scholarly journals Nicotine self-administration remodels perineuronal nets in ventral tegmental area and orbitofrontal cortex in adult male rats

2016 ◽  
Vol 22 (6) ◽  
pp. 1743-1755 ◽  
Author(s):  
Dolores B. Vazquez-Sanroman ◽  
Reyna D. Monje ◽  
Michael T. Bardo
Keyword(s):  
Ventral Tegmental Area ◽  
Adult Male ◽  
Orbitofrontal Cortex ◽  
Male Rats ◽  
Perineuronal Nets ◽  
Self Administration ◽  
Ventral Tegmental

scholarly journals Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area

2021 ◽  
Author(s):  
Rianne R. Campbell ◽  
Siwei Chen ◽  
Joy H. Beardwood ◽  
Alberto J. López ◽  
Lilyana V. Pham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Home Cage ◽  
Expression Patterns ◽  
Energy Regulation ◽  
Biological Processes ◽  
Cocaine Exposure ◽  
Self Administration ◽  
Drug Reinforcement ◽  
Ventral Tegmental

AbstractDuring the initial stages of drug use, cocaine-induced neuroadaptations within the ventral tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement processes. These neuroadaptations occur, in part, from alterations to the transcriptome. Although cocaine-induced transcriptional mechanisms within the VTA have been examined, various regimens and paradigms have been employed to examine candidate target genes. In order to identify key genes and biological processes regulating cocaine-induced processes, we employed genome-wide RNA-sequencing to analyze transcriptional profiles within the VTA from male mice that underwent one of four commonly used paradigms: acute home cage injections of cocaine, chronic home cage injections of cocaine, cocaine-conditioning, or intravenous-self administration of cocaine. We found that cocaine alters distinct sets of VTA genes within each exposure paradigm. Using behavioral measures from cocaine self-administering mice, we also found several genes whose expression patterns corelate with cocaine intake. In addition to overall gene expression levels, we identified several predicted upstream regulators of cocaine-induced transcription shared across all paradigms. Although distinct gene sets were altered across cocaine exposure paradigms, we found, from Gene Ontology (GO) term analysis, that biological processes important for energy regulation and synaptic plasticity were affected across all cocaine paradigms. Coexpression analysis also identified gene networks that are altered by cocaine. These data indicate that cocaine alters networks enriched with glial cell markers of the VTA that are involved in gene regulation and synaptic processes. Our analyses demonstrate that transcriptional changes within the VTA depend on the route, dose and context of cocaine exposure, and highlight several biological processes affected by cocaine. Overall, these findings provide a unique resource of gene expression data for future studies examining novel cocaine gene targets that regulate drug-associated behaviors.

scholarly journals Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area   Opioid Receptors

2015 ◽  
Vol 35 (35) ◽  
pp. 12217-12231 ◽  
Author(s):  
L. Hipolito ◽  
A. Wilson-Poe ◽  
Y. Campos-Jurado ◽  
E. Zhong ◽  
J. Gonzalez-Romero ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Opioid Receptors ◽  
Inflammatory Pain ◽  
Self Administration ◽  
Ventral Tegmental

scholarly journals Fostering itself increases nicotine self-administration in young adult male rats

2013 ◽  
Vol 229 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Emily E. Roguski ◽  
Hao Chen ◽  
Burt M. Sharp ◽  
Shannon G. Matta
Keyword(s):  
Young Adult ◽  
Adult Male ◽  
Male Rats ◽  
Self Administration ◽  
Young Adult Male

Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

2003 ◽  
Vol 284 (5) ◽  
pp. R1260-R1268 ◽  
Author(s):  
Nicholas T. Bello ◽  
Kristi L. Sweigart ◽  
Joan M. Lakoski ◽  
Ralph Norgren ◽  
Andras Hajnal
Keyword(s):  
Ventral Tegmental Area ◽  
Drugs Of Abuse ◽  
Sucrose Solution ◽  
Male Rats ◽  
Mrna Levels ◽  
Restricted Feeding ◽  
Cellular Mechanisms ◽  
Dopamine System ◽  
Ventral Tegmental ◽  
Protein Density

Recent studies suggest that the mesoaccumbens dopamine system undergoes neurochemical alterations as a result of restricted feeding conditions with access to sugars. This effect appears to be similar to the neuroadaptation resulting from drugs of abuse and may underlay some pathological feeding behaviors. To further investigate the cellular mechanisms of these alterations, the present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (DAT) protein density and mRNA expression in restricted-fed and free-fed adult male rats. The restricted feeding regimen consisted of daily limited access to either a normally preferred sucrose solution (0.3 M) or a less preferred chow in a scheduled (i.e., contingent) fashion for 7 days. Restricted-fed rats with the contingent sucrose access lost less body weight, ate more total food, and drank more fluid than free-fed, contingent food, or noncontingent controls. In addition, these animals had selectively higher DAT binding in the nucleus accumbens and ventral tegmental area. This increase in protein binding also was accompanied by an increase in DAT mRNA levels in the ventral tegmental area. In contrast to the restricted-fed groups, no differential effect in DAT regulation was observed across free-fed groups. The observed alteration in behavior and DAT regulation suggest that neuroadaptation in the mesoaccumbens dopamine system develops in response to repeated feeding on palatable foods under dietary constraints. This supports the notion that similar cellular changes may be involved in restrictive eating disorders and bingeing.

Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors

2014 ◽  
Vol 20 (2) ◽  
pp. 302-315 ◽  
Author(s):  
Gajanan P. Shelkar ◽  
Atmaram D. Kale ◽  
Uday Singh ◽  
Praful S. Singru ◽  
Nishikant K. Subhedar ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Self Administration ◽  
Melanocyte Stimulating Hormone ◽  
Ventral Tegmental ◽  
Stimulating Hormone

Chronic cadmium exposure alters cocaine self-administration in adult male rats.

1996 ◽  
Vol 4 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Jack R. Nation ◽  
Christina L. Livermore ◽  
Gerald R. Bratton ◽  
Susan Schenk
Keyword(s):  
Adult Male ◽  
Cadmium Exposure ◽  
Male Rats ◽  
Self Administration
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