scholarly journals Reliability of Blood Sugar Reagent Strips

1974 ◽  
Vol 2 (3) ◽  
pp. 256-259 ◽  
Author(s):  
D. J. McCleave
Keyword(s):  
Blood Sugar ◽  
Severe Hypoglycaemia ◽  
Adelaide Hospital ◽  
Royal Adelaide Hospital ◽  
Lower Blood ◽  
Reagent Strips ◽  
The Stability

Two cases of severe hypoglycaemia following the use of insulin after blood sugar reagent strips indicated an erroneously high value, precipitated an investigation into the reliability of all reagent strips currently being used at the Royal Adelaide Hospital. It was found that when compared to Autoanalyzer values, such a method of blood sugar estimation is unacceptable for clinical useage. Reagent Strips taken from recently opened containers gave reasonably accurate results for lower blood sugar values. It is concluded that such inaccurate results are related to the stability of the reagent strips.

THERAPIE EINES METASTASIERENDEN INSELZELLTUMORS MIT STREPTOZOTOCIN

1971 ◽  
Vol 67 (2) ◽  
pp. 405-416 ◽  
Author(s):  
E. Nieschlag ◽  
H. Wombacher ◽  
F. J. Kroeger ◽  
L.V. Habighorst
Keyword(s):  
Liver Metastases ◽  
Blood Sugar ◽  
Mechanism Of Action ◽  
Islet Cell ◽  
Plasma Insulin ◽  
Severe Hypoglycaemia ◽  
Islet Cells ◽  
Intravenous Injections ◽  
High Affinity ◽  
Methyl Nitrosourea

A patient with a metastazing functional islet cell tumour suffering from severe hypoglycaemia was treated with streptozotocin. Four intravenous injections of 1.5 g streptozotocin each were administered in 4 to 6 days intervals. After the 4th injection there were no further episodes of hypoglycaemia, parenteral glucose administration could be stopped and blood sugar and plasma insulin, showing concentrations of up to 405 μU/ml before treatment, reached normal levels. The tumours in the pancreas disappeared and the liver metastases decreased in size and number as judged by arteriography. A hypothesis for the mechanism of action of streptozotocin is proposed. The glucose moiety is considered to facilitate a high affinity to the islet cells whereas the N-methyl-nitrosourea residue serves the active antitumour part of the molecule.

Combined chemotherapy and EUS-guided intra-tumoral 32-P implantation for locally advanced pancreatic ductal adenocarcinoma: a pilot study

Endoscopy ◽  
2021 ◽  
Author(s):  
Jeevinesh Naidu ◽  
Dylan Bartholomeusz ◽  
Joshua Zobel ◽  
Romina Safaeian ◽  
William Hsieh ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Adelaide Hospital ◽  
Response To Treatment ◽  
Ductal Adenocarcinoma ◽  
Resection Margins ◽  
R0 Resection ◽  
Royal Adelaide Hospital ◽  
Combined Chemotherapy ◽  
Radioactive Phosphorus ◽  
18Fdg Pet

Aim: This study evaluated clinical outcomes of combined chemotherapy and Endoscopic Ultrasound (EUS) guided intra-tumoral radioactive phosphorus-32 (32P OncoSil) implantation in locally advanced pancreatic adenocarcinoma (LAPC). Methods: Consecutive patients with a new histological diagnosis of LAPC were recruited over 20 months. Baseline CT and 18FDG PET-CT were performed and repeated after 12 weeks to assess response to treatment. Following 2 cycles of conventional chemotherapy, patients underwent EUS-guided 32P OncoSil implantation followed by a further six cycles of chemotherapy. Results: Twelve patients with LAPC (8M:4F; median age 69 years, IQR 61.5-73.3) completed the treatment. Technical success was 100% and no procedural complications were reported. At 12 weeks, there was a median reduction of 8.2cm3 (95% CI 4.95-10.85; p=0.003) in tumour volume, with minimal or no 18FDG uptake in 9 (75%) patients. Tumour downstaging was achieved in 6 (50%) patients, leading to successful resection in 5 (42%) patients, of which 4 patients (80%) had clear (R0) resection margins. Conclusions: EUS guided 32P OncoSil implantation is feasible and well tolerated and was associated with a 42% rate of surgical resection in our cohort. However, further evaluation in a larger randomized multicenter trial is warranted. (32P funded by OncoSil Medical Ltd, equipment and staff funded by the Royal Adelaide Hospital, ClinicalTrials.gov number, NCT03003078).

Anaemia in elective orthopaedic surgery - Royal Adelaide Hospital, Australia

2016 ◽  
Vol 46 (1) ◽  
pp. 96-101 ◽  
Author(s):  
B. Kearney ◽  
J. To ◽  
K. Southam ◽  
D. Howie ◽  
B. To
Keyword(s):  
Orthopaedic Surgery ◽  
Adelaide Hospital ◽  
Royal Adelaide Hospital

INCREASING NUMBERS OF ADMISSIONS TO THE ADULT BURNS SERVICE AT THE ROYAL ADELAIDE HOSPITAL 2001?2004

2007 ◽  
Vol 77 (5) ◽  
pp. 358-363 ◽  
Author(s):  
John E. Greenwood ◽  
Richard Tee ◽  
Wendy L. Jackson
Keyword(s):  
Adelaide Hospital ◽  
Royal Adelaide Hospital

Some Effects of Prolonged Undernutrition on Carbohydrate Metabolism in Rats

1956 ◽  
Vol 187 (3) ◽  
pp. 432-436 ◽  
Author(s):  
N. S. Halmi ◽  
B. N. Spirtos
Keyword(s):  
Insulin Sensitivity ◽  
Blood Sugar ◽  
Initial Level ◽  
Liver Glycogen ◽  
Hepatic Glycogen ◽  
Glycogen Concentration ◽  
Insulin Tolerance ◽  
Lower Blood ◽  
Ad Libitum ◽  
Sugar Levels

A) Rats fed 10 gm of ground Rockland diet/day for 4–6 weeks and then fasted for 24 hours showed an enhanced insulin sensitivity as compared with ad libitum-fed rats that were fasted for the same length of time. The fasting blood sugar and liver glycogen concentrations were significantly higher in underfed animals. B) Underfed rats were fasted 24 hours, then fed 5 gm/ 100 gm body weight and tested 8 hours later. These rats exhibited a) no greater insulin sensitivity, b) lower blood sugar levels and c) a smaller rise in liver glycogen concentration than similarly treated ad libitum-fed animals. Intestinal absorption of glucose was not diminished in the undernourished rats. C) Cortisone treatment (0.5 mg/100 gm body wt/day for 5 days) abolished the insulin sensitivity of underfed rats without altering the hepatic glycogen concentration. Somatotrophin (0.5 mg Armour standard equivalent/100 gm body wt/day for 5 days) did not improve their insulin tolerance. After functional evisceration, the blood sugar fall (if expressed as percentage of the initial level) was significantly slower in underfed than in ad libitum-fed rats. However, the decline of the blood sugar level appeared to be more markedly enhanced by insulin in the underfed animals.

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