Comparative proton versus photon treatment planning for the Medicare Medical Treatment Overseas Program: The Royal Adelaide Hospital experience

Aim: This study evaluated clinical outcomes of combined chemotherapy and Endoscopic Ultrasound (EUS) guided intra-tumoral radioactive phosphorus-32 (32P OncoSil) implantation in locally advanced pancreatic adenocarcinoma (LAPC). Methods: Consecutive patients with a new histological diagnosis of LAPC were recruited over 20 months. Baseline CT and 18FDG PET-CT were performed and repeated after 12 weeks to assess response to treatment. Following 2 cycles of conventional chemotherapy, patients underwent EUS-guided 32P OncoSil implantation followed by a further six cycles of chemotherapy. Results: Twelve patients with LAPC (8M:4F; median age 69 years, IQR 61.5-73.3) completed the treatment. Technical success was 100% and no procedural complications were reported. At 12 weeks, there was a median reduction of 8.2cm3 (95% CI 4.95-10.85; p=0.003) in tumour volume, with minimal or no 18FDG uptake in 9 (75%) patients. Tumour downstaging was achieved in 6 (50%) patients, leading to successful resection in 5 (42%) patients, of which 4 patients (80%) had clear (R0) resection margins. Conclusions: EUS guided 32P OncoSil implantation is feasible and well tolerated and was associated with a 42% rate of surgical resection in our cohort. However, further evaluation in a larger randomized multicenter trial is warranted. (32P funded by OncoSil Medical Ltd, equipment and staff funded by the Royal Adelaide Hospital, ClinicalTrials.gov number, NCT03003078).

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THE CAUSES OF DEATH IN DIABETES MELLITUS: A STUDY OF DIABETIC MORTALITY IN THE ROYAL ADELAIDE HOSPITAL FROM 1956 TO 1960

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1963.tb23450.x ◽

1963 ◽

Vol 1 (24) ◽

pp. 890-894 ◽

Cited By ~ 6

Author(s):

Anthony Seymour and David Phear

Keyword(s):

Diabetes Mellitus ◽

Causes Of Death ◽

Adelaide Hospital ◽

Royal Adelaide Hospital

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Anaemia in elective orthopaedic surgery - Royal Adelaide Hospital, Australia

Internal Medicine Journal ◽

10.1111/imj.12945 ◽

2016 ◽

Vol 46 (1) ◽

pp. 96-101 ◽

Cited By ~ 5

Author(s):

B. Kearney ◽

J. To ◽

K. Southam ◽

D. Howie ◽

B. To

Keyword(s):

Orthopaedic Surgery ◽

Adelaide Hospital ◽

Royal Adelaide Hospital

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INCREASING NUMBERS OF ADMISSIONS TO THE ADULT BURNS SERVICE AT THE ROYAL ADELAIDE HOSPITAL 2001?2004

ANZ Journal of Surgery ◽

10.1111/j.1445-2197.2007.04060.x ◽

2007 ◽

Vol 77 (5) ◽

pp. 358-363 ◽

Cited By ~ 14

Author(s):

John E. Greenwood ◽

Richard Tee ◽

Wendy L. Jackson

Keyword(s):

Adelaide Hospital ◽

Royal Adelaide Hospital

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Reliability of Blood Sugar Reagent Strips

Anaesthesia and Intensive Care ◽

10.1177/0310057x7400200311 ◽

1974 ◽

Vol 2 (3) ◽

pp. 256-259 ◽

Cited By ~ 1

Author(s):

D. J. McCleave

Keyword(s):

Blood Sugar ◽

Severe Hypoglycaemia ◽

Adelaide Hospital ◽

Royal Adelaide Hospital ◽

Lower Blood ◽

Reagent Strips ◽

The Stability

Two cases of severe hypoglycaemia following the use of insulin after blood sugar reagent strips indicated an erroneously high value, precipitated an investigation into the reliability of all reagent strips currently being used at the Royal Adelaide Hospital. It was found that when compared to Autoanalyzer values, such a method of blood sugar estimation is unacceptable for clinical useage. Reagent Strips taken from recently opened containers gave reasonably accurate results for lower blood sugar values. It is concluded that such inaccurate results are related to the stability of the reagent strips.

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