology ◽

Rna Targeting ◽

New Research ◽

Target Rna ◽

Research Tools

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)–CRISPR-associated (Cas) systems have revolutionized modern molecular biology. Numerous types of these systems have been discovered to date. Many CRISPR–Cas systems have been used as a backbone for the development of potent research tools, with Cas9 being the most widespread. While most of the utilized systems are DNA-targeting, recently more and more attention is being gained by those that target RNA. Their ability to specifically recognize a given RNA sequence in an easily programmable way makes them ideal candidates for developing new research tools. In this review we summarize current knowledge on CRISPR–Cas systems which have been shown to target RNA molecules, that is type III (Csm/Cmr), type VI (Cas13), and type II (Cas9). We also present a list of available technologies based on these systems.

Download Full-text