Oral thymoquinone modulates cyclophosphamide‐induced testicular toxicity in adolescent Wistar rats

Andrologia ◽  
2022 ◽  
Author(s):  
Misturah Y. Adana ◽  
Aminu Imam ◽  
Ahmed A. Bello ◽  
Olawale E. Sunmonu ◽  
Ezekiel P. Alege ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Testicular Toxicity

scholarly journals Protective Effect of Rasayana Herbs on Lead Acetate-induced Testicular Toxicity in Wistar Rats

2021 ◽  
Vol 35 (1) ◽  
pp. 9-15
Author(s):  
Vikas Sharma ◽  
Nagendra S Chauhan ◽  
Umesh K Patil ◽  
Vinod Kumar Dixit
Keyword(s):  
Protective Effect ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Testicular Toxicity

Cyperus esculentus L. (tigernut) mitigates high salt diet‐associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Justina Nwandimma Nwangwa ◽  
Augustine Lishilinimye Udefa ◽  
Ernest Atelhe Amama ◽  
Inah Onete Inah ◽  
Hamza Joseph Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
High Salt ◽  
Testicular Toxicity ◽  
Cyperus Esculentus ◽  
High Salt Diet ◽  
Salt Diet ◽  
Testicular Steroidogenesis

scholarly journals Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin

2018 ◽  
Vol 2 ◽  
pp. 239784731881279 ◽  
Author(s):  
Olusegun Kayode Afolabi ◽  
Adedoja Dorcas Wusu ◽  
Regina Ugbaja ◽  
John Olabode Fatoki
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Sperm Count ◽  
Sperm Parameters ◽  
Lipid Hydroperoxides ◽  
Testicular Toxicity ◽  
Testicular Damage ◽  
Histological Alterations ◽  
Aluminium Phosphide

The present study was designed to investigate aluminium phosphide (ALP)-induced testicular toxicity, including its effects on sperm parameters and histological alterations in Wistar rats, and the possible protective role of hesperidin (HSD). Oral administration of ALP at 1.15 mg/kg body weight (1/10 LD50) for 30 days resulted in a significant increase in testicular malondialdehyde, lipid hydroperoxides, and oxidized protein levels. These indicators of oxidative stress were accompanied by decreased activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, followed by a drastic reduction in the non-enzymatic antioxidant indices of glutathione and total antioxidant capacity when compared to control. Furthermore, ALP treatment produced a marked reduction in sperm count, motility and viability while increasing abnormal sperm morphology and adverse histopathological changes in testis. Co-administration with HSD significantly ameliorated ALP-induced testicular damage by suppressing oxidative stress indices and enhancing antioxidant status while also improving the sperm parameters and histological alterations in ALP-treated rats. The results of the present study indicated that testicular toxic effects of ALP are due to oxidative imbalance and that HSD could be a potential therapeutic agent against ALP-induced testicular damage.

scholarly journals Potentiating effect of imidacloprid on arsenic-induced testicular toxicity in Wistar rats

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Lakshay Mahajan ◽  
Pawan Kumar Verma ◽  
Rajinder Raina ◽  
Shilpa Sood
Keyword(s):  
Wistar Rats ◽  
Testicular Toxicity

scholarly journals Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats

2020 ◽  
Vol 43 (2) ◽  
pp. 174-182 ◽  
Author(s):  
Sunday Aderemi Adelakun ◽  
Victor Okoliko Ukwenya ◽  
Grace Temitope Akingbade ◽  
Olusegun Dare Omotoso ◽  
Julius Akomaye Aniah
Keyword(s):  
Aqueous Extract ◽  
Adult Male ◽  
Wistar Rats ◽  
Solanum Melongena ◽  
Mercury Chloride ◽  
Testicular Toxicity ◽  
Male Wistar Rats

scholarly journals The novel role of resveratrol in attenuating cisplatin induced testicular toxicity in rats.

2020 ◽  
Vol 27 (09) ◽  
pp. 2023-2029
Author(s):  
Kumayl Abbas Meghji ◽  
Tariq Feroz Memon ◽  
Ahsan Aslam ◽  
Naila Noor ◽  
Ali Abbas ◽  
...  
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Semen Parameters ◽  
Seminiferous Tubules ◽  
Testicular Toxicity ◽  
Group Iii ◽  
Oxidative Markers ◽  
Group I ◽  
Group Ii

Objectives: To evaluate the anti-oxidative role of Resveratrol in Cisplatin-induced testicular toxicity in Albino Wistar rats. Study Design: Quasi-experimental study. Settings: Department of Physiology and Postgraduate Laboratory of ISRA University Hyderabad. Period: Six months from March to September 2019. Material & Methods: Twenty-four male albino Wistar rats were distributed equally into; Group-I (Control), Group-II (Cisplatin), Group-III (Cisplatin + Resveratrol). Difference in mean pre and post-experimental body weight was observed while analysis of oxidative markers, semen parameters, and histomorphology was carried out in all three groups. SPSS ver. 22 was used to analyze the data. Results: The mean body weight decreased from 241.7±8.5 gm to 196.50±9.34 gm and from 237±7.4 gm to 210.0 ± 6.50gm in groups II and III respectively. Statistically significant reduction in semen parameters (sperm count, motility and viability) was observed in Group-II compared with Group-C (p<0.05). Oxidative markers were also significantly depleted in Group-II in comparison to Group-C (p<0.05). Histologically, testicular structure was found to be intact in Group-I. Marked changes were observed in testicular histology of Group-II while Group-III displayed less testicular damage. Irregular, regressive and atrophic seminiferous tubules were seen in Group-II. Most seminiferous tubules having normal morphology were observed in Group-III while the number of atrophic and degenerative seminiferous tubules also decreased significantly. Conclusion: Resveratrol therapy is a potent protective regime showing promising results in cisplatin-induced testicular toxicity and oxidative stress.

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