Overdose and take‐home naloxone in emergency settings: A pilot study examining feasibility of delivering brief interventions addressing overdose prevention with ‘take‐home naloxone’ in emergency departments

2022 ◽  
Author(s):  
Eleanor Black ◽  
Lauren A Monds ◽  
Betty Chan ◽  
Jonathan Brett ◽  
Jennie E Hutton ◽  
...  
Keyword(s):  
Pilot Study ◽  
Emergency Departments ◽  
Brief Interventions ◽  
Overdose Prevention

scholarly journals A pilot study of alcohol screening and brief interventions in community pharmacies

2012 ◽  
Vol 7 (S1) ◽  
Author(s):  
Niamh Fitzgerald ◽  
Derek Stewart ◽  
Mariesha Jaffray ◽  
Jackie Inch ◽  
Eilidh Duncan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Alcohol Screening ◽  
Brief Interventions ◽  
Community Pharmacies

scholarly journals Provision of naloxone to injection drug users as an overdose prevention strategy: Early evidence from a pilot study in New York City

2006 ◽  
Vol 31 (5) ◽  
pp. 907-912 ◽  
Author(s):  
Sandro Galea ◽  
Nancy Worthington ◽  
Tinka Markham Piper ◽  
Vijay V. Nandi ◽  
Matt Curtis ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
Pilot Study ◽  
York City ◽  
Injection Drug Users ◽  
Drug Users ◽  
Prevention Strategy ◽  
Injection Drug ◽  
Overdose Prevention ◽  
Early Evidence

scholarly journals A realist review of brief interventions for alcohol misuse delivered in emergency departments

2021 ◽  
Author(s):  
Caitlin J Davey ◽  
Meredith SH Landy ◽  
Amanda Pecora ◽  
David Quintero ◽  
Kelly E McShane
Keyword(s):  
Alcohol Use ◽  
Emergency Departments ◽  
Clinical Decision Making ◽  
Alcohol Misuse ◽  
Realist Review ◽  
Clinical Decision ◽  
Brief Interventions ◽  
Future Research ◽  
Healthcare Settings ◽  
Favorable Conditions

Background: Brief interventions (BIs) involve screening for alcohol misuse and providing feedback to patients about their use, with the aim of reducing alcohol consumption and related consequences. BIs have been implemented in various healthcare settings, including emergency departments (ED), where they have been found to contribute mixed results in their ability to address alcohol misuse among adults. Mechanisms through which BIs work and contextual factors impacting BI effectiveness are not clear. The purpose of this review was to understand how, for whom, and under what circumstances BIs work for adults misusing alcohol and who have been admitted to an ED. A realist review was chosen to answer these questions as realist reviews create context-mechanism-outcome configurations, leading to the development of comprehensive and detailed theories; in this case explaining how and for whom BIs work. Methods: Databases including PsycINFO, Healthstar, CINAHL, Medline, and Nursing and Allied Health were searched for articles published until December 2013. The search strategy focused on studies examining BIs that targeted alcohol misuse among adults admitted into the ED. The search identified 145 relevant abstracts, of which 36 were included in the review. The literature was synthesized qualitatively (immersion/crystallization). Results: Four mechanisms were found within reviewed studies, including engagement in/retention of BI materials, resolving ambivalence, increased awareness/insight into consequences of drinking, and increased self-efficacy/empowerment to use skills for change. The following contexts were found to impact mechanisms: emotional state, injury attributed to alcohol use, severity of alcohol use, and baseline stage of change. Conclusions: This realist review provides advances in theories regarding which mechanisms to target during a BI and which contexts create the most favorable conditions for these mechanisms to occur, ultimately leading to optimal BI outcomes. These results can inform future clinical decision-making when delivering BIs in ED settings. Future research should conduct quantitative examination to confirm these findings. Systematic review registration: PROSPERO CRD42013006549

scholarly journals How Do Advanced Molecular Tests Compare to Routine Clinical Laboratory Evaluation of CSF in Meningoencephalitis? A Study in 10 Urban Emergency Departments Across the USA

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S8-S9 ◽  
Author(s):  
Toby L Merlin ◽  
Scott Chancey ◽  
Yueli Zheng ◽  
Brad Bowzard ◽  
Leah Fischer ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Pilot Study ◽  
Emergency Departments ◽  
Clinical Laboratory ◽  
Targeted Sequencing ◽  
Laboratory Evaluation ◽  
Next Generation ◽  
Molecular Tests ◽  
Causative Agents ◽  
Generation Sequencing

Abstract Background The EMERGEncy ID Net Study Group is investigating whether advanced molecular tests (AMT) increase the detection of causative agents in the CSF of patients presenting with meningoencephalitis (ME). We report findings from a pilot study using AMT on 18 CSF samples from 10 US Urban Emergency Departments. The purpose of the pilot was to compare the performance of these four AMT to established clinical laboratory methods. Methods We investigated four AMT: (1) BioFire FilmArray ME Panel targeting 14 causative agents; (2) an in-house target-directed next generation sequencing assay targeting 25 agents; (3) a microarray capable of detecting >2,500 agents; and (4) deep metagenomic next generation sequencing. For targeted sequencing, loci from 12 DNA-based and 13 RNA-based pathogens were amplified from the extracts by multiplex PCR. All sequencing was performed on an Illumina MiSeq using 500 cycle v2 Reagent Kits. Reads from the targeted sequencing were aligned to the 25 specific reference target sequences using Bowtie2 while metagenomics reads were processed with the taxonomic sequence classifying software Kraken. For microarray analysis, Lawrence Livermore Microbial Detection Array v2 arrays were hybridized with Cy3-labeled DNA or cDNA. Scanned images of arrays were analyzed by CLiMax 3.1. Results Eight CSF samples had results positive for well-established causes of ME from prior testing (Table). The pilot study demonstrated none of the four AMT detected all causative agents in the eight CSF samples known to have well-established causes of ME. BioFire and targeted sequencing performed best, both detecting 6/8, metagenomics deep sequencing detected 3/8, and microarray detected 1/8. Conclusion Despite the sophistication of AMT, they cannot detect pathogens they do not target, that are present in small numbers, or that have been eliminated from the CSF by the immune response. Despite the theoretical potential for microarray and metagenomic sequencing to detect thousands of different agents, the agents probably must be present at high levels for detection. Disclosures All authors: No reported disclosures.

scholarly journals Brief interventions to de-escalate disturbances in emergency departments

2018 ◽  
Vol 27 (6) ◽  
pp. 322-327
Author(s):  
Karen-leigh Edward ◽  
Jo-Ann Giandinoto ◽  
Tracey J Weiland ◽  
Jennie Hutton ◽  
Sarah Reel
Keyword(s):  
Emergency Departments ◽  
Brief Interventions
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